Protein Alignment CG31445 and LNPEP

DIOPT Version :10

• Sequence 1: NP_651689.1
• Gene: CG31445 / 326140
• FlyBaseID: FBgn0051445
• Length: 927
• Species: Drosophila melanogaster
• Sequence 2: XP_054208557.1
• Gene: LNPEP / 4012
• HGNCID: 6656
• Length: 1097
• Species: Homo sapiens
• Alignment Length: 922
• Identity: 313/922 - (33%)
• Similarity: 477/922 - (51%)
• Gaps: 105/922 - (11%)

  Fly    28 RLPTALRPQRYYLRILTLLESPDDLRFAGNVQIVIKALQNTRNITLHSKNLTIDESRITLRQISG 92
            |||||:.|.||.|.:...|.|   :.|.|:|.|.::|||.|.||.|||....|  ||:|..
Human   239 RLPTAVVPLRYELSLHPNLTS---MTFRGSVTISVQALQVTWNIILHSTGHNI--SRVTFM---- 294

  Fly    93 AGNMDNCVSSTSVNPTHDYYIFH------TCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYKDP 151
                 :.|||.........|.:|      ..:.||||:.|.|.:.:||:::...:|:|..||.|.
Human   295 -----SAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDE 354

  Fly   152 VTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLA--- 213
             :|:.::.:||||||.:||.||||||||.|||:|::.:...:|:.||||||.:     .|:.
Human   355 -SNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKK-----SSVVLDD 413

  Fly   214 NYIWCEFQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAIDQCDYAAEFGPKVLQYYE 278
            ..:..||.|||.|||||||:.|.:.. ..|...||.|...:|.|..|.|..||.|...|:|::::
Human   414 GLVQDEFSESVKMSTYLVAFIVGEMK-NLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQ 477

  Fly   279 EFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQW 343
            .:|.|:|||.|:|.:|:|||.|||||||||:.:||.||||....||:||::.:..:|||||||||
Human   478 NYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQW 542

  Fly   344 FGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHPISRPI 408
            ||||||||||.||||||||||::....:::|:.|..|.: ..|.|.....:.|||.||||||..:
Human   543 FGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYE-DFLDARFKTMKKDSLNSSHPISSSV 606

  Fly   409 QMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQ 473
            |...:|||.||::||.|||::|.|:..::.|:.|:..:..||..::|.:.:.::||:|.....:|
Human   607 QSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQ 671

  Fly   474 NGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRN--SQIPQADRVGCWWVPL 536
            .      .|:..:|.:||||.|||::.:.:  ......|.|||:..|  .:|..:|....|.:||
Human   672 T------LDVKRMMKTWTLQKGFPLVTVQK--KGKELFIQQERFFLNMKPEIQPSDTSYLWHIPL 728

  Fly   537 SYTTQDENDFNNTSPKAWMECSSTDEGVPTTIDHSAG----PEE--WLILNIQLSTPYKANYDAR 595
            ||.|:..|             .|..:.| :.:|..:|    .||  |:.:||.::..|..:|...
Human   729 SYVTEGRN-------------YSKYQSV-SLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADD 779

  Fly   596 NWKLLID-------TLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIP 653
            :|:.||.       .|:.||        ||.||:::...|..|:...:.|..:.|||..|....|
Human   780 DWEALIHQLKINPYVLSDKD--------RANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAP 836

  Fly   654 WKSALDNLKLLNRILRQTPNFGSFKRYMQKLLTPIYEHLHGMNDTFSLMTQQDEVL-----LKTT 713
            ...||....|:..:|.:.    .:.....:|:|.:::.|   .:.....|..||..     |::.
Human   837 ITEALFQTDLIYNLLEKL----GYMDLASRLVTRVFKLL---QNQIQQQTWTDEGTPSMRELRSA 894

  Fly   714 VVNVACQYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYR 778
            ::..||.:::.:|.|.|...|..|.|...   ...:|.::.:||:  .:...|::.|:||..:|.
Human   895 LLEFACTHNLGNCSTTAMKLFDDWMASNG---TQSLPTDVMTTVF--KVGAKTDKGWSFLLGKYI 954

  Fly   779 KSNVASERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFI 843
            .....:|:..||..|..|::|..|...|:.|.:..: .|.|..|...:.|.....|.|||..:..
Human   955 SIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDN-FRTQKLSFIIRTVGRHFPGHLLAWDFVK 1018

  Fly   844 EN-VELIHKY----YYPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRHFLKGIRQAMQQSLE 903
            || .:|:.|:    |..|..|...  |.|....:.::::..|  |.|.|....:  .:.:|::||
Human  1019 ENWNKLVQKFPLGSYTVQNIVAGS--TYLFSTKTHLSEVQAF--FENQSEATFR--LRCVQEALE 1077

  Fly   904 TMLTNVQWMDWN 915
            .:..|:|||:.|
Human  1078 VIQLNIQWMEKN 1089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_651689.1	M1_APN-Q_like	37..492	CDD:341064	193/463 (42%)
		ERAP1_C	577..905	CDD:463368	83/344 (24%)
LNPEP	XP_054208557.1	M1_APN-Q_like	247..684	CDD:341064	193/464 (42%)
		ERAP1_C	761..1081	CDD:463368	83/346 (24%)