DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31445 and si:ch211-106j24.1

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_021327531.1	Gene:	si:ch211-106j24.1 / 555478	ZFINID:	ZDB-GENE-130530-595	Length:	960	Species:	Danio rerio

Alignment Length:	926	Identity:	325/926 - (35%)
Similarity:	503/926 - (54%)	Gaps:	75/926 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 YNHYRLPTALRPQRYYLRI--LTLLESPDDLRFAGNVQIVIKALQNTRNITLHSK--NLTIDESR 84
            ::.||||..|.||.|.:.:  ..::::.....|.|...::...::.|..|.:||.  |||:...|
Zfish    63 WDKYRLPDTLSPQYYNITLWPQMVMDANGMYIFTGISDVMFTCVKKTDLILIHSNKLNLTLFNGR 127

  Fly    85 ITLRQISG-AGNMDNCVSSTSVNPTHDYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYRSSY 148
            ..  :::| :|.....:.||.:.....|.:.....:|..|..|.|...|:.:|...|.|:|||.|
Zfish   128 HA--KLTGMSGVTAPAIKSTWLQTQTQYLVIQLKGKLNPGKSYWLHTEFTGELADDLEGFYRSEY 190

  Fly   149 KDPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLA 213
            .:....|.  ::.||.:.:.||||||||||||.||.|.:.|.:.:...||||.  :|||..:.:.
Zfish   191 MEDGEKKI--IAITQMQATYARKAFPCFDEPGMKAVFNIILIHDRGMTALSNS--QEIRTEDVII 251

  Fly   214 NYI---WCEFQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAID--QCDYAAEFGPKV 273
            :.:   ...|:.:..|||||||:.|:|||:..:....|.|.|.|||..|||  |.|||......:
Zfish   252 DEMPVTRTTFEPTARMSTYLVAFVVSDFSYINNEDKAGVLVRIWARKKAIDDGQGDYALSITQPI 316

  Fly   274 LQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHE 338
            |:::|.::...|||.|.||:|:|||::|||||||||.|||:.|||.|..|:..:||.:|.|::||
Zfish   317 LEFFESYYNTSYPLSKSDQVALPDFNSGAMENWGLVTYRETALLYDPQTSANGNKQRIATVVSHE 381

  Fly   339 LAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHP 403
            |||.|||||||:|||.|||||||||:||..||.....|.|:.:|:..|..:..||.:|||.||||
Zfish   382 LAHMWFGNLVTLKWWNDLWLNEGFASYVEYLGADHAEPTWNIKDQIILYDMQRAFAVDSLTSSHP 446

  Fly   404 ISRPIQMV---TEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWE 465
            :||..:.|   .||.|.|..|||.||:|||:|:..|:.|..|..||..|||.:|:.::..::||:
Zfish   447 LSRKEEEVNTPAEISEMFSTISYSKGAAVLKMLSEFLTEPVFAKGLSNYLKQFAFGSSVHSDLWD 511

  Fly   466 SLTTAAHQNGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYL--------RNSQ 522
            .|..:..|...:.....|:.||..|.||.||||:.|    .|.|..::|:.:|        |.|:
Zfish   512 HLQKSLDQAPGMKLPRSIHEIMSRWILQMGFPVITI----DTRTGNVSQKHFLVEKDAVVERKSE 572

  Fly   523 IPQADRVGCWWVPLSYTTQDENDFNNTSPKAWMECSSTDEGVPTTIDHSAGPEEWLILNIQLSTP 587
            ....     |:||:.:..:.:     ...:.|:...|   .:...:..|.|  ||::.|.::|..
Zfish   573 FNYE-----WFVPIKWMKKGQ-----VQDQMWLLQKS---AIHKPMKVSKG--EWVLANHKVSGY 622

  Fly   588 YKANYDARNWKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLI 652
            ::.|||..||:.|:..|.: :.|:|.|:||||::||....|.....:...||:.|.||.|||:.|
Zfish   623 FRVNYDHGNWERLLSQLET-NHQTIPVVNRAQILDDAFNLARASIINITLALRTTKYLVREREYI 686

  Fly   653 PWKSALDNLKLLNRILRQTPNFGSFKRYMQKLLTPIYEHL-----------HGMNDTFSLMTQQD 706
            ||::||.:|....::..:...:|:.:.|::|.:.|::||.           :|..|.|:
Zfish   687 PWEAALRSLNYFFQLFDRNEVYGALQAYLKKQVKPLFEHFGTISSNWTKVPNGHTDQFT------ 745

  Fly   707 EVLLKTTVVNVACQYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWN 771
                :...:::||...|..|....:::|::|.  .||..| |:..||||||||.||:.|..::||
Zfish   746 ----QIIALSLACGTGVEGCREITKSWFKKWM--QNPRVN-PIHPNLRSTVYCNAIAAGGADEWN 803

  Fly   772 FLWSRYRKSNVASERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFL 836
            |.|..::|:.||:|...:.:.|.|:|..|:|.||:|.|.:|:. |||||::.....:||..:|..
Zfish   804 FGWQMFQKATVAAEAVKLRAALACTKVPWLLNRYLEYSINPEK-IRKQDATSTIGYIASNVIGQP 867

  Fly   837 LAKQYFIENVELIHKYYYPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRH--FLKGIRQAMQ 899
            ||..:...|.:...|.|...:...|||::.::.:..|..:|::.:.|..|:..  |..| .||:|
Zfish   868 LAWDFVRANWDYFFKVYGTGSFTFSRLISDITSKFCTPFELSQLKRFQKDNAETGFGSG-TQALQ 931

  Fly   900 QSLETMLTNVQWMDWN 915
            |::|.....::|:..|
Zfish   932 QAIERTTAKIKWLAEN 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	169/410 (41%)
		M1_APN_2	43..497	CDD:189008	188/464 (41%)
		ERAP1_C	578..904	CDD:288671	107/338 (32%)
si:ch211-106j24.1	XP_021327531.1	M1_APN_2	77..543	CDD:189008	189/471 (40%)
si:ch211-106j24.1	XP_021327531.1	PepN	170..943	CDD:223385	297/811 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590567
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		mtm6446
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.850