DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31650 and rcn2

DIOPT Version :9

Sequence 1:	NP_001162879.1	Gene:	CG31650 / 326150	FlyBaseID:	FBgn0031673	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_001025434.1	Gene:	rcn2 / 571340	ZFINID:	ZDB-GENE-050706-62	Length:	322	Species:	Danio rerio

Alignment Length:	350	Identity:	113/350 - (32%)
Similarity:	173/350 - (49%)	Gaps:	49/350 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NLPLLPLTLCAVALLAAVGPMPAHGAVANSHKHEKHLSKERVKDGIYAPRDAHHHGEDGEHNVEF 68
            |.|...|.:....||..|..:  .|||.|   .|.|:.|             |:|    |||.
Zfish    11 NPPFKSLKIRYTFLLLLVAYV--SGAVGN---REDHVFK-------------HNH----EHNA-- 51

  Fly    69 DHEAIIGNTKEAQEFDSLSPDESKRRLLILIKMMDLNKDEFIDRHELKAWILRSFKKLSEEEAAD 133
              ...:| :::..|...|||.|.::||:.::|.:|.|.|:::...|:..||.|.::|.:.::|.:
Zfish    52 --NTFLG-SEDKDEIQKLSPSEQRKRLVEIVKKIDTNSDKYLTPEEITVWIQRVYRKYALDDAEE 113

  Fly   134 RFEEIDQDADERITWKEYLQDTYAMEDEDFKKETIDYDS---YED-EQKMIK----QDKEMFNAA 190
            ||.|.|.:.|..::|.||....:.        .|::.|:   .|| |::.::    ::|..|:.|
Zfish   114 RFPEFDSNNDGLVSWDEYNMVMHG--------HTVEVDADAVLEDPEEESLRFLHAKEKRRFDFA 170

  Fly   191 DTNKDGVLTLEEFVLFQNPEEHPQMLPILLEHTMQDKDADHDGKINFQEFVGDAASHHDKE---W 252
            :.:....|.|.||:.|.:|.|...|....:|..:.:.|.|.||.|:..||:||..::...|   |
Zfish   171 NMDGSAGLNLTEFLAFTHPSEVDHMTDFAIEDVLSEYDLDKDGFISLSEFIGDLRTNEQDEPSQW 235

  Fly   253 LITEKERFDKDHDSNGDGVLTGDEVLSWIVPSNTAIANDEVDHLFVSTDEDHDDRLSYLEILNNY 317
            .|.|..||...:|.:.||.|..||.|.|:.|::...|.:|..||....|:|.|:|||..|||.|.
Zfish   236 EIEETVRFKDLYDQDQDGKLNRDEQLRWVAPNSYGSAREEALHLIKEMDQDGDNRLSETEILKNQ 300

  Fly   318 DTFVGSEATDYGDHLQNINHLSDEL 342
            |||:.||.||||..| ::.|  |||
Zfish   301 DTFMHSEVTDYGRQL-HVPH--DEL 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31650	NP_001162879.1	EF-hand_7	100..153	CDD:290234	18/52 (35%)
		EFh	100..153	CDD:298682	18/52 (35%)
		EF-hand_7	184..241	CDD:290234	18/56 (32%)
		EFh	184..241	CDD:298682	18/56 (32%)
		EFh	228..281	CDD:298682	22/55 (40%)
rcn2	NP_001025434.1	EFh	74..136	CDD:298682	20/61 (33%)
		EF-hand_7	75..131	CDD:290234	17/55 (31%)
		EF-hand_7	164..221	CDD:290234	18/56 (32%)
		EFh	165..221	CDD:298682	17/55 (31%)
		EFh	200..265	CDD:238008	24/64 (38%)
		EF-hand_7	200..259	CDD:290234	20/58 (34%)
		EF-hand_7	245..298	CDD:290234	21/52 (40%)
		EFh	245..298	CDD:298682	21/52 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580658
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4223
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2176
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46113
OrthoDB	1	1.010	-	-		D372250at33208
OrthoFinder	1	1.000	-	-		FOG0000638
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108120
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8362
SonicParanoid	1	1.000	-	-		X5175
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.650