DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31445 and npepps

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_001157499.1	Gene:	npepps / 407726	ZFINID:	ZDB-GENE-060524-3	Length:	872	Species:	Danio rerio

Alignment Length:	899	Identity:	270/899 - (30%)
Similarity:	443/899 - (49%)	Gaps:	68/899 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RLPTALRPQRYYLRILTLLESPD--DLRFAGNVQIVIKALQNTRNITLHSKNLTIDESRITLRQI 90
            ||||.:.|..|.||:     .||  |..|.|.::..::..|.|..|.::..::.|    ||...:
Zfish     9 RLPTDVYPVNYGLRL-----KPDLVDFTFEGKLEAAVEVTQGTNQIVMNCADIDI----ITASFV 64

  Fly    91 SGAGNMDNCVSSTSVN-PTHDYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYKDPVTN 154
            ...|..   :::|..| ...|..:.......|......|.:.|..:|..::.|:|||.|..  :.
Zfish    65 PDGGEE---INATGFNYQNEDEKVTLCFPSTLQKGSGSLKIDFVGELNDKMKGFYRSKYSS--SG 124

  Fly   155 KTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLANYIWCE 219
            :.|:.:.||||.:.||:||||:|||..||:|.:||...|...|||||.|.:.:|:....:.:..:
Zfish   125 EVRYAAVTQFEATDARRAFPCWDEPAIKATFDITLIVPKDRVALSNMNVVDRKPYAEDQSLVEVK 189

  Fly   220 FQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAIDQCDYAAEFGPKVLQYYEEFFGIR 284
            |..:..|||||||:.:.::.|..|...:|...|.:......:|..:|.|...|.|.:|:::|.:.
Zfish   190 FATTPIMSTYLVAFVIGEYDFVESQSSDGVTVRVYTPVGKAEQGKFALEVATKTLPFYKDYFSVP 254

  Fly   285 YPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVT 349
            |||||||.:|:.||:||||||||||.|||:.||..|.:|..:.:|.:|.|:.|||||||||||||
Zfish   255 YPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCASSRQWVALVVGHELAHQWFGNLVT 319

  Fly   350 MKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHPISRPIQMVTEI 414
            |:|||.||||||||:::..|.|...:||:....:........|..||:|.:||||...:...:|:
Zfish   320 MEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRALDLDALDNSHPIEVDVGHPSEV 384

  Fly   415 EESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQNGALPG 479
            :|.||||||.||::|:||:|.::|:|.||.|:..||..:.:|||...:|||.|..|:.:
Zfish   385 DEIFDAISYSKGASVIRMLHNYIGDEDFRKGMNAYLLKFQHKNASTEDLWECLEQASGK------ 443

  Fly   480 HYDINTIMDSWTLQTGFPVLNITRDY--STGTAEITQERYLRNSQIPQADRVGC--WWVPLSYTT 540
              .|..:|:|||.|.|||::.:.::.  |....:|:|:::..:.  |:.|. .|  |.||:|..|
Zfish   444 --PIAAVMNSWTKQMGFPIIVVDQEQHGSDRVLKISQKKFCASG--PRNDE-DCPNWMVPISICT 503

  Fly   541 QDENDFNNTSPKAWMECSST----DEGVPTTIDHSAGPEEWLILNIQLSTPYKANYDARNWKLLI 601
            .::           ..|:.|    |:...|....:..|:.|:.:|......|:..|.:...:.|:
Zfish   504 SED-----------PSCTKTKILLDQPETTVNITNVAPDHWIKINPGTVGFYRIQYSSAMLESLL 557

  Fly   602 DTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDNLKLLNR 666
            ..:  :|. ::..::|..|.:|:...|..|.......|:|......|.:...|.....||.:|:.
Zfish   558 PGI--RDL-TLLPVDRLGLQNDLFSLARAGMISTVEVLKVMEAFVNEPNYTVWSDLSCNLGVLSS 619

  Fly   667 ILRQTPNFGSFKRYMQKLLTPIYEHLHGMNDTFSLMTQQD--EVLLKTTVVNVACQYDVSDCVTQ 729
            :|..|......:.:::.|.|||     ||...:...|.:.  :.||:..|:....:......:.:
Zfish   620 LLSHTDFHEDIQEFIRDLFTPI-----GMKLGWDSRTGEGHLDALLRGLVLGKLGKAGHKATLEE 679

  Fly   730 AQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNVASERQTILSTLG 794
            |:..||.     :.:....:..:|||.||.|.:..|.....:.:...::::::..|:..|...||
Zfish   680 ARRRFRE-----HVEGKQILSADLRSPVYLTVLKHGDSTTLDTMLKLHKQADMQEEKNRIERVLG 739

  Fly   795 CSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVA-SREVGFLLAKQYFIENVELIHKYYYPQTR 858
            ......::||.:  :|.....:|.||:......|| |.:.|...|.::..:|.|.:|..|....
Zfish   740 AIPAPDLIQRVL--NFALSEEVRPQDTVSVIGGVAGSSKQGRKAAWKFVKDNWEELHNRYQGGF- 801

  Fly   859 VMSRLLTPLSEQVSTINDLNKFRSFANDSRHFLKGIRQAMQQSLETMLTNVQWM 912
            ::|||:....:..:......:.:||...  |......:.:||..|.:|.|..|:
Zfish   802 LISRLIKLTVDGFAIDKMAAEVKSFFES--HHAPAAERTVQQCCENILLNAAWL 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	153/400 (38%)
		M1_APN_2	43..497	CDD:189008	173/456 (38%)
		ERAP1_C	578..904	CDD:288671	66/328 (20%)
npepps	NP_001157499.1	Peptidase_M1	9..396	CDD:279741	153/400 (38%)
		M1_APN_2	17..459	CDD:189008	176/463 (38%)
		ERAP1_C	534..845	CDD:288671	66/328 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820