DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31445 and Lvrn

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_083284.1	Gene:	Lvrn / 74574	MGIID:	1921824	Length:	991	Species:	Mus musculus

Alignment Length:	971	Identity:	286/971 - (29%)
Similarity:	454/971 - (46%)	Gaps:	149/971 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 YNHYRLPTALRPQRYYLRILTLLE----SPDDLRFAGNVQIVIKALQNTRNITLHS--------- 75
            ::|.|||..|.|..|.|.:...|:    ||.:|.|.|.|.|.::....:..:.|||
Mouse    90 WDHLRLPPWLVPLHYDLELWPWLQPDKLSPPNLTFTGRVNITVRCTVASSRLLLHSFLLNYKQVE 154

  Fly    76 ---------KNLTIDESRITLRQISGAGNMDNCVSSTSVNPTHDYYIFHTCKELLAGNVYKLFLP 131
                     :|.|:  .|:.:.::..|             |...:.:....:.|..|:.|:|...
Mouse   155 VWGPLAQDTRNATV--GRVQVEKVWFA-------------PDMQFVVLDLGQSLEPGSRYELSFH 204

  Fly   132 FSAD-LTPQLFGYYRSSYKDPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQF 195
            ||.. |...|.|.:.:.|.|  .::.|.|.|||.||:.||..|||||||..||:|.:|:.:|..:
Mouse   205 FSGQVLQVGLEGLFLNLYHD--EDELRALVATQMEPTFARHVFPCFDEPALKATFNITVIHHPGY 267

  Fly   196 NALSNMPVREIRPHESL----ANYIWCEFQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWAR 256
            .||||||  ::...|.:    :.:....|..:..|.|||||..|.|......| ..|...|.|||
Mouse   268 AALSNMP--QLGQSERIDVNGSRWTVTTFHTTPRMPTYLVALVVCDLDHISRT-ERGKEIRVWAR 329

  Fly   257 PN--AIDQCDYAAEFGPKVLQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYS 319
            .:  |....|:||.....:..:.|:.|.|.|.|||.|.:|:|.|::||||||||:.:.||:||..
Mouse   330 KDDIASGYLDFAANITGPIFSFLEDLFNISYRLPKTDIVALPIFASGAMENWGLLIFDESSLLLE 394

  Fly   320 PTHSSLADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKG 384
            |.......:..:.::||||:.||||||||||.||.::|||||||:|.........||:.......
Mouse   395 PEDELTEKRAMILSIIAHEVGHQWFGNLVTMSWWNNIWLNEGFASYFELELTNYFYPKVPMNMIF 459

  Fly   385 SLTALMTAFRLDSLVSSHPISRPIQMVT---EIEESFDAISYQKGSAVLRMMHLFMGEESFRTGL 446
            ..|.|......|..:.|..:|..::..|   ||...||..:|:||:.:..|:..|:....|...|
Mouse   460 FFTVLHGILGEDHALESRAVSTAVENFTETSEINRLFDLYTYKKGACMAWMLASFLSPHLFINAL 524

  Fly   447 REYLKLYAYKNAEQNNLWESLTTAAHQNGA--LPGHYDINTIMDSWTLQTGFPVLNITRDYSTGT 509
            :.||:.::|.||||::||..:..|..:...  ||.  .:..||||||.:.|||:  ||.:.|||.
Mouse   525 KSYLETFSYSNAEQDDLWRHIQMAIGEQNVTHLPA--TVKGIMDSWTHRGGFPI--ITVNVSTGV 585

  Fly   510 AEITQERYLRNSQIPQADRV---------GCWWVPLSYTTQDENDFNNTSPKAWMECSSTDEGVP 565
              :.||.:       ..|:|         ..|.||:.:.   :|..  ..|..|::.|:.   :.
Mouse   586 --VKQEPF-------YLDKVENQTLLSHNSTWIVPIFWM---KNGI--PQPLVWLDKSNM---MF 633

  Fly   566 TTIDHSAGPEEWLILNIQLSTPYKANYDARNWKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWT 630
            ..:..|....:|:|||..::..|:.|||...||.|.:.| .||.::|.||||.||:.|.......
Mouse   634 PGMKLSDSDSDWVILNFNVTGYYRVNYDELGWKKLSEQL-EKDPKAIPVINRLQLVSDAFALTKN 697

  Fly   631 GEQDYETALQVTNYLRRERDLIPWKSALDNLKLLNR-ILRQTPNFGSF---KRYMQKLLTPIYEH 691
            ...:.||||.:|.|:..|.:::.|...|  |.|:|| ::....|:..:   |:|:.|....|:
Mouse   698 NYIEIETALDLTKYIAEEDEILVWFEVL--LNLINREVIYDVNNYALYPLLKKYLLKRFNSIW-- 758

  Fly   692 LHGMNDTFSLMTQQDEVLLKTT---------VVNVACQYDVSDCVTQAQAYFRRWRAETNPDENH 747
                 :|:|.:.:::...|:..         :...||...:.||:..::..|::|.|       |
Mouse   759 -----NTYSAIIRENVASLQDNYLSLFSLERIFETACWLGLEDCLQLSRELFKKWTA-------H 811

  Fly   748 P---VPLNLRSTVYCTAISQGTEEDWNFLWSRY---RKSNVASERQTILSTLGCSKEVWILQRYM 806
            |   :|..:.:.|.|:|::.|:::||:||::.|   .:....|.|:.::..:.|||:.|||.|:|
Mouse   812 PETAIPPQIENAVLCSAVALGSDKDWDFLFNLYINTTEEEDESRRRRLVHAMSCSKDPWILNRFM 876

  Fly   807 EKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIEN-VELIHKYYYPQTRVMSRLLTPLSEQ 870
            |.:....|:...:.:.:.  .||:.|||..:||.:.::| |.:..:|....   :..|:..|...
Mouse   877 EYAITAVSSNFSETNIIV--VVATSEVGRYIAKDFLMDNWVAVTERYGMDW---LDALVPVLGRT 936

  Fly   871 VSTINDLNKFRSFANDSRHFLKGI-----RQAMQQSLETMLTN-----------VQWMDWN 915
            |||...:.:.       :||...:     |..:|..|:.|.|.           |:|:..|
Mouse   937 VSTDQQVTEL-------QHFFSTVLEEHQRVVVQAKLQAMKTKNLQNKKRIARVVEWLRKN 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	142/429 (33%)
		M1_APN_2	43..497	CDD:189008	160/487 (33%)
		ERAP1_C	578..904	CDD:288671	93/350 (27%)
Lvrn	NP_083284.1	Peptidase_M1	94..504	CDD:279741	142/429 (33%)
		M1_APN_2	102..575	CDD:189008	162/494 (33%)
		Substrate binding. /evidence=ECO:0000250	376..380		3/3 (100%)
		ERAP1_C	646..964	CDD:288671	91/346 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845864
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.650