DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31445 and npepps

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_001072690.1	Gene:	npepps / 780147	XenbaseID:	XB-GENE-1008338	Length:	875	Species:	Xenopus tropicalis

Alignment Length:	923	Identity:	275/923 - (29%)
Similarity:	445/923 - (48%)	Gaps:	89/923 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RLPTALRPQRYYLRILTLLESPD--DLRFAGNVQIVIKALQNTRNITLHSKNLTIDESRITLRQI 90
            ||||.:||..|.|.:     .||  |..|.|.::..::....|..|.::..::.|    ||   .
Frog     9 RLPTDVRPVNYGLCL-----KPDLIDFTFEGKLEATVEVQNATNQIVMNCADIDI----IT---A 61

  Fly    91 SGAGNMDNCVSSTSVN-PTHDYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYKDPVTN 154
            |.|...|..:.:|..| ...|..:..:....|......|.:.|..:|..::.|:|||.|. ..|.
Frog    62 SYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQKGAGMLKIDFVGELNDKMKGFYRSKYA-TATG 125

  Fly   155 KTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLANYIWCE 219
            :.|:.:.||||.:.||:||||:|||..||:|.|.|...|...|||||.:.:.:|:....|.:..:
Frog   126 EVRYAAVTQFEATDARRAFPCWDEPAIKATFDVILIVPKDRVALSNMNLIDRKPYPDDENLVEVK 190

  Fly   220 FQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAIDQCDYAAEFGPKVLQYYEEFFGIR 284
            |..:..|||||||:.|.::.|..:...:|.|.|.:......:|..:|.|...|.|.:|:::|.:.
Frog   191 FARTPIMSTYLVAFVVGEYDFVETRSSDGVLVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVP 255

  Fly   285 YPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVT 349
            |||||||.:|:.||:||||||||||.|||:.||..|.:|..:.:|.:|.|:.|||||||||||||
Frog   256 YPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVT 320

  Fly   350 MKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHPISRPIQMVTEI 414
            |:|||.||||||||:::..|.|...:||:....:........|..||:|.:||||...:...:|:
Frog   321 MEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALENSHPIEVSVGHPSEV 385

  Fly   415 EESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQNGALPG 479
            :|.||||||.||::|:||:|.::|:|.||.|:.:||..:..|||...:|||||..|:.:
Frog   386 DEIFDAISYSKGASVIRMLHDYIGDEDFRKGMNQYLTKFQEKNAATEDLWESLEQASGK------ 444

  Fly   480 HYDINTIMDSWTLQTGFPVLNITRDYSTGTA--EITQERYLRNSQIPQADRVGCWWVPLSYTTQD 542
              .|..:|::||.|.|||::.:..:....:.  :::|:::.. |..|.:|....|.||:|..|.:
Frog   445 --PIAAVMNTWTKQMGFPLICVESEQKEDSVVLKLSQKKFCA-SGAPNSDDSYQWMVPISICTSE 506

  Fly   543 ENDFNNTSPKAWMECSSTDEGVPTTIDHSAGPEEWLILNIQLSTPYKANYDARNWKLLIDTLNSK 607
                   ||.:.......|:...|.:.....|.:|:.||......|:..|.....:.|:..:  :
Frog   507 -------SPASATVKILMDKPEMTVVLEGVKPHQWVKLNPGTVGFYRTQYSTTMLESLLPGI--R 562

  Fly   608 DFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDNLKLLNRILRQTP 672
            |. |:..::|..|.:|:...|..|..:....|:|......|.:...|.....||.:|:.:|..|.
Frog   563 DL-SLQPVDRLGLQNDLFSLARAGMINTAEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTD 626

  Fly   673 NFGSFKRYMQKLLTPIYEHL-------HGMNDTFSLMTQQDEVLLKTTVVNVACQYDVSDCVTQA 730
            .....:.:::.:.:||.:.|       .|..|          .||:..|:....:......:.:|
Frog   627 FHEEIQCFVRDVFSPIGQRLGWDPKPGEGHLD----------ALLRGLVLGKLGKAGHQPTLEEA 681

  Fly   731 QAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNVASERQTILSTLGC 795
            :..|:.     :.|..:.:..:|||.||.|.:..|.......:...::::::..|:..|...||.
Frog   682 RRRFKE-----HVDGRNVLSADLRSPVYVTVLKHGDNSTLETMMKLHKQADMQEEKNRIERVLGA 741

  Fly   796 SKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVA-SREVGFLLAKQYFIENVELIHKYYYPQTRV 859
            ..|..::::.:  ||.....:|.||:......|| ..::|...|..:..:|.|.::..|.... :
Frog   742 IAEQDLIKKVL--SFSLSEDVRPQDTVCVIGGVAGGSKLGRKCAWNFVKDNWEELYNRYQGGF-L 803

  Fly   860 MSRLLTPLSEQVSTINDLNKFRSFAND----------SRHFLKGIRQAMQQSLETMLTNVQWMDW 914
            :|||: .||           ...||:|          ..|......:.:||..|.:|.|..|:
Frog   804 ISRLI-KLS-----------LDGFASDKMAAEIKAFFDAHPAPSAERTVQQCCENILLNAGWL-- 854

  Fly   915 NYHKFSRTIRHHL 927
              .:.:..|.|:|
Frog   855 --KRDAEAIHHYL 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	156/400 (39%)
		M1_APN_2	43..497	CDD:189008	176/456 (39%)
		ERAP1_C	578..904	CDD:288671	67/343 (20%)
npepps	NP_001072690.1	Peptidase_M1	9..397	CDD:279741	156/400 (39%)
		M1_APN_2	17..460	CDD:189008	178/463 (38%)
		ERAP1_C	535..846	CDD:288671	67/343 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010