DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31445 and rnpep

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_001002741.1	Gene:	rnpep / 437014	ZFINID:	ZDB-GENE-040718-241	Length:	626	Species:	Danio rerio

Alignment Length:	762	Identity:	165/762 - (21%)
Similarity:	279/762 - (36%)	Gaps:	218/762 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DLSVANSISRY--NHYRLPTALRPQRYYLRILTLLESPDDLRFAGNVQIVIKALQNTRN---ITL 73
            |::.::|..::  .|:.|.         |::..|.:|     .:|...|.::.:|::::   :.:
Zfish    16 DVATSSSFRQFKIEHFHLD---------LKVDFLQKS-----ISGTETIELQCIQDSQSELQLDI 66

  Fly    74 HSKNLTIDESRITLRQISGAGNMDNCVSSTSVN-PTHDYYIFHTCKELLAGNVYKLFLPFSADLT 137
            | .:|::.|  |||.|        |....|... .|.|:..:.|  .||.    |....||:|..
Zfish    67 H-PSLSVHE--ITLSQ--------NARDWTRTEFLTQDFTSYGT--TLLV----KFPTAFSSDDK 114

  Fly   138 PQLFGYYRSS------YKDP--VTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQ 194
            .||...|.::      :.:|  ...|.:....||.:....|..|||||.|..|:::...:.....
Zfish   115 LQLAIRYTATDGPGVCWLEPEQTAGKLKPYVFTQGQAVLNRSCFPCFDTPAVKSTYSAAVQVPDG 179

  Fly   195 FNALSNMPVREIRPHESLANYIWCEFQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARP-- 257
            |.|:  |...:....::...::   |....|:..||||.:|.|.    .:...|...|.|..|
Zfish   180 FTAV--MSANKWEQRKADGAFL---FTMEHPIPAYLVALAVGDL----QSAEVGPRTRVWTEPCL 235

  Fly   258 ---------NAIDQCDYAAE--FGPKVLQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKY 311
                     |.|:......|  |||.|...|:..|     :|       |.|..|.|||
Zfish   236 LQAAKQEYDNVIEDFLSVGEKLFGPYVWGRYDVLF-----MP-------PSFPFGGMEN------ 282

  Fly   312 RESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYP 376
               ..|...|...||..:.||:||.||:.|.|||||||...|.|.||||||..|......:|:|.
Zfish   283 ---PCLTFVTPCLLAGDRSLADVIVHEICHSWFGNLVTNATWGDFWLNEGFTMYAQRRVCRELYG 344

  Fly   377 EWHSRDKGSLTALMTAFRLDSLVSSHPISR---PIQMVTEIEESFDAISYQKGSA-VLRMMHLFM 437
            |.::..:.:....:....:|:....||:::   .|:...:.:::::...|:||.. |..:.||..
Zfish   345 EAYTCLEAATGKALLRQHMDNTGEDHPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLTG 409

  Fly   438 GEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQNGALPGHYDINTIMDSWTLQTGFPVLNIT 502
            .:..|.|.|:.|::.:.:::.
Zfish   410 DQSRFDTFLKAYVEKFKFRSV-------------------------------------------- 430

  Fly   503 RDYSTGTAEITQERYLRNSQIPQADRVGCWWVPLSYTTQDEN-------DFNNTSPKAWMECSST 560
                  .||...|.||  ...|:              .::.|       ||:     :|:.....
Zfish   431 ------LAEDALEFYL--EYFPE--------------LKERNVHKIEGLDFD-----SWLNVPGW 468

  Fly   561 DEGVPTTIDHSAG----------PEEWLILNIQLSTPYKANYDARNWKLLIDTLNSKDFQSIH-- 613
            ...||   |.|||          .|:||..|:.|.:..|.  |.::|         |.:|:::
Zfish   469 PPYVP---DLSAGQTLMKPAELLAEKWLSHNLDLESICKT--DLKSW---------KTYQTVYFL 519

  Fly   614 --VINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDNLKLLNRILRQTPNFGS 676
              ::.::.|.|..|...   |:.|...::..|...:.|    |...:..       .:.:|.|..
Zfish   520 DRILEKSPLPDGNLKKL---EECYSQIIKSNNAELKVR----WAQIVAK-------NQYSPGFQH 570

  Fly   677 FKRYM-----QKLLTPIYEHL-HGMNDTFSLMTQQDEVLLKTTVVNV 717
            .:.::     ||...|:|..| :|..:|.:|..:..........|||
Zfish   571 IRDFLSSQGKQKYTLPVYRALWNGSEETKALAIEMFSATSGQLHVNV 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	106/425 (25%)
		M1_APN_2	43..497	CDD:189008	113/482 (23%)
		ERAP1_C	578..904	CDD:288671	29/150 (19%)
rnpep	NP_001002741.1	leuko_A4_hydro	16..623	CDD:274120	165/762 (22%)
		M1_LTA4H	16..464	CDD:189006	128/579 (22%)
		Leuk-A4-hydro_C	484..624	CDD:286244	31/159 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590600
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740