DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31445 and ERAP1

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_005272072.1	Gene:	ERAP1 / 51752	HGNCID:	18173	Length:	951	Species:	Homo sapiens

Alignment Length:	992	Identity:	313/992 - (31%)
Similarity:	504/992 - (50%)	Gaps:	116/992 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKW------FLLFVLAIGLDLSVAN-------SISR-------YNHYRLPTALRPQRYYLRILTL 45
            :||      |||..|...|.:|..:       |..|       :|..|||..:.|..|.|.|...
Human     6 LKWSLATMSFLLSSLLALLTVSTPSWCQSTEASPKRSDGTPFPWNKIRLPEYVIPVHYDLLIHAN 70

  Fly    46 LESPDDLRFAGNVQIVIKALQNTRNITLHSKNLTIDESRITLRQISGAGNMDNCVSSTSV----N 106
            |.:   |.|.|..::.|.|.|.|..|.|||.:|.|  ||.|||:  |||..   :|...:    :
Human    71 LTT---LTFWGTTKVEITASQPTSTIILHSHHLQI--SRATLRK--GAGER---LSEEPLQVLEH 125

  Fly   107 PTHDYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYKDPVTNKTRWLSATQFEPSSARK 171
            |..:.......:.||.|..|.:.:.::.:|:....|:|:|:|:.. ..:.|.|::|||||::||.
Human   126 PRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTK-EGELRILASTQFEPTAARM 189

  Fly   172 AFPCFDEPGFKASFVVTLGYHKQFNALSNMP-VREIRPHESLANYIWCEFQESVPMSTYLVAYSV 235
            ||||||||.|||||.:.:....:..|:|||| |:.:...|.|   |...|..:|.|||||||:.:
Human   190 AFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGL---IEDHFDVTVKMSTYLVAFII 251

  Fly   236 NDFSFKPSTLPNGALFRTWARPNAIDQCDYAAEFGPKVLQYYEEFFGIRYPLPKIDQMAVPDFSA 300
            :||........:|.....:|.|:.|:|.|||.:....:|::||::|.|.|||||.|..|:|||.:
Human   252 SDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQS 316

  Fly   301 GAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATY 365
            ||||||||..||||.||:....||.:.|..:...:|||||||||||||||:||.|||||||||.:
Human   317 GAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKF 381

  Fly   366 VAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHPISRPIQMVTEIEESFDAISYQKGSAVL 430
            :..:.|...:||....|. .......|..:|:|.||||:|.|::...:|.|.||.:||.||:.:|
Human   382 MEFVSVSVTHPELKVGDY-FFGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACIL 445

  Fly   431 RMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTT--------------AAHQNGALPGHY 481
            .|:..::..::|::|:.:||:.::|||.:..:||:|:.:              :..|:.:...|:
Human   446 NMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHW 510

  Fly   482 -----DINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRNSQIPQADRVGCWWVPLSYTTQ 541
                 |:.|:|::||||.|||::.||  .......:.||.|::.|. ...|....|.|||::.|.
Human   511 HQEGVDVKTMMNTWTLQKGFPLITIT--VRGRNVHMKQEHYMKGSD-GAPDTGYLWHVPLTFITS 572

  Fly   542 DENDFNNTSPKAWMECSSTDEGVPTTIDHSAGPE--EWLILNIQLSTPYKANYDARNWKLLIDTL 604
            ..:..:....|             |..|....||  ||:..|:.::..|..:|:...|..|...|
Human   573 KSDMVHRFLLK-------------TKTDVLILPEEVEWIKFNVGMNGYYIVHYEDDGWDSLTGLL 624

  Fly   605 NSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDNL----KL-- 663
            .. ...::...:||.||::.......|:...|.||.::.||:.|.:::|....|:.|    ||
Human   625 KG-THTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLNELIPMYKLME 688

  Fly   664 ---LNRILRQTPNFGSFKRYMQKLLTPIYEHLHGMNDTFSLMTQQDEVLLKTTVVNVACQYDVSD 725
               :|.:..|      ||.::.:||..:.:     ..|::......|.:|::.::.:||.::...
Human   689 KRDMNEVETQ------FKAFLIRLLRDLID-----KQTWTDEGSVSERMLRSQLLLLACVHNYQP 742

  Fly   726 CVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNVASERQTIL 790
            ||.:|:.|||:|: |:|.:.:.||.:.|  .|:  |:...:.|.|:||:|:|:.|..::|:..|.
Human   743 CVQRAEGYFRKWK-ESNGNLSLPVDVTL--AVF--AVGAQSTEGWDFLYSKYQFSLSSTEKSQIE 802

  Fly   791 STLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIEN-VELIHKYYY 854
            ..|..::....||..:::|| ....|:.|:.......:....||:.||.|:..:| .:|:.|:..
Human   803 FALCRTQNKEKLQWLLDESF-KGDKIKTQEFPQILTLIGRNPVGYPLAWQFLRKNWNKLVQKFEL 866

  Fly   855 PQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRHFLKGIRQAMQQSLETMLTNVQWMDWNY--- 916
            ..:.: :.::...:.|.||...|.:.:.|.:..:.....:| .:||::||:..|:.|||.|:
Human   867 GSSSI-AHMVMGTTNQFSTRTRLEEVKGFFSSLKENGSQLR-CVQQTIETIEENIGWMDKNFDKI 929

  Fly   917 ------HKFSRTIRHHL 927
                  .|..|::.|.|
Human   930 RVWLQSEKLERSLYHRL 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	167/402 (42%)
		M1_APN_2	43..497	CDD:189008	184/477 (39%)
		ERAP1_C	578..904	CDD:288671	79/335 (24%)
ERAP1	XP_005272072.1	M1_APN_2	61..531	CDD:189008	187/484 (39%)
ERAP1	XP_005272072.1	ERAP1_C	597..916	CDD:314669	82/338 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155389
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.750