DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31650 and calub

DIOPT Version :9

Sequence 1:	NP_001162879.1	Gene:	CG31650 / 326150	FlyBaseID:	FBgn0031673	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_957376.1	Gene:	calub / 394057	ZFINID:	ZDB-GENE-040426-1251	Length:	315	Species:	Danio rerio

Alignment Length:	301	Identity:	106/301 - (35%)
Similarity:	170/301 - (56%)	Gaps:	16/301 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 KDGIYAPRDAHHHGEDGEHNVEFDHEAIIGNTKEAQEFDSLSPDESKRRLLILIKMMDLNKDEFI 110
            ||.::......:...|.|.|.::||||.:|. :||:.||.|:|:|||.||..:::.:|.:.|.|:
Zfish    25 KDRVHHDAPLSNKDHDDEENFDYDHEAFLGQ-EEAKTFDQLTPEESKERLGKIVEKIDEDHDGFV 88

  Fly   111 DRHELKAWILRSFKKLSEEEAADRFEEIDQDADERITWKEYLQDTYA-MEDEDFKKETIDYDSYE 174
            ...|:|.||..:.::...|:...:::..|.::|..::|:||...||. :.||...::..:|
Zfish    89 TADEMKRWIKHAQRRWIYEDVDRQWQAHDLNSDSFVSWEEYKDATYGYILDEADPEDGFNY---- 149

  Fly   175 DEQKMIKQDKEMFNAADTNKDGVLTLEEFVLFQNPEEHPQMLPILLEHTMQDKDADHDGKINFQE 239
              ::|:.:|:..|..||.:.|.....|||..|.:|||...|..|::..||:|.|.:.||.|:..|
Zfish   150 --RQMMTRDERRFKMADQDGDLRANKEEFTAFLHPEEFDYMKDIVVLETMEDIDKNGDGLIDLNE 212

  Fly   240 FVGDAASHH----DKEWLITEKERFDKDHDSNGDGVLTGDEVLSWIVPSNTAIANDEVDHLFVST 300
            ::||..|.:    :.||:.||:|:|.:..|.|.||.:..||...||:|::...|..|..||...:
Zfish   213 YIGDMYSQNGDSSEPEWVKTEREQFTEFRDKNKDGRMDKDETRDWILPADYDHAEAEAKHLLYES 277

  Fly   301 DEDHDDRLSYLEILNNYDTFVGSEATDYGDHLQNINHLSDE 341
            |.|.|.||:..||::.||.||||:|||:||.|  :.|  ||
Zfish   278 DADKDGRLTKQEIVDKYDLFVGSQATDFGDAL--VRH--DE 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31650	NP_001162879.1	EF-hand_7	100..153	CDD:290234	13/52 (25%)
		EFh	100..153	CDD:298682	13/52 (25%)
		EF-hand_7	184..241	CDD:290234	21/56 (38%)
		EFh	184..241	CDD:298682	21/56 (38%)
		EFh	228..281	CDD:298682	20/56 (36%)
calub	NP_957376.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..42		3/16 (19%)
		EFh	45..98	CDD:298682	22/53 (42%)
		EF-hand_7	73..132	CDD:290234	14/58 (24%)
		EFh	75..132	CDD:298682	13/56 (23%)
		EF-hand_7	157..214	CDD:290234	21/56 (38%)
		EFh	157..214	CDD:298682	21/56 (38%)
		EFh	198..258	CDD:298682	21/59 (36%)
		Prevents secretion from ER. /evidence=ECO:0000250	312..315		3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4223
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D372250at33208
OrthoFinder	1	1.000	-	-		FOG0000638
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820