DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CDC50 and TMEM30B

DIOPT Version :9

Sequence 1:	NP_573128.2	Gene:	CDC50 / 32615	FlyBaseID:	FBgn0030752	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_001017970.1	Gene:	TMEM30B / 161291	HGNCID:	27254	Length:	351	Species:	Homo sapiens

Alignment Length:	345	Identity:	169/345 - (48%)
Similarity:	223/345 - (64%)	Gaps:	23/345 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SAAAK-SKRPSDSAFKQQRLPAWQPVLTARTVLPTFFVIGVLFIPIGVVLLHLSNTANELIIDYT 74
            ||.|: :.:|.::||.|||||||||:|:|...||.||..|:.||.:|:.|.:.||...||..|||
Human     4 SATARGAHQPDNTAFTQQRLPAWQPLLSASIALPLFFCAGLAFIGLGLGLYYSSNGIKELEYDYT 68

  Fly    75 KCRRSGGNTTCAEYLEANPG----VTCPCEVPFVLPSDFNGVVYMYYGLTNYYQNHRRYVKSRDD 135
            ....:|..:.||   .|..|    ..|.|...|.||..|.|.||:||.|||:|||:|||..||||
Human    69 GDPGTGNCSVCA---AAGQGRALPPPCSCAWYFSLPELFQGPVYLYYELTNFYQNNRRYGVSRDD 130

  Fly   136 EQLLGHLS--QTPSTDCAPFAYDPDSGKPIAPCGAIANSLFNDTLTLLQ----GGS--EIKLLKT 192
            .||.|..|  :.|..:|||:.... :|.|||||||||||||||:.:|..    ||.  |:.|.::
Human   131 AQLSGLPSALRHPVNECAPYQRSA-AGLPIAPCGAIANSLFNDSFSLWHQRQPGGPYVEVPLDRS 194

  Fly   193 GIAWPSDKRVKFRNP---EGNLNVSLEGFSKPIFWQKGLADLDPENPDNNGFQNEDLIVWMRTAA 254
            ||||.:|..||||||   .|:|.::.:|.:.|..|::.:.:|.|: |:|.||.|:|.:|||||||
Human   195 GIAWWTDYHVKFRNPPLVNGSLALAFQGTAPPPNWRRPVYELSPD-PNNTGFINQDFVVWMRTAA 258

  Fly   255 LPSFRKLYRRLNQTNTNYANGLKSGNYTLNIKYNYPVVSFDGTKRMILSTTSVLGGKNPFLGIAY 319
            ||:|||||.|:.|  .||:.||..|.|.:||.|||||.:|.|.|.:|.|:.|.:|||||||||||
Human   259 LPTFRKLYARIRQ--GNYSAGLPRGAYRVNITYNYPVRAFGGHKLLIFSSISWMGGKNPFLGIAY 321

  Fly   320 IVVGAICITLGLALLFIHMR 339
            :|||::||..|..:|.:::|
Human   322 LVVGSLCILTGFVMLVVYIR 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDC50	NP_573128.2	CDC50	67..340	CDD:281387	141/288 (49%)
TMEM30B	NP_001017970.1	CDC50	55..340	CDD:397450	142/291 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147989
Domainoid	1	1.000	277	1.000	Domainoid score	I1736
eggNOG	1	0.900	-	-		E1_COG5035
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53602
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000577
OrthoInspector	1	1.000	-	-		otm42164
orthoMCL	1	0.900	-	-		OOG6_100927
Panther	1	1.100	-	-	O	PTHR10926
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X371
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.710