DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG31445 and ERAP2

DIOPT Version :9

Sequence 1:NP_001263064.1 Gene:CG31445 / 326140 FlyBaseID:FBgn0051445 Length:927 Species:Drosophila melanogaster
Sequence 2:NP_001123612.1 Gene:ERAP2 / 64167 HGNCID:29499 Length:960 Species:Homo sapiens


Alignment Length:941 Identity:299/941 - (31%)
Similarity:471/941 - (50%) Gaps:89/941 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 VANSISRY--NHYRLPTALRPQRYYLRILTLLESPDDLRFAGNVQIVIKALQNTRNITLHSKNLT 79
            ||.:..|:  ...|||:.:.|..|.|.:...|.|.|   |..:.:|.:.....|:.|.||||:|.
Human    55 VATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLD---FVASEKIEVLVSNATQFIILHSKDLE 116

  Fly    80 IDESRITLRQISGAGNMDNCVSSTSVNPTHDYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYY 144
            |..:.:...:.|........:...|. |.|:.......::|.....|.:.:.|.|.|.....|:|
Human   117 ITNATLQSEEDSRYMKPGKELKVLSY-PAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFY 180

  Fly   145 RSSYKDPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPH 209
            :|:|: .:..:||.|:.|.|||:.||.||||||||.|||:|.:.:....:..||||||  :::..
Human   181 KSTYR-TLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMP--KVKTI 242

  Fly   210 ESLANYIWCEFQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAIDQCDYAAEFGPKVL 274
            |.....:...|:.:|.||||||||.|.||........:|.....:|.|:..:|..||.:...|:|
Human   243 ELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYALQASLKLL 307

  Fly   275 QYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHEL 339
            .:||::|.|.|||.|:|.:|:|||:.||||||||:.|||::||:.|..||.:||..:..||||||
Human   308 DFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAHEL 372

  Fly   340 AHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHPI 404
            |||||||||||:||.|:||.||||.|:..:.|...|||... |...|.........|||.||.||
Human   373 AHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQF-DDYFLNVCFEVITKDSLNSSRPI 436

  Fly   405 SRPIQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTT 469
            |:|.:..|:|:|.||.:||.||:.:|.|:..|:|||.|:.|:.:|||.::|:||:.::||.||:.
Human   437 SKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSN 501

  Fly   470 AAHQNGALPG---HYD----------------INTIMDSWTLQTGFPVLNITRDYSTGTAEITQE 515
            :..::....|   |.|                :..:|.:||||.|.|:|.:.:|..  :..:.||
Human   502 SCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGC--SLRLQQE 564

  Fly   516 RYLRN--SQIPQ----ADRVGCWWVPLSYTTQDENDFNNTSPKAWMECSSTDEGVPTTIDHSAGP 574
            |:|:.  .:.|:    .:|. .|.:||:|:|...|..:....|     |.||     |:|.   |
Human   565 RFLQGVFQEDPEWRALQERY-LWHIPLTYSTSSSNVIHRHILK-----SKTD-----TLDL---P 615

  Fly   575 EE--WLILNIQLSTPYKANYDARNWKLLIDTLNSKDFQSIHVI----NRAQLIDDVLYFAWTGEQ 633
            |:  |:..|:..:..|..:|:...|..||..||..     |.:    :|..||.||......|..
Human   616 EKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQN-----HTLLRPKDRVGLIHDVFQLVGAGRL 675

  Fly   634 DYETALQVTNYLRRERD---LIPWKSALDNL-KLLNRILRQTPNFG-SFKRYMQKLLTPIYEHLH 693
            ..:.||.:|.||:.|..   |:...|.|::. .:::|  |...:.. :.|||:.:...|:.:. .
Human   676 TLDKALDMTYYLQHETSSPALLEGLSYLESFYHMMDR--RNISDISENLKRYLLQYFKPVIDR-Q 737

  Fly   694 GMNDTFSLMTQQDEVLLKTTVVNVACQYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVY 758
            ..:|..|:..:    :|::.::.:||..:.:.|:.:|...|.:| .|::...|  :|.::...||
Human   738 SWSDKGSVWDR----MLRSALLKLACDLNHAPCIQKAAELFSQW-MESSGKLN--IPTDVLKIVY 795

  Fly   759 CTAISQGTEEDWNFLWSRYRKSNVASERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSL 823
              ::...|...||:|..:|..|..::|:..||..|..||....|.:.:|.....| .|:.|:.:.
Human   796 --SVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGK-VIKTQNLAA 857

  Fly   824 CFQAVASREVGFLLAKQYFIENVELIHKYYYPQTRVMSRLLTPLSEQVSTINDLNK----FRSFA 884
            ...|:|.|..|..||..:..||...:.|.:...:..:..:::..:...|:.:.|.:    |.|..
Human   858 LLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLE 922

  Fly   885 NDSRHFLKGIRQAMQQSLETMLTNVQWMDWN 915
            ....|.     ...|..|||:..|::|::.|
Human   923 AQGSHL-----DIFQTVLETITKNIKWLEKN 948

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31445NP_001263064.1 Peptidase_M1 28..426 CDD:279741 161/397 (41%)
M1_APN_2 43..497 CDD:189008 184/472 (39%)
ERAP1_C 578..904 CDD:288671 77/338 (23%)
ERAP2NP_001123612.1 Peptidase_M1 68..458 CDD:279741 161/397 (41%)
M1_APN_2 76..548 CDD:189008 186/479 (39%)
Substrate binding 334..338 3/3 (100%)
ERAP1_C 621..938 CDD:288671 78/339 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155367
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100307
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X67
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.750

Return to query results.
Submit another query.