DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31445 and APE2

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_012765.3	Gene:	APE2 / 853699	SGDID:	S000001640	Length:	952	Species:	Saccharomyces cerevisiae

Alignment Length:	917	Identity:	278/917 - (30%)
Similarity:	451/917 - (49%)	Gaps:	106/917 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 NHYRLPTALRPQRYYLRILTLLESPD--DLRFAGNVQIVIKALQNTR--NITLHSKNLTIDESRI 85
            |...||..:.|..|.|.:     .||  ..:|.|:|:|.:| :.|..  .:||::.:..|..::|
Yeast    98 NREILPDNVVPLHYDLTV-----EPDFKTFKFEGSVKIELK-INNPAIDTVTLNTVDTDIHSAKI 156

  Fly    86 TLRQISGAGNMDNCVSSTSVNPTHDYYI--FHTCKELLA---GNVYKLFLPFSADLTPQLFGYYR 145
                    |:    |:|:.:....:..:  |...|..::   ||.: |.:.|:..|...:.|:||
Yeast   157 --------GD----VTSSEIISEEEQQVTTFAFPKGTMSSFKGNAF-LDIKFTGILNDNMAGFYR 208

  Fly   146 SSYKDPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVRE--IRP 208
            :.|:|.:|.:|::::.||.||:.||:||||||||..||||.:||........||||.|:.  ::.
Yeast   209 AKYEDKLTGETKYMATTQMEPTDARRAFPCFDEPNLKASFAITLVSDPSLTHLSNMDVKNEYVKD 273

  Fly   209 HESLANYIWCEFQESVPMSTYLVAYSVNDFSF---KPSTLPNGALFRTWARPNAIDQCDYAAEFG 270
            .:.:.     .|..:..|||||||:.|.:..:   |...:|    .|.:|.|.......:||:..
Yeast   274 GKKVT-----LFNTTPKMSTYLVAFIVAELKYVESKNFRIP----VRVYATPGNEKHGQFAADLT 329

  Fly   271 PKVLQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVI 335
            .|.|.::|:.|||:|||||:|.:||.:||||||||||||.||...||....:|:|...|.:|.|:
Yeast   330 AKTLAFFEKTFGIQYPLPKMDNVAVHEFSAGAMENWGLVTYRVVDLLLDKDNSTLDRIQRVAEVV 394

  Fly   336 AHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVS 400
            .||||||||||||||.||..|||||||||:::.....|..|||...::.....|..|..||||.|
Yeast   395 QHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNEFQPEWKVWEQYVTDTLQHALSLDSLRS 459

  Fly   401 SHPISRPIQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWE 465
            ||||..|::...||.:.||||||.||:::|||:..::|||:|..|:.:||..:.|.||:..:||:
Yeast   460 SHPIEVPVKKADEINQIFDAISYSKGASLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTEDLWD 524

  Fly   466 SLTTAAHQNGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEIT--QERYLRNSQI-PQAD 527
            :|..|:.:        |:.::|:.||.:.||||::::.|   |..:||  |.|||..:.: |..|
Yeast   525 ALADASGK--------DVRSVMNIWTKKVGFPVISVSED---GNGKITFRQNRYLSTADVKPDED 578

  Fly   528 RVGCWWVPLSYTTQDENDFNNTSPKAWMECSSTDEGVPTTIDHSAGPEEWLILNIQLSTPYKANY 592
            :. .:.|.|:..|::..|    |.....|.|.|.|....|         :..:|.:.|..|..:|
Yeast   579 KT-IYPVFLALKTKNGVD----SSVVLSERSKTIELEDPT---------FFKVNSEQSGIYITSY 629

  Fly   593 DARNWKLL---IDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPW 654
            ....|..|   .|.|:.:|        |..|:.||...:.:|.......|.:.:....|:..:.|
Yeast   630 TDERWAKLGQQADLLSVED--------RVGLVADVKTLSASGYTSTTNFLNLVSKWNNEKSFVVW 686

  Fly   655 KSALDNLKLLNR--ILRQTPNFGSFKRYMQKLLTPIYEHL---HGMNDTFSLMTQQDEVLLKTTV 714
            ...::::..:..  :........:...:.::|::.:..||   ...:|:||  ||:    ||.|:
Yeast   687 DQIINSISSMKSTWLFEPKETQDALDNFTKQLISGMTHHLGWEFKSSDSFS--TQR----LKVTM 745

  Fly   715 VNVACQYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRK 779
            ...||....:|....|...|..:.:    .....:|..::..|:.|....|..|::..::..|..
Yeast   746 FGAACAARDADVEKAALKMFTDYCS----GNKEAIPALIKPIVFNTVARVGGAENYEKVYKIYLD 806

  Fly   780 SNVASERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIE 844
            .....|:...|.:||..||..:|:|.:...|  ...:..||..:..|.:.:.:.|......:..:
Yeast   807 PISNDEKLAALRSLGRFKEPKLLERTLGYLF--DGTVLNQDIYIPMQGMRAHQEGVEALWNWVKK 869

  Fly   845 NVELIHKYYYPQTRVMSRLLTPLSE---QVSTINDLNKFRSFANDSRHFLKGIRQAMQQSLETML 906
            |.:.:.|...|...::..::|..:.   .:..|:::.||  ||..|   .||..|::.|||:|:.
Yeast   870 NWDELVKRLPPGLSMLGSVVTLGTSGFTSMQKIDEIKKF--FATKS---TKGFDQSLAQSLDTIT 929

  Fly   907 TNVQWMD 913
            :..||::
Yeast   930 SKAQWVN 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	159/411 (39%)
		M1_APN_2	43..497	CDD:189008	178/467 (38%)
		ERAP1_C	578..904	CDD:288671	68/336 (20%)
APE2	NP_012765.3	PepN	90..941	CDD:223385	278/917 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	5	4.910