Protein Alignment CG31445 and APE2

DIOPT Version :10

• Sequence 1: NP_651689.1
• Gene: CG31445 / 326140
• FlyBaseID: FBgn0051445
• Length: 927
• Species: Drosophila melanogaster
• Sequence 2: NP_012765.3
• Gene: APE2 / 853699
• SGDID: S000001640
• Length: 952
• Species: Saccharomyces cerevisiae
• Alignment Length: 917
• Identity: 278/917 - (30%)
• Similarity: 451/917 - (49%)
• Gaps: 106/917 - (11%)

  Fly    25 NHYRLPTALRPQRYYLRILTLLESPD--DLRFAGNVQIVIKALQNTR--NITLHSKNLTIDESRI 85
            |...||..:.|..|.|.:     .||  ..:|.|:|:|.:| :.|..  .:||::.:..|..::|
Yeast    98 NREILPDNVVPLHYDLTV-----EPDFKTFKFEGSVKIELK-INNPAIDTVTLNTVDTDIHSAKI 156

  Fly    86 TLRQISGAGNMDNCVSSTSVNPTHDYYI--FHTCKELLA---GNVYKLFLPFSADLTPQLFGYYR 145
                    |:    |:|:.:....:..:  |...|..::   ||.: |.:.|:..|...:.|:||
Yeast   157 --------GD----VTSSEIISEEEQQVTTFAFPKGTMSSFKGNAF-LDIKFTGILNDNMAGFYR 208

  Fly   146 SSYKDPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVRE--IRP 208
            :.|:|.:|.:|::::.||.||:.||:||||||||..||||.:||........||||.|:.  ::.
Yeast   209 AKYEDKLTGETKYMATTQMEPTDARRAFPCFDEPNLKASFAITLVSDPSLTHLSNMDVKNEYVKD 273

  Fly   209 HESLANYIWCEFQESVPMSTYLVAYSVNDFSF---KPSTLPNGALFRTWARPNAIDQCDYAAEFG 270
            .:.:.     .|..:..|||||||:.|.:..:   |...:|    .|.:|.|.......:||:..
Yeast   274 GKKVT-----LFNTTPKMSTYLVAFIVAELKYVESKNFRIP----VRVYATPGNEKHGQFAADLT 329

  Fly   271 PKVLQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVI 335
            .|.|.::|:.|||:|||||:|.:||.:||||||||||||.||...||....:|:|...|.:|.|:
Yeast   330 AKTLAFFEKTFGIQYPLPKMDNVAVHEFSAGAMENWGLVTYRVVDLLLDKDNSTLDRIQRVAEVV 394

  Fly   336 AHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVS 400
            .||||||||||||||.||..|||||||||:::.....|..|||...::.....|..|..||||.|
Yeast   395 QHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNEFQPEWKVWEQYVTDTLQHALSLDSLRS 459

  Fly   401 SHPISRPIQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWE 465
            ||||..|::...||.:.||||||.||:::|||:..::|||:|..|:.:||..:.|.||:..:||:
Yeast   460 SHPIEVPVKKADEINQIFDAISYSKGASLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTEDLWD 524

  Fly   466 SLTTAAHQNGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEIT--QERYLRNSQI-PQAD 527
            :|..|:.:        |:.::|:.||.:.||||::::.|   |..:||  |.|||..:.: |..|
Yeast   525 ALADASGK--------DVRSVMNIWTKKVGFPVISVSED---GNGKITFRQNRYLSTADVKPDED 578

  Fly   528 RVGCWWVPLSYTTQDENDFNNTSPKAWMECSSTDEGVPTTIDHSAGPEEWLILNIQLSTPYKANY 592
            :. .:.|.|:..|::..|    |.....|.|.|.|....|         :..:|.:.|..|..:|
Yeast   579 KT-IYPVFLALKTKNGVD----SSVVLSERSKTIELEDPT---------FFKVNSEQSGIYITSY 629

  Fly   593 DARNWKLL---IDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPW 654
            ....|..|   .|.|:.:|        |..|:.||...:.:|.......|.:.:....|:..:.|
Yeast   630 TDERWAKLGQQADLLSVED--------RVGLVADVKTLSASGYTSTTNFLNLVSKWNNEKSFVVW 686

  Fly   655 KSALDNLKLLNR--ILRQTPNFGSFKRYMQKLLTPIYEHL---HGMNDTFSLMTQQDEVLLKTTV 714
            ...::::..:..  :........:...:.::|::.:..||   ...:|:||  ||:    ||.|:
Yeast   687 DQIINSISSMKSTWLFEPKETQDALDNFTKQLISGMTHHLGWEFKSSDSFS--TQR----LKVTM 745

  Fly   715 VNVACQYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRK 779
            ...||....:|....|...|..:.:    .....:|..::..|:.|....|..|::..::..|..
Yeast   746 FGAACAARDADVEKAALKMFTDYCS----GNKEAIPALIKPIVFNTVARVGGAENYEKVYKIYLD 806

  Fly   780 SNVASERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIE 844
            .....|:...|.:||..||..:|:|.:...|  ...:..||..:..|.:.:.:.|......:..:
Yeast   807 PISNDEKLAALRSLGRFKEPKLLERTLGYLF--DGTVLNQDIYIPMQGMRAHQEGVEALWNWVKK 869

  Fly   845 NVELIHKYYYPQTRVMSRLLTPLSE---QVSTINDLNKFRSFANDSRHFLKGIRQAMQQSLETML 906
            |.:.:.|...|...::..::|..:.   .:..|:::.||  ||..|   .||..|::.|||:|:.
Yeast   870 NWDELVKRLPPGLSMLGSVVTLGTSGFTSMQKIDEIKKF--FATKS---TKGFDQSLAQSLDTIT 929

  Fly   907 TNVQWMD 913
            :..||::
Yeast   930 SKAQWVN 936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_651689.1	M1_APN-Q_like	37..492	CDD:341064	178/468 (38%)
		ERAP1_C	577..905	CDD:463368	68/338 (20%)
APE2	NP_012765.3	M1_APN-Q_like	109..543	CDD:341064	178/469 (38%)
		ERAP1_C	614..928	CDD:463368	68/338 (20%)