DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CDC50 and Tmem30b

DIOPT Version :9

Sequence 1:	NP_573128.2	Gene:	CDC50 / 32615	FlyBaseID:	FBgn0030752	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_001073849.1	Gene:	Tmem30b / 314224	RGDID:	1308732	Length:	353	Species:	Rattus norvegicus

Alignment Length:	342	Identity:	167/342 - (48%)
Similarity:	226/342 - (66%)	Gaps:	17/342 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SAAAK-SKRPSDSAFKQQRLPAWQPVLTARTVLPTFFVIGVLFIPIGVVLLHLSNTANELIIDYT 74
            ||:|: :::|.::||.|||||||||:|:|...||.||..|:.||.:|:.|.:.||...||..|||
  Rat     4 SASARGAQQPDNTAFTQQRLPAWQPLLSAGITLPLFFCAGLAFIGLGLGLFYSSNGIQELEYDYT 68

  Fly    75 KCRRSGGNTTC-AEYLEANPGVTCPCEVPFVLPSDFNGVVYMYYGLTNYYQNHRRYVKSRDDEQL 138
            ....:|..:.| |:..:..|..:|.|...|.||..|.|.||:||.|:|:|||:|||..||||.||
  Rat    69 GNPGTGNCSVCAAKGQDRAPPPSCQCSWSFTLPELFPGPVYLYYELSNFYQNNRRYGVSRDDAQL 133

  Fly   139 LGHLS--QTPSTDCAPFAYDPDSGKPIAPCGAIANSLFNDTLTLLQGGS------EIKLLKTGIA 195
            .|..|  :.|:.:|||:.:..| |.|||||||||||||||:.:|.....      |:.|.:|.||
  Rat   134 SGLASALRHPANECAPYQFSSD-GLPIAPCGAIANSLFNDSFSLWHQRQPADPFVEVPLDRTAIA 197

  Fly   196 WPSDKRVKFRNP---EGNLNVSLEGFSKPIFWQKGLADLDPENPDNNGFQNEDLIVWMRTAALPS 257
            |.:|..||||||   .|:|.::.:|.:.|..|.:.:.:|.|: |:|.||.|:|.:|||||||||:
  Rat   198 WWTDYHVKFRNPPLVNGSLALAFKGTAPPPNWHRPVYELSPD-PNNTGFINQDFVVWMRTAALPT 261

  Fly   258 FRKLYRRLNQTNTNYANGLKSGNYTLNIKYNYPVVSFDGTKRMILSTTSVLGGKNPFLGIAYIVV 322
            |||||.|:.|  .||:.||..|.|.:||.|||||.:|.|.|.:|||..|.:|||||||||||:||
  Rat   262 FRKLYARIRQ--GNYSAGLPRGTYRVNITYNYPVRAFGGHKLIILSNISWMGGKNPFLGIAYLVV 324

  Fly   323 GAICITLGLALLFIHMR 339
            |::||.:|..:|.:::|
  Rat   325 GSLCILMGFVMLVVYIR 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDC50	NP_573128.2	CDC50	67..340	CDD:281387	139/285 (49%)
Tmem30b	NP_001073849.1	CDC50	60..342	CDD:281387	139/286 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341858
Domainoid	1	1.000	257	1.000	Domainoid score	I1949
eggNOG	1	0.900	-	-		E1_COG5035
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53602
OrthoDB	1	1.010	-	-		D461644at33208
OrthoFinder	1	1.000	-	-		FOG0000577
OrthoInspector	1	1.000	-	-		oto98613
orthoMCL	1	0.900	-	-		OOG6_100927
Panther	1	1.100	-	-	O	PTHR10926
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X371
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.720