DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31445 and erap1a

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_009303348.1	Gene:	erap1a / 564068	ZFINID:	ZDB-GENE-091113-7	Length:	933	Species:	Danio rerio

Alignment Length:	986	Identity:	320/986 - (32%)
Similarity:	473/986 - (47%)	Gaps:	121/986 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KWFLLFVLAIGLDLSVANSISRYN-----------HYRLPTALRPQRYYLRILTLLESPDDLRFA 55
            |:|...::|:...|...|.....|           ..|||..::||.|.|.|...|.|   |.|.
Zfish     6 KYFHFTLVALFCALFAGNHAMTVNKNKTVLPFPWDKMRLPEIVKPQHYDLLIHPNLTS---LTFT 67

  Fly    56 GNVQIVIKALQNTRNITLHSKNLTIDESRITLRQISGAGNMDNCVSSTSVNPTHDYYIFHTCKEL 120
            |.|||.|:..|:||.|.||||||.:.:: :.|.......:.|..:|....|  ....:|......
Zfish    68 GEVQIQIEVKQDTRAIILHSKNLQVSKA-LLLGSRQHHHHQDLQISEFEAN--EQIALFSEGFTF 129

  Fly   121 LAGNVYKLFLPFSADLTPQLFGYYRSSYKDPVTN--KTRWLSATQFEPSSARKAFPCFDEPGFKA 183
            ..|: :.:.|.|.|:|:....|:|:..|   .||  :.|.|::|||||:.||.||||||||.|||
Zfish   130 EKGS-HVVHLEFYANLSDSFHGFYKGQY---TTNSGEVRMLASTQFEPTHARAAFPCFDEPAFKA 190

  Fly   184 SFVVTLGYHKQFNALSNMPVREIRPHESLANYIWCEFQESVPMSTYLVAYSVNDFSFKPSTLPNG 248
            :|.:.:....:..::||||  ::|..|.....:..:|...|.|||||||:.:.||........:|
Zfish   191 NFTIRVRRESRHISISNMP--KLRTVELADGILEDQFDTMVKMSTYLVAFIICDFHSISKKSQHG 253

  Fly   249 ALFRTWARPNAIDQCDYAAEFGPKVLQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRE 313
            .....:..|..|.|.:||.:....:|.:|:|:|.|.|||||.|..|:|||.:||||||||..|||
Zfish   254 VEISVYTVPEKISQAEYALDTAVTMLDFYDEYFDIPYPLPKHDLAAIPDFQSGAMENWGLSTYRE 318

  Fly   314 STLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEW 378
            |.||:.|..||.:||..:..|||||||||||||||||:||.|||||||||.::..:.|...:||.
Zfish   319 SGLLFDPEKSSSSDKLGITKVIAHELAHQWFGNLVTMQWWNDLWLNEGFAKFMEYVSVNITHPEL 383

  Fly   379 HSRDKGSLTALMTAFRLDSLVSSHPISRPIQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFR 443
            ...|. .|....||..:|||.||||:|.|::...||.|.||.:||:||:.:|.|:..|:..|.|:
Zfish   384 QVNDY-FLEKCFTALSVDSLSSSHPVSTPVENPAEISEMFDDVSYRKGACILNMLRDFLTPEVFK 447

  Fly   444 TGLREYLKLYAYKNAEQNNLWESLTTAAHQNGALPGH------------------------YDIN 484
            .|:..|||.::|:|...::||||||.....:|...|.                        .|:.
Zfish   448 YGIINYLKKHSYQNTVNSHLWESLTNICTSDGLDSGRLKLDGFCSKHTAETPASKWFKEDSVDVG 512

  Fly   485 TIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRNSQIPQADRVGCWWVPLSYTTQDENDFNNT 549
            .|||:||||.|||:  ||.:.......:.|||:|:.::...:... .|.|||:|.|...|.....
Zfish   513 AIMDTWTLQEGFPL--ITVEVKGQEVTLKQERFLKGAESSNSSSF-LWQVPLTYITSGSNAVQRF 574

  Fly   550 SPKAWMECSSTDEGVPTTIDHSAGPEEWLILNIQLSTPYKANYDARNWKLLIDTLNSKDFQSIHV 614
            ..|...:.....|.|           ||:..|:.|...|..:|::..|..||     |..:..|.
Zfish   575 LLKTERDVFYLPEKV-----------EWIKFNVDLRGYYIVHYESGGWDCLI-----KQLRMNHT 623

  Fly   615 I----NRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDNLKLLNRILRQTPNFG 675
            :    :||.||.|:.......:...:.||.::.||.:|.:::|.......|..|.:::.
Zfish   624 VFSSNDRASLIHDIFQLVSIEKVPLDKALNLSLYLSKESEIMPVTQGFSELVPLYKLME------ 682

  Fly   676 SFKRYMQKLLTPIYEHL----------HGMNDTFSLMTQQDEVLLKTTVVNVACQYDVSDCVTQA 730
              ||.||:|...:..||          ...:|..|:    .|.:|:..::..||......||:.|
Zfish   683 --KRDMQELENQLKSHLVKLFQPLIDRQSWSDNGSV----SERMLRNYLLLFACVRRYPSCVSTA 741

  Fly   731 QAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQG--TEEDWNFLWSRYRKSNVASERQTILSTL 793
            ...|.:|:   ..|....:|.::...||    ::|  |::.|:||..:|::|...||:..|.:.|
Zfish   742 TQLFHKWK---ESDGKMWLPTDVSLVVY----TEGARTDDGWDFLLEKYKRSVSPSEKWMIKAAL 799

  Fly   794 GCS----KEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIENVELIHKYYY 854
            ..|    |..|:|:|..|...     ::.||......:|:....||.||..:...|...:.|.:.
Zfish   800 SYSPLAHKLQWLLERSSEGEI-----MKTQDLPSMLISVSKNPKGFKLAWDFLKSNWGKLVKKFD 859

  Fly   855 PQTRVMSRLLTPLSEQVSTINDLNK----FRSFANDSRHFLKGIRQAMQQSLETMLTNVQWMDWN 915
            ..:..:||::..:::|.||...|::    |.|.|.|....|:.|    ||:||.:..|:.|||.|
Zfish   860 LGSSAISRVVVGVTDQYSTKEMLDEVELFFGSLAQDQGSGLRSI----QQALEKIQQNILWMDRN 920

  Fly   916 YHKFSRTIRHH 926
            .......:.||
Zfish   921 VPLLKAWLDHH 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	171/399 (43%)
		M1_APN_2	43..497	CDD:189008	193/479 (40%)
		ERAP1_C	578..904	CDD:288671	85/349 (24%)
erap1a	XP_009303348.1	Peptidase_M1	43..430	CDD:279741	171/399 (43%)
		M1_APN_2	52..525	CDD:189008	196/485 (40%)
		ERAP1_C	592..909	CDD:288671	85/349 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590541
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750