DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31445 and LAP2

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_014353.1	Gene:	LAP2 / 855682	SGDID:	S000004990	Length:	671	Species:	Saccharomyces cerevisiae

Alignment Length:	771	Identity:	158/771 - (20%)
Similarity:	280/771 - (36%)	Gaps:	237/771 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFVLAIGLDLSVANSISRYNHYRLPTAL---RPQRYYLRILTLLESPD---------------- 50
            ||.|::..:.:|..       |..||.::   ||.|          ||:
Yeast    24 LLTVISRNIHISTP-------HKMLPLSIEQRRPSR----------SPEYDQSTLSNYKDFAVLH 71

  Fly    51 -DLR---------FAGNVQIVIKALQNTRNITLHSKNLTIDESRITLRQISGAGNMDNCVSSTSV 105
             ||.         .:|:|...:|.|...:|   .|..|.:|.|.:.::::...|:..:.......
Yeast    72 TDLNLSVSFEKSAISGSVTFQLKKLHEGKN---KSDELHLDTSYLDVQEVHIDGSKADFQIEQRK 133

  Fly   106 NPTHDYYIFH--TCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYKDPVTNKTRWLSA------- 161
            .|.....:.:  :|.:....|:                 .:|::.|   ....:||::
Yeast   134 EPLGSRLVINNASCNDNFTLNI-----------------QFRTTDK---CTALQWLNSKQTKGGK 178

  Fly   162 ----TQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPV--REIRPHESLANYIWCEF 220
                :|.|...||..|||||.|..|::|..::.        |.:||  ..||..::..:.....|
Yeast   179 PYVFSQLEAIHARSLFPCFDTPSVKSTFTASIE--------SPLPVVFSGIRIEDTSKDTNIYRF 235

  Fly   221 QESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAIDQCDYAAE--------FGPKVLQYY 277
            ::.||:..||:..:..|.    |:.|.|.....:..|..:..|.:..|        ...|::..|
Yeast   236 EQKVPIPAYLIGIASGDL----SSAPIGPRSTVYTEPFRLKDCQWEFENDVEKFIQTAEKIIFEY 296

  Fly   278 EEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQ 342
            |  :|....|..:|     .:..|.||:..:. :...||:   .|    |:.:: :||||||||.
Yeast   297 E--WGTYDILVNVD-----SYPYGGMESPNMT-FATPTLI---AH----DRSNI-DVIAHELAHS 345

  Fly   343 WFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPE----------WHSRDKGSLTALMTAFRLDS 397
            |.|||||...|...|||||:..|:....:..|:.|          | |..:.|:.::....|..:
Yeast   346 WSGNLVTNCSWNHFWLNEGWTVYLERRIIGAIHGEPTRHFSALIGW-SDLQNSIDSMKDPERFST 409

  Fly   398 LVSSHPISRPIQMVTEIEESFDAISYQKGSAVLRMMHLFM-GEESFRTGLREYLKLYAYKNAEQN 461
            ||.:      :...|:.:::|..:.|:||..:|..:...: |:..|...:|.|.|.:|.|:.:..
Yeast   410 LVQN------LNDNTDPDDAFSTVPYEKGFNLLFHLETILGGKAEFDPFIRHYFKKFAKKSLDTF 468

  Fly   462 NLWESLTTAAHQNGALPGHYDI----NTIMDS-----WTLQTGFPVLNITRDYSTGTAEITQERY 517
            ...::|             |:.    ..|:||     |..:.|.|.   ...:.|..|:...:
Yeast   469 QFLDTL-------------YEFYPEKKEILDSVDWETWLYKPGMPP---RPHFITALADNVYQ-- 515

  Fly   518 LRNSQIPQADRVGCWWVPLSYTTQDENDFNNTSPKAWMECSSTDEGVPTTIDHSAGPEEWLILNI 582
                   .||:    ||.::...:...||.:                           |:..::|
Yeast   516 -------LADK----WVEMAQHLKTTEDFRS---------------------------EFNAIDI 542

  Fly   583 QLSTPYKANYDARNWKLLIDTL------NSK----DFQSIHVINRAQLIDDVLYFAWTGEQDYET 637
            :       ::::....|.::||      |.|    |:....|.:||.|  |:........|:.|.
Yeast   543 K-------DFNSNQLVLFLETLTQNGHSNKKPKDFDWAKFPVASRALL--DIYQDNIVKSQNAEV 598

  Fly   638 ALQVTNY-----LRRE-RDLIPWKSALDNLK-------LLNRILRQ--TPNFGSFK 678
            ..::..:     |:.| :.|..|...:..:|       |||.:.|:  ...|..||
Yeast   599 VFKMFKFQIFAKLQEEYKHLADWLGTVGRMKFVRPGYRLLNSVDRRLALATFDKFK 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	100/459 (22%)
		M1_APN_2	43..497	CDD:189008	112/522 (21%)
		ERAP1_C	578..904	CDD:288671	26/126 (21%)
LAP2	NP_014353.1	leuko_A4_hydro	57..669	CDD:274120	146/721 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810