DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31445 and LTA4H

DIOPT Version :9

Sequence 1:NP_001263064.1 Gene:CG31445 / 326140 FlyBaseID:FBgn0051445 Length:927 Species:Drosophila melanogaster
Sequence 2:NP_000886.1 Gene:LTA4H / 4048 HGNCID:6710 Length:611 Species:Homo sapiens


Alignment Length:616 Identity:139/616 - (22%)
Similarity:245/616 - (39%) Gaps:137/616 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 SISRYNHYRLPTALRPQRYYLRILTLLESPDDLRFAGNVQIVIKALQ-NTRNITLHSKNLTIDES 83
            |:.|..|..|..::...|   |.||           |...:.:::.: |.|::.|.:|:|||::.
Human    15 SVCRTKHLHLRCSVDFTR---RTLT-----------GTAALTVQSQEDNLRSLVLDTKDLTIEKV 65

  Fly    84 RITLRQISGA-GNMDNCVSSTSVNPTHDYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYRSS 147
            .|..:::..| |.                      ::...|:..::.||.:.....::  ....|
Human    66 VINGQEVKYALGE----------------------RQSYKGSPMEISLPIALSKNQEI--VIEIS 106

  Fly   148 YK-DPVTNKTRWLSATQ---------FEPSSA---RKAFPCFDEPGFKASFVVTLGYHKQFNALS 199
            :: .|.::..:||:..|         |....|   |...||.|.|..|.::...:...|:..||.
Human   107 FETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALM 171

  Fly   200 NMPVR--EIRPHESLANYIWCEFQESVPMSTYLVAYSVNDFSFK---PSTLPNGALFRTWARPNA 259
            : .:|  |....|..:..|: :|.:.||:..||:|..|.....:   |.||       .|:....
Human   172 S-AIRDGETPDPEDPSRKIY-KFIQKVPIPCYLIALVVGALESRQIGPRTL-------VWSEKEQ 227

  Fly   260 IDQCDYAAEFGPKVLQYYEEFFGIRYPLPKIDQMAV-PDFSAGAMENWGLVKYRESTLLYSPTHS 323
            :::..|.......:|:..|:..| .|...:.|.:.: |.|..|.|||         ..|...|.:
Human   228 VEKSAYEFSETESMLKIAEDLGG-PYVWGQYDLLVLPPSFPYGGMEN---------PCLTFVTPT 282

  Fly   324 SLADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPE--WHSRDKGSL 386
            .||..:.|:||||||::|.|.|||||.|.|...|||||...|:.......::.|  .|....|..
Human   283 LLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGW 347

  Fly   387 TALMTAFRLDSLVSSHPISRPIQMVTEIEE--SFDAISYQKGSAVL-RMMHLFMGEESFRTGLRE 448
            ..|..:.:  :...:||.::.:..:|:|:.  ::.::.|:||.|:| .:..|..|.|.|...|:.
Human   348 GELQNSVK--TFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKA 410

  Fly   449 YLKLYAYKNAEQNNLWESLTTAAHQNGALPGHYDINTIMD--SWTLQTGFPVLNITRDYSTGTAE 511
            |::.::||:...:: |:....:..::     ..|:...:|  :|....|.|.:....|.:     
Human   411 YVEKFSYKSITTDD-WKDFLYSYFKD-----KVDVLNQVDWNAWLYSPGLPPIKPNYDMT----- 464

  Fly   512 ITQERYLRNSQIPQADRVGCWWVPLSYTTQDENDFNNTSPKAWMECSS---------TDEGVPTT 567
                  |.|:.|..:.|    |:     |..|:|.|:.:.....:.||         |.:..|..
Human   465 ------LTNACIALSQR----WI-----TAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLP 514

  Fly   568 IDHSAGPEE---------------WLILNIQ 583
            :.|....:|               ||.|.||
Human   515 LGHIKRMQEVYNFNAINNSEIRFRWLRLCIQ 545

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31445NP_001263064.1 Peptidase_M1 28..426 CDD:279741 97/422 (23%)
M1_APN_2 43..497 CDD:189008 111/481 (23%)
ERAP1_C 578..904 CDD:288671 4/6 (67%)
LTA4HNP_000886.1 leuko_A4_hydro 6..608 CDD:274120 139/616 (23%)
Substrate binding. /evidence=ECO:0000269|PubMed:18804029 135..137 0/1 (0%)
Substrate binding. /evidence=ECO:0000269|PubMed:18804029 267..272 1/4 (25%)
Inhibitor ARM1 binding. /evidence=ECO:0000269|PubMed:24591641 362..365 1/2 (50%)
Substrate binding. /evidence=ECO:0000269|PubMed:18804029 564..566
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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