DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31650 and calu-2

DIOPT Version :9

Sequence 1:	NP_001162879.1	Gene:	CG31650 / 326150	FlyBaseID:	FBgn0031673	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_491936.3	Gene:	calu-2 / 184174	WormBaseID:	WBGene00017240	Length:	286	Species:	Caenorhabditis elegans

Alignment Length:	301	Identity:	102/301 - (33%)
Similarity:	158/301 - (52%)	Gaps:	33/301 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 KERVKDGIYAPRDAHHHGEDGEHNVEFDHEAIIGNTKEAQEFDSLSPDESKRRLLILIKMMDLNK 106
            |||:.||..:|.|......:.:.|::...|::       ::|               .|.:|.|.
Worm    19 KERMMDGSVSPSDHKKPASEQKLNLKSGQESV-------EKF---------------AKALDTNN 61

  Fly   107 DEFIDRHELKAWILRSFKKLSEEEAADRFEEIDQDADERITWKEYLQDTYAMEDEDFKKETIDYD 171
            |.|:|:.|:.||:..|::|..:.||.:|..|:|::||..::|:|||.|::  .||:...
Worm    62 DGFVDKSEILAWVSESYQKTVDREAVERISELDENADGFVSWEEYLADSF--PDEELHN------ 118

  Fly   172 SYEDEQKMIKQDKEMFNAADTNKDGVLTLEEFVLFQNPEEHPQMLPILLEHTMQDKDADHDGKIN 236
              ::|:.:|.|||..|..||.:.||.|.|||...|.|||.||.|.|:|:..|:.:||.:.||.|.
Worm   119 --KEEESLIAQDKMYFKQADEDNDGKLNLEELASFLNPEHHPHMHPVLIAVTLLEKDQNGDGAIE 181

  Fly   237 FQEFVGDAASHHDKEWLITEKERFDKDHDSNGDGVLTGDEVLSWIVPSNTAIANDEVDHLFVSTD 301
            .:||:|:.......||...|.|||...:|.|.||.|.|||:..|::...|...:.|.:.|..::|
Worm   182 EKEFLGELDEQRGSEWYKVEVERFRTVYDKNKDGKLAGDELTDWLLVDGTTAGSYEAESLLTNSD 246

  Fly   302 EDHDDRLSYLEILNNYDTFVGSEATDYGDHLQNINHLSDEL 342
            :|.|.:|||.||:.::..|..:||....|||... :..|||
Worm   247 DDKDGQLSYEEIVKHHALFAKTEAAQEADHLHPY-YSHDEL 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31650	NP_001162879.1	EF-hand_7	100..153	CDD:290234	21/52 (40%)
		EFh	100..153	CDD:298682	21/52 (40%)
		EF-hand_7	184..241	CDD:290234	26/56 (46%)
		EFh	184..241	CDD:298682	26/56 (46%)
		EFh	228..281	CDD:298682	21/52 (40%)
calu-2	NP_491936.3	PTZ00183	33..186	CDD:185503	58/184 (32%)
		EFh	55..108	CDD:298682	21/52 (40%)
		EFh	85..152	CDD:298682	28/76 (37%)
		PTZ00184	122..260	CDD:185504	57/137 (42%)
		EFh	203..263	CDD:298682	23/59 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159325
Domainoid	1	1.000	52	1.000	Domainoid score	I7720
eggNOG	1	0.900	-	-		E1_KOG4223
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	183	1.000	Inparanoid score	I2634
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46113
OrthoDB	1	1.010	-	-		D372250at33208
OrthoFinder	1	1.000	-	-		FOG0000638
OrthoInspector	1	1.000	-	-		oto18499
orthoMCL	1	0.900	-	-		OOG6_108120
Panther	1	1.100	-	-	LDO	PTHR10827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8362
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.800