Protein Alignment CG31445 and NPEPPS

DIOPT Version :10

• Sequence 1: NP_651689.1
• Gene: CG31445 / 326140
• FlyBaseID: FBgn0051445
• Length: 927
• Species: Drosophila melanogaster
• Sequence 2: NP_001398059.1
• Gene: NPEPPS / 9520
• HGNCID: 7900
• Length: 924
• Species: Homo sapiens
• Alignment Length: 869
• Identity: 262/869 - (30%)
• Similarity: 426/869 - (49%)
• Gaps: 90/869 - (10%)

  Fly    28 RLPTALRPQRYYLRILTLLESPD--DLRFAGNVQIVIKALQNTRNITLHSKNLTIDESRITLRQI 90
            |||..:.|..|     :|...||  |..|.|.::...:..|.|..|.::..::.|    ||   .
Human    53 RLPADVSPINY-----SLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDI----IT---A 105

  Fly    91 SGAGNMDNCVSSTSVN-PTHDYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYKDPVTN 154
            |.|...|..:.:|..| ...|..:..:....|......|.:.|..:|..::.|:|||.|..| :.
Human   106 SYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTP-SG 169

  Fly   155 KTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLANYIWCE 219
            :.|:.:.||||.:.||:||||:|||..||:|.::|...|...|||||.|.:.:|:....|.:..:
Human   170 EVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVK 234

  Fly   220 FQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAIDQCDYAAEFGPKVLQYYEEFFGIR 284
            |..:..|||||||:.|.::.|..:...:|...|.:......:|..:|.|...|.|.:|:::|.:.
Human   235 FARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVP 299

  Fly   285 YPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVT 349
            |||||||.:|:.||:||||||||||.|||:.||..|.:|..:.:|.:|.|:.|||||||||||||
Human   300 YPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVT 364

  Fly   350 MKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHPISRPIQMVTEI 414
            |:|||.||||||||:::..|.|...:||:....:........|..||:|.:||||...:...:|:
Human   365 MEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEV 429

  Fly   415 EESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQNGALPG 479
            :|.||||||.||::|:||:|.::|::.|:.|:..||..:..|||...:|||||..|:.:
Human   430 DEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENASGK------ 488

  Fly   480 HYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRNSQ-------------IPQADRVGC 531
              .|..:|::||.|.|||::.:..:      ::..:|.||.||             .||
Human   489 --PIAAVMNTWTKQMGFPLIYVEAE------QVEDDRLLRLSQKKFCAGGSYVGEDCPQ------ 539

  Fly   532 WWVPLSYTTQDENDFNNTSPKAWMECSSTDEGVPTTIDHSAGPEEWLILNIQLSTPYKANYDARN 596
            |.||::.:|.:  |.|....|..|     |:.....:..:..|::|:.||:.....|:..|.:..
Human   540 WMVPITISTSE--DPNQAKLKILM-----DKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAM 597

  Fly   597 WKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDNL 661
            .:.|:..:  :|. |:..::|..|.:|:...|..|.......|:|......|.:...|.....||
Human   598 LESLLPGI--RDL-SLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNL 659

  Fly   662 KLLNRILRQTPNFGSFKRYMQKLLTPIYEHL-------HGMNDTFSLMTQQDEVLLKTTVVNVAC 719
            .:|:.:|..|..:...:.:::.:.:||.|.|       .|..|          .||:..|:....
Human   660 GILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLD----------ALLRGLVLGKLG 714

  Fly   720 QYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNVAS 784
            :......:.:|     |.|.:.:.:....:..:|||.||.|.:..|.....:.:...::::::..
Human   715 KAGHKATLEEA-----RRRFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQE 774

  Fly   785 ERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVA-SREVGFLLAKQYFIENVEL 848
            |:..|...||.:....::|:.:  :|.....:|.||:......|| ..:.|...|.::..:|.|.
Human   775 EKNRIERVLGATLLPDLIQKVL--TFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEE 837

  Fly   849 IHKYYYPQTRVMSRL-----LTPL 867
            ::..|.... ::|||     |||:
Human   838 LYNRYQGGF-LISRLIKVQWLTPV 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_651689.1	M1_APN-Q_like	37..492	CDD:341064	173/457 (38%)
		ERAP1_C	577..905	CDD:463368	63/304 (21%)
NPEPPS	NP_001398059.1	M1_APN-Q_like	61..499	CDD:341064	173/458 (38%)
		ERAP1_C	578..854	CDD:463368	60/296 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	726..730		2/3 (67%)