DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31445 and NPEPPS

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_016880861.1	Gene:	NPEPPS / 9520	HGNCID:	7900	Length:	924	Species:	Homo sapiens

Alignment Length:	869	Identity:	262/869 - (30%)
Similarity:	426/869 - (49%)	Gaps:	90/869 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RLPTALRPQRYYLRILTLLESPD--DLRFAGNVQIVIKALQNTRNITLHSKNLTIDESRITLRQI 90
            |||..:.|..|     :|...||  |..|.|.::...:..|.|..|.::..::.|    ||   .
Human    53 RLPADVSPINY-----SLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDI----IT---A 105

  Fly    91 SGAGNMDNCVSSTSVN-PTHDYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYKDPVTN 154
            |.|...|..:.:|..| ...|..:..:....|......|.:.|..:|..::.|:|||.|..| :.
Human   106 SYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTP-SG 169

  Fly   155 KTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLANYIWCE 219
            :.|:.:.||||.:.||:||||:|||..||:|.::|...|...|||||.|.:.:|:....|.:..:
Human   170 EVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVK 234

  Fly   220 FQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAIDQCDYAAEFGPKVLQYYEEFFGIR 284
            |..:..|||||||:.|.::.|..:...:|...|.:......:|..:|.|...|.|.:|:::|.:.
Human   235 FARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVP 299

  Fly   285 YPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVT 349
            |||||||.:|:.||:||||||||||.|||:.||..|.:|..:.:|.:|.|:.|||||||||||||
Human   300 YPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVT 364

  Fly   350 MKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHPISRPIQMVTEI 414
            |:|||.||||||||:::..|.|...:||:....:........|..||:|.:||||...:...:|:
Human   365 MEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEV 429

  Fly   415 EESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQNGALPG 479
            :|.||||||.||::|:||:|.::|::.|:.|:..||..:..|||...:|||||..|:.:
Human   430 DEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENASGK------ 488

  Fly   480 HYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRNSQ-------------IPQADRVGC 531
              .|..:|::||.|.|||::.:..:      ::..:|.||.||             .||
Human   489 --PIAAVMNTWTKQMGFPLIYVEAE------QVEDDRLLRLSQKKFCAGGSYVGEDCPQ------ 539

  Fly   532 WWVPLSYTTQDENDFNNTSPKAWMECSSTDEGVPTTIDHSAGPEEWLILNIQLSTPYKANYDARN 596
            |.||::.:|.:  |.|....|..|     |:.....:..:..|::|:.||:.....|:..|.:..
Human   540 WMVPITISTSE--DPNQAKLKILM-----DKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAM 597

  Fly   597 WKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDNL 661
            .:.|:..:  :|. |:..::|..|.:|:...|..|.......|:|......|.:...|.....||
Human   598 LESLLPGI--RDL-SLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNL 659

  Fly   662 KLLNRILRQTPNFGSFKRYMQKLLTPIYEHL-------HGMNDTFSLMTQQDEVLLKTTVVNVAC 719
            .:|:.:|..|..:...:.:::.:.:||.|.|       .|..|          .||:..|:....
Human   660 GILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLD----------ALLRGLVLGKLG 714

  Fly   720 QYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNVAS 784
            :......:.:|     |.|.:.:.:....:..:|||.||.|.:..|.....:.:...::::::..
Human   715 KAGHKATLEEA-----RRRFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQE 774

  Fly   785 ERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVA-SREVGFLLAKQYFIENVEL 848
            |:..|...||.:....::|:.:  :|.....:|.||:......|| ..:.|...|.::..:|.|.
Human   775 EKNRIERVLGATLLPDLIQKVL--TFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEE 837

  Fly   849 IHKYYYPQTRVMSRL-----LTPL 867
            ::..|.... ::|||     |||:
Human   838 LYNRYQGGF-LISRLIKVQWLTPV 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	154/400 (39%)
		M1_APN_2	43..497	CDD:189008	175/456 (38%)
		ERAP1_C	578..904	CDD:288671	62/303 (20%)
NPEPPS	XP_016880861.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820