DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31445 and si:ch211-276a23.5

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_001922987.2	Gene:	si:ch211-276a23.5 / 555317	ZFINID:	ZDB-GENE-141215-4	Length:	956	Species:	Danio rerio

Alignment Length:	983	Identity:	326/983 - (33%)
Similarity:	501/983 - (50%)	Gaps:	117/983 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FLLFVLAIG-----LDLS--------------VANSISR-------------YNHYRLPTALRPQ 36
            |:|..||:|     |.||              |.|:::.             ::.||||..|.|:
Zfish    13 FVLLALAVGSLLTILGLSLIYAQEKRRNEENMVNNTVTTLAPYSTSIPSNEPWDKYRLPDTLLPE 77

  Fly    37 RYYLRILTLLESPDDLR---FAGNVQIVIKALQNTRNITLHSKN----LTIDESRITLRQISGAG 94
            .|.:.:...| :.|||.   |.|...:....::.|..|.:||.|    ||.::....|..:  .|
Zfish    78 YYNITLWPRL-TKDDLGMYIFTGKSGVAFLCVKETDLILIHSSNLNYSLTAEKHHAELMGL--GG 139

  Fly    95 NMDNCVSSTSVNPTHDYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYKDPVTNKTRWL 159
            .....:..|......::.:....:.|..|..|.|:..|..:|...|.|:|||.|.:....|.  :
Zfish   140 TRAPVILKTWFQDQTEFMVIQLRENLQVGKSYWLYTEFQGELADDLGGFYRSEYVENGVEKV--V 202

  Fly   160 SATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLAN--YIWCEFQE 222
            :.||.:|::||.||||||||..||.|.:||.:.....||:| .:.....:.::.|  .:...|:.
Zfish   203 ATTQMQPTAARTAFPCFDEPSMKAVFHLTLIHPPGTVALAN-GMETGTENITIENQQVLQTRFEP 266

  Fly   223 SVPMSTYLVAYSVNDFSFKPSTL-PNGALFRTWARPNAID--QCDYAAEFGPKVLQYYEEFFGIR 284
            :..|||||:|:.:::|....|.| .|..|.|.|.|..||:  :.|||......||:|.|.::...
Zfish   267 TEKMSTYLLAFVISEFPSIQSPLGANKILVRIWGRREAIENGEGDYALNVTFPVLKYLESYYNTT 331

  Fly   285 YPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVT 349
            |||.|.||:|:||||||||||||||.|||:.|.|.|..||..||:.:..||:|||||.|||||||
Zfish   332 YPLSKSDQIALPDFSAGAMENWGLVTYRETFLFYEPKVSSHEDKEGVITVISHELAHMWFGNLVT 396

  Fly   350 MKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHPISR---PIQMV 411
            |:||.|||||||||:||:.|......|.|:.::...|..:..||.:|:||||||:|.   .:...
Zfish   397 MRWWNDLWLNEGFASYVSYLAADYAEPTWNIKELMVLQQVYRAFTVDALVSSHPLSSREDAVNTP 461

  Fly   412 TEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQNGA 476
            .:|||.|||::|.||:|||||:..|:.|..|..||..||:.:||.|....:||:.|...|..:|.
Zfish   462 QQIEELFDAVTYSKGAAVLRMLSEFLSESVFAKGLHNYLQEHAYSNTVYTDLWKKLQEVADSDGN 526

  Fly   477 LPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRNSQIPQA------DRVGCWWVP 535
            :.....|..||:.|.||.||||:.|    .|.|..|:|:.:|.:   |:|      |....|:||
Zfish   527 VHLPASIEEIMNRWILQAGFPVVTI----DTHTGSISQQHFLID---PEAVVNKPSDYNYEWFVP 584

  Fly   536 LSYTTQDENDFNNTSPKAWMECSSTDEGVPTTIDHSAGPEEWLILNIQLSTPYKANYDARNWKLL 600
            :::.....|     ..:.|:...||...:..|      ...|::.|:.::..|:.|||::||:.|
Zfish   585 ITWMKNGRN-----MGQHWLLNKSTSYELMKT------ETNWILANLNVTGYYRVNYDSQNWERL 638

  Fly   601 IDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDNLKLLN 665
            |..|.| |.|:|.|:||.|:|||....|.....:...||:.|.||..|::.|||:||:.||:...
Zfish   639 IKQLTS-DHQAIPVLNRGQIIDDAFTLARAKILNITMALRTTQYLSNEKEYIPWESAIRNLEYFF 702

  Fly   666 RILRQTPNFGSFKRYMQKLLTPIYEHLHGMNDTFSL-----MTQQDEVLLKTTVVNVACQYDVSD 725
            .:..:|...|..:.|:::.:.|::.:...:...::.     |.|.:::    ..:.:||:..|..
Zfish   703 LMFDRTEVRGPLEAYLRRKVEPLFHYFKVITSNWTRKPTRHMDQYNQL----NAITMACKTRVKA 763

  Fly   726 CVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNVASERQTIL 790
            |......::|:|..:.|.   :|||.:|::.|||.||:.|..|:|:|.|:.::.|.||:|.:.::
Zfish   764 CSELTSMWYRQWMKDPNV---NPVPSDLKTVVYCNAIAAGGVEEWDFGWAMFKNSTVAAEAEKLM 825

  Fly   791 STLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIENVELIHKYYYP 855
            ..|.|:||.|:|.||:..:..| :.|||||.:.....:||..:|..||..:|....:|:
Zfish   826 YGLSCTKEPWLLNRYLHYAIDP-NLIRKQDVTYPIVYIASNVIGQPLAWDFFRAKWQLM------ 883

  Fly   856 QTRVMSRLLTPLSEQVST---INDLNKFRSFANDSRHFLKGI---RQAMQQSLETMLTNVQW--- 911
             |.....|:..:.:..||   :..|.:|:....:|     |:   ..|::|::|....||:|
Zfish   884 -TTEFRVLILGIVKTFSTEFQLQQLQRFQEEVAES-----GVSLGTHAIEQAIEQTKANVKWVSE 942

  Fly   912 -----MDW 914
                 |||
Zfish   943 NKVQVMDW 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	161/412 (39%)
		M1_APN_2	43..497	CDD:189008	184/468 (39%)
		ERAP1_C	578..904	CDD:288671	97/336 (29%)
si:ch211-276a23.5	XP_001922987.2	M1_APN_2	79..547	CDD:189008	185/473 (39%)
si:ch211-276a23.5	XP_001922987.2	ERAP1_C	615..935	CDD:314669	99/340 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		mtm6446
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.820