Protein Alignment CG31445 and AOPEP

DIOPT Version :10

• Sequence 1: NP_651689.1
• Gene: CG31445 / 326140
• FlyBaseID: FBgn0051445
• Length: 927
• Species: Drosophila melanogaster
• Sequence 2: NP_001372995.1
• Gene: AOPEP / 84909
• HGNCID: 1361
• Length: 859
• Species: Homo sapiens
• Alignment Length: 732
• Identity: 140/732 - (19%)
• Similarity: 242/732 - (33%)
• Gaps: 252/732 - (34%)

  Fly   110 DYYIFHT----CKELL------AGNVYKLFLPFSADLTPQLFGYYRSSYKDPVTNKTRWLS---- 160
            |||...:    |.|||      :..:.|.....:.|....:..:|::.   |......|.|
Human   204 DYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTK---PEGRSVTWTSDQSG 265

  Fly   161 ----ATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLANYIWCE-- 219
                .|...|.:.|..|||.:.|...:::..|:      .|.::..|.....:.:....:|.|
Human   266 RPCVYTVGSPINNRALFPCQEPPVAMSTWQATV------RAAASFVVLMSGENSAKPTQLWEECS 324

  Fly   220 ---FQESVPM--STYLVA-----------YSVNDFSFKPSTLPNGALFRTWARPNAIDQCDYAAE 268
               :..::||  ||:.:|           :|.||.:.:....|:.|.||   ........:|...
Human   325 SWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLATERPFSPSEANFR---HVGVCSHMEYPCR 386

  Fly   269 FG--------------------------------PKVLQYYEEFFGIRYPLPKIDQMAVP-DFSA 300
            |.                                |..|.......| .:|..::|.:.|| :|.:
Human   387 FQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLG-AHPFSRLDVLIVPANFPS 450

  Fly   301 GAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATY 365
            ..|.: ..:.:...::|....|.       ....:.||:||.|||..:..:.||:.||:|||||:
Human   451 LGMAS-PHIMFLSQSILTGGNHL-------CGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATH 507

  Fly   366 VAGL---GVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHP----ISRP---------------I 408
            :..:   ..|::.| :.:|::..|.|.:...||...:...|    :.||               |
Human   508 LEDVFWATAQQLAP-YEAREQQELRACLRWRRLQDEMQCSPEEMQVLRPSKDKTGHTSDSGASVI 571

  Fly   409 QMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQ 473
            :.....|:.|..:.|.||..:||.:...:|:|::.:.||:::..:
Human   572 KHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTF-------------------- 616

  Fly   474 NGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRNSQIPQADRVGCWWVPLSY 538
            :|.                      |.:::|:        .:..|.|  ||:..|     :.||.
Human   617 HGQ----------------------LILSQDF--------LQMLLEN--IPEEKR-----LELSV 644

  Fly   539 TTQDENDFNNTSPKAWMECSSTDEGVPTTI--DHSAGPEEWLILNIQLSTPYKANYDARNWKLLI 601
                ||.:.:     |:|.|    |:|..:  :..||.|..|...:
Human   645 ----ENIYQD-----WLESS----GIPKPLQRERRAGAECGLARQV------------------- 677

  Fly   602 DTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDNLKLLNR 666
                           ||::.      .|.|     ...:.....|||::.:..|...|.|.||..
Human   678 ---------------RAEVT------KWIG-----VNRRPRKRKRREKEEVFEKLLPDQLVLLLE 716

  Fly   667 ILRQTPNFGSFKRYMQKLLTPIYEHLHGMNDTFSLMTQQDEVLLKTTVVNVACQYDVSDCVTQAQ 731
            .|.:           ||.|:|  ..|..:..|:.|..|..||..:.      |:..|....|:|.
Human   717 HLLE-----------QKTLSP--RTLQSLQRTYHLQDQDAEVRHRW------CELIVKHKFTKAY 762

  Fly   732 AYFRRWRAETNPDENHP 748
            ....|:..|   |:..|
Human   763 KSVERFLQE---DQERP 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_651689.1	M1_APN-Q_like	37..492	CDD:341064	89/472 (19%)
		ERAP1_C	577..905	CDD:463368	32/172 (19%)
AOPEP	NP_001372995.1	GluZincin	<244..652	CDD:472708	91/495 (18%)
		Nucleolar localization signal. /evidence=ECO:0000250|UniProtKB:Q8BXQ6	689..699		2/9 (22%)
		Leuk-A4-hydro_C	721..>771	CDD:462686	15/57 (26%)