Protein Alignment CG31445 and AAP1

DIOPT Version :10

• Sequence 1: NP_651689.1
• Gene: CG31445 / 326140
• FlyBaseID: FBgn0051445
• Length: 927
• Species: Drosophila melanogaster
• Sequence 2: NP_011913.1
• Gene: AAP1 / 856443
• SGDID: S000001089
• Length: 856
• Species: Saccharomyces cerevisiae
• Alignment Length: 907
• Identity: 273/907 - (30%)
• Similarity: 431/907 - (47%)
• Gaps: 69/907 - (7%)

  Fly    29 LPTALRPQRYYLRILTLLESPDDLRFAGNVQIVIKALQNTRN-ITLHSKNLTIDESRITLRQISG 92
            ||..:.|..|   .:||..:.....|.|:::|.::...::.| :.::...:....:||.......
Yeast     6 LPNNVTPLHY---DITLEPNFRAFTFEGSLKIDLQINDHSINSVQINYLEIDFHSARIEGVNAIE 67

  Fly    93 AGNMDNCVSSTSVNPTHDYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYKDPVTNKTR 157
            ....:|...:|.|.|...:       |.| |...||.:.||..|..|:.|:||:.|.|.||.:|:
Yeast    68 VNKNENQQKATLVFPNGTF-------ENL-GPSAKLEIIFSGILNDQMAGFYRAKYTDKVTGETK 124

  Fly   158 WLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLANYIWCEFQE 222
            :::.||.|.:.||:||||||||..||:|.|||........||||.||.....|...   :..|..
Yeast   125 YMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDVRNETIKEGKK---YTTFNT 186

  Fly   223 SVPMSTYLVAYSVNDFSFKPST---LPNGALFRTWARPNAIDQCDYAAEFGPKVLQYYEEFFGIR 284
            :..|||||||:.|.|..:..|.   :|    .|.::.|.......:||....:.|:::|:.|.|.
Yeast   187 TPKMSTYLVAFIVADLRYVESNNFRIP----VRVYSTPGDEKFGQFAANLAARTLRFFEDTFNIE 247

  Fly   285 YPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVT 349
            |||||:|.:||.:||||||||||||.||...||....:|||...|.:|.||.|||||||||||||
Yeast   248 YPLPKMDMVAVHEFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAEVIQHELAHQWFGNLVT 312

  Fly   350 MKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHPISRPIQMVTEI 414
            |.||..|||||||||:::.....:..|||...::.....|..|..||||.|||||..|:....||
Yeast   313 MDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLRSSHPIEVPVNNADEI 377

  Fly   415 EESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQNGALPG 479
            .:.||||||.|||::|||:..::|||:|..|:.:||..:.|.||:..:||::|..|:.:
Yeast   378 NQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWDALADASGK------ 436

  Fly   480 HYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRNSQIPQADRVGCWWVPLSYTTQDEN 544
              |:.::|:.||.:.|||||::....:..|  :||.|||....:.:.:....:  |:....:|..
Yeast   437 --DVCSVMNIWTKRVGFPVLSVKEHKNKIT--LTQHRYLSTGDVKEEEDTTIY--PILLALKDST 495

  Fly   545 DFNNTSPKAWMECSSTDEGVPTTIDHSAGPEEWLILNIQLSTPYKANYDARNWKLLIDTLNSKDF 609
            ..:||  ....|.|:|.|         ...||:..:|...|..:..:|....|..|     ||..
Yeast   496 GIDNT--LVLNEKSATFE---------LKNEEFFKINGDQSGIFITSYSDERWAKL-----SKQA 544

  Fly   610 QSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDNLKLLNR--ILRQTP 672
            ..:.|.:|..|:.|....:.:|.......|.:.:..:.|...:.|:..:::|..|..  :.....
Yeast   545 NLLSVEDRVGLVADAKALSASGYTSTTNFLNLISNWKNEDSFVVWEQIINSLSALKSTWVFEPED 609

  Fly   673 NFGSFKRYMQKLLTPIYEHLH---GMNDTFSLMTQQDEVLLKTTVVNVACQYDVSDCVTQAQAYF 734
            ...:..::...|:......|.   |.:|:|::..      ||.|:.:.||........:.|...|
Yeast   610 ILNALDKFTLDLVLNKLSELGWNIGEDDSFAIQR------LKVTLFSAACTSGNEKMQSIAVEMF 668

  Fly   735 RRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNVASERQTILSTLGCSKEV 799
            ..: |..|   ...:|...::.|:.|....|.|.::..:::.|:....:.|:...|..||..::.
Yeast   669 EEY-ANGN---KQAIPALFKAVVFNTVARLGGENNYEKIFNIYQNPVSSEEKIIALRALGRFEDK 729

  Fly   800 WILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIENVELIHKYYYPQTRVMSRLL 864
            .:|:|.:  |:.....:..||..:..|.:...:.|......:..|:.:.|.|...|.:.|:..:|
Yeast   730 ELLERTL--SYLLDGTVLNQDFYIPMQGIRVHKKGIERLWAWMQEHWDEIAKRLQPGSPVLGGVL 792

  Fly   865 TPLSEQVSTINDLNKFRSFANDSRHFLKGIRQAMQQSLETMLTNVQWMDWNYHKFSRTIRHH 926
            |......::...|.|..:|.  ||...||..|.:.|:|:|:.:..||:..:....:..:|.|
Yeast   793 TLGLTNFTSFEALEKISAFY--SRKVTKGFDQTLAQALDTIRSKAQWVSRDREIVATYLREH 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_651689.1	M1_APN-Q_like	37..492	CDD:341064	178/458 (39%)
		ERAP1_C	577..905	CDD:463368	65/332 (20%)
AAP1	NP_011913.1	M1_APN-Q_like	13..447	CDD:341064	178/459 (39%)
		ERAP1_C	517..833	CDD:463368	66/334 (20%)