DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31445 and CG46339

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster

Alignment Length:	917	Identity:	300/917 - (32%)
Similarity:	476/917 - (51%)	Gaps:	68/917 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 RPQRYYLRILTLLESPDDLRFAGNVQIVIKALQNTRNIT------LHSKNLTIDESRITLRQISG 92
            ||..|     :||..|.......|..:.|:..::...:|      |...|::|...|:......|
  Fly   295 RPLHY-----SLLIEPSVATSISNGSLTIEIERDVSKVTSWEPIVLDVHNVSISNVRVIRALADG 354

  Fly    93 AGNMDNCVSSTSVNPTHDY------YIFHTCKELLAGNVYK--LFLPFSADLTPQLFGYYRSSYK 149
            |.|..   ....::...||      ::.:..|.|......:  |.|.|.:.:|..|.|.|::||.
  Fly   355 ASNAS---EEQDLDFDSDYGEDNATFVINLSKTLAVETQLRVLLSLDFVSQVTDTLQGIYKTSYT 416

  Fly   150 DPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFN-ALSNMP---VREIRPHE 210
            :|.|....|:.:|||.|..||:||||||.|..||:|.:::....||. ||||||   .|..|
  Fly   417 NPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSGSRRFR--- 478

  Fly   211 SLANYIWCEFQESVPMSTYLVAYSV-NDFSFKPSTLPNGALFRT--WARPNAIDQCDYAAEFGPK 272
              ..:|..:|:.:..|.|||||:.| |....:.::..:|...|.  |.||..:....||.:...|
  Fly   479 --RGFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRPQFVGMTHYAYKMVRK 541

  Fly   273 VLQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADK----QDLAN 333
            .|.|||:||||:..|||||.::||||...|||||||:.:|:|.||. |....||..    |.:|.
  Fly   542 FLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLV-PEDLQLASSSEHMQVVAG 605

  Fly   334 VIAHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSL 398
            :|||||||||||||||.|||.||||.||||.|::...::..:||:.|.|..::.....:...|:.
  Fly   606 IIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEFKESMEHDAD 670

  Fly   399 VSSHPISRPIQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNL 463
            .:||.||..::...::...||.|||.||:.:|||::..:|:.:||:..|:.||.:||.|.::::|
  Fly   671 NTSHAISFDVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDL 735

  Fly   464 WESLTTAAHQNGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRNSQIPQADR 528
            |..||...|:.|.||....:..|||||..|.|:||:|:.|  ......:.|||||..|: ..||:
  Fly   736 WAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVVNVER--RGADLVLRQERYLLPSK-NTADQ 797

  Fly   529 VGCWWVPLSYTTQDENDFNNTSPKAWMECSSTDE-GVPTTIDHSAGPEEWLILNIQLSTPYKANY 592
             ..|::|:::.| ||....:..|..||.....:| .|.....||:..:..:.||:.....|:.||
  Fly   798 -STWFIPITFET-DELRKGDNIPTHWMRSEDEEELIVGNVFAHSSNSDNVIYLNLNRQGYYRVNY 860

  Fly   593 DARNWKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIP---- 653
            |..:|..|     .|:|.::..|.||||:||.|:.:......|:..|   .:|....|.:.
  Fly   861 DMTSWLAL-----KKNFSTLPRITRAQLLDDALHLSQAEYLTYDIPL---TFLMELFDAVDDELL 917

  Fly   654 WKSALDNLKLLNRILRQTPNFGSFKRYMQKLLTPIYEH--LHGMNDTFSLMTQQDEVLLKTTVVN 716
            |.:|...|..|...|::.|.:.:|:.:|:.::.|.::|  ||..::...|..:.     :..|..
  Fly   918 WIAAKPGLNYLIYNLKREPAYETFRAFMKFIVRPAFDHYGLHEPDNESHLQLKH-----RALVAY 977

  Fly   717 VACQYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSN 781
            .||:::...|..:||..||.|..:   .:|:|:..||:|.:|||::::|:..:|.|.:.:|:.:.
  Fly   978 FACKFNYDRCTQKAQMKFREWMRD---PKNNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTT 1039

  Fly   782 VASERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIENV 846
            .|||::.||::|||:.:.|:|.:|:..:.:|.|.|.|||.:|.|:||||..:|..:|..:...|:
  Fly  1040 SASEKEEILTSLGCTTKPWLLSKYLNMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNI 1104

  Fly   847 ELIHKYYYPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRHF-LKGIRQAMQQSLETMLTNVQ 910
            :.|.:||......:|.::..|:..::.....::....|...|.. |..:..|::.:||.:..|:.
  Fly  1105 KEIVEYYGDGFSTLSEMIKSLTIYMNKDYHKHQLLDLAATCRKLGLHAVESAIELALEQVNNNIY 1169

  Fly   911 WMDWNYH 917
            |...:||
  Fly  1170 WRSHSYH 1176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	150/416 (36%)
		M1_APN_2	43..497	CDD:189008	176/478 (37%)
		ERAP1_C	578..904	CDD:288671	92/332 (28%)
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	149/415 (36%)
		M1_APN_2	297..769	CDD:189008	177/485 (36%)
		ERAP1_C	846..1138	CDD:288671	87/307 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462095
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	8	7.850