DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31650 and Rcn2

DIOPT Version :9

Sequence 1:	NP_001162879.1	Gene:	CG31650 / 326150	FlyBaseID:	FBgn0031673	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_058828.2	Gene:	Rcn2 / 29218	RGDID:	3548	Length:	320	Species:	Rattus norvegicus

Alignment Length:	339	Identity:	117/339 - (34%)
Similarity:	180/339 - (53%)	Gaps:	38/339 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VGPMPA----------HGAVANSHKHEKHLSKERVKDGIYAPRDAHHHGEDGEHNVEFDHEAIIG 75
            :||.||          :.|||.:.|.|:                  .|...|||..::|.|.::|
  Rat     3 LGPRPAVLGLLLLLLLYAAVAGASKAEE------------------LHYPQGEHRADYDRETLLG 49

  Fly    76 NTKEAQEFDSLSPDESKRRLLILIKMMDLNKDEFIDRHELKAWILRSFKKLSEEEAADRFEEIDQ 140
            ..::..|:..|..:|.:|||..:||.:|.:.|.|:..:||..||..|||..:.:||..:|.|.|:
  Rat    50 VQEDVDEYVKLGHEEQQRRLQSIIKKIDSDSDGFLTENELSQWIQMSFKHYAMQEAKQQFVEYDK 114

  Fly   141 DADERITWKEYLQDTYAMEDE--DFKKETIDYDSYEDEQKMIK-QDKEMFNAADTNKDGVLTLEE 202
            ::|..:||.||   ...|.|.  ||.:.|...|:.|:..:.:. :||:.|..|:.:....|.|||
  Rat   115 NSDGTVTWDEY---NVQMYDRVIDFDENTALDDTEEESFRQLHLKDKKRFEKANQDSGPGLNLEE 176

  Fly   203 FVLFQNPEEHPQMLPILLEHTMQDKDADHDGKINFQEFVG----DAASHHDKEWLITEKERFDKD 263
            |:.|::|||...|...:::..:::.|.:.||.::.:||:|    |..::.|.||::.||:||..|
  Rat   177 FIAFEHPEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGDYRRDPTANEDPEWILVEKDRFVND 241

  Fly   264 HDSNGDGVLTGDEVLSWIVPSNTAIANDEVDHLFVSTDEDHDDRLSYLEILNNYDTFVGSEATDY 328
            :|.:.||.|...|:|||:||:|..||.:|..||....|.:.|.:||..|||.|.|.|:.||||||
  Rat   242 YDKDSDGRLDPQELLSWVVPNNQGIAQEEALHLIDEMDLNSDKKLSEEEILENQDLFLTSEATDY 306

  Fly   329 GDHLQNINHLSDEL 342
            |..|.:.....|||
  Rat   307 GRQLHDDYFYHDEL 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31650	NP_001162879.1	EF-hand_7	100..153	CDD:290234	21/52 (40%)
		EFh	100..153	CDD:298682	21/52 (40%)
		EF-hand_7	184..241	CDD:290234	17/56 (30%)
		EFh	184..241	CDD:298682	17/56 (30%)
		EFh	228..281	CDD:298682	22/56 (39%)
Rcn2	NP_058828.2	EFh	68..124	CDD:238008	22/55 (40%)
		EF-hand_7	69..125	CDD:290234	21/55 (38%)
		EF-hand_7	194..259	CDD:290234	22/64 (34%)
		EFh	194..259	CDD:298682	22/64 (34%)
		EFh	240..293	CDD:298682	23/52 (44%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	317..320		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340815
Domainoid	1	1.000	59	1.000	Domainoid score	I10451
eggNOG	1	0.900	-	-		E1_KOG4223
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2176
Inparanoid	1	1.050	202	1.000	Inparanoid score	I3686
OMA	1	1.010	-	-		QHG46113
OrthoDB	1	1.010	-	-		D372250at33208
OrthoFinder	1	1.000	-	-		FOG0000638
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108120
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5175
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.670