DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31445 and CG6071

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster

Alignment Length:	984	Identity:	274/984 - (27%)
Similarity:	449/984 - (45%)	Gaps:	152/984 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LRPQRYYLRILTLLESPDDL-RFAGNVQIVIKALQNTRNITLHSKNLTIDESRITL------RQI 90
            ::|.||.|.|||.|.|.|:. :|.|.|.|.|:|.|.||.|.|:|.|:||...|..:      |:|
  Fly    22 VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKI 86

  Fly    91 SGAGNMDNCVSSTSVNPTHDYYIFHTCK-----ELLAGNVYKLFLPFSADL-TPQLFGYYRSSY- 148
             ||..:...:..||:           .|     .|.:|.:|.|.:.||.:| ..|.:||:...|
  Fly    87 -GALQIKRIIKKTSL-----------IKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYYD 139

  Fly   149 KDPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLA 213
            |.|..    :.|||:.||..|...|||||:|.|:..:.:||.:.:::.||||||..|.:|::.:.
  Fly   140 KTPRV----FYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIE 200

  Fly   214 NYIWCEFQESVPMSTYLVAYSVNDFSFKPSTLP--NGALFRTWARPNAIDQCDYAAEFGPKVLQY 276
            ||:...|..|.|::|..|.::::... |..:.|  .|.....|:||:..::.....|..|.:...
  Fly   201 NYVSTTFMGSPPLATQQVMWTLHQLE-KVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSK 264

  Fly   277 YEEFFGIRYPLP-------KIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANV 334
            ||..|.  ||||       |:|.:.:|.::. .....|::.|.|..:     .|.....:.|...
  Fly   265 YETLFA--YPLPKGADWGGKVDHVVLPRYTE-MYSGQGIMVYGEDIV-----DSGQNGLESLQET 321

  Fly   335 IAHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSL-TALMTAFRLDSL 398
            :|..:|.||.|.||.::...:.::..|...|   |.||.:     :.||.:. |..::..|||.|
  Fly   322 LAELVARQWNGLLVNLEDSDEEYVRNGINYY---LSVQVM-----AMDKEAYNTTHLSKTRLDVL 378

  Fly   399 VSSHPISRPIQMVTEIEES-FDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNN 462
            ... .:::...:.|:::|| ...:..:|...::.|:.:.:|::.|..||:|:.|.||..:|....
  Fly   379 YHD-SLAKVKSIATDVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKE 442

  Fly   463 LWESLTTAAHQNGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQER----YLRNSQI 523
            |||.....|.::..||....:.|:|:||..|.|||:|.:.||.:.....|||.|    ||.||.
  Fly   443 LWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSS- 506

  Fly   524 PQADRVGCWWVPLSYTTQDENDFNNTSPKA-WMECSSTDEGVPTTIDHSAGPEEWLILNIQLSTP 587
                 ..|||||::|..:     |.|.|:. |:.|......: ..:.|.|.||:||::|:..:.|
  Fly   507 -----NDCWWVPVAYIVR-----NLTLPQVEWLGCQKNSRDI-LELSHIANPEDWLLINVDAAVP 560

  Fly   588 YKANYDARNWKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLI 652
            .:..||:.|.:|:.:.|. :||..|..::|.||:||.|..:|:|...|...|.|.:||..|..::
  Fly   561 LRVFYDSYNLQLISEALR-QDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVL 624

  Fly   653 PWKSALDNLKLLNRILRQTPNFGSFKRYMQKLLTPIY---------------------------- 689
            .|::||.||:.|..|:|.|..|..||.|||||:.|.:
  Fly   625 VWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTE 689

  Fly   690 --------------------------------EHLHGMNDTFSLMTQQDEVLLKTTVVNVACQYD 722
                                            :.....:.|.|..|.:.::.|...:..:|||::
  Fly   690 SSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFE 754

  Fly   723 VSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNVASERQ 787
            :.:|:|.||   :|::|..:...:..:|..:|..|.|..|..|.|..|..:...:.:|....||.
  Fly   755 IKECLTDAQ---QRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERS 816

  Fly   788 TILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIENVELIHKY 852
            .:|::|.|:.|.|.:|:.:..:...|...|...:|| ..||....:|:.:.||:.|:     |..
  Fly   817 ILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASL-LSAVLRSPLGYYVGKQFLID-----HSK 875

  Fly   853 YYPQTRVMSRLLTPLSEQVSTINDLNKFRSFAND--SRHFLKGIRQAMQQSLETMLTNVQWMDWN 915
            ...:::.:..:|||....:||..:.    |..||  .|:....:...:..:||:.|..|.|.:..
  Fly   876 EILRSKDVKLILTPFINAMSTKAEF----SALNDHLHRNLPSSMVSGLSSTLESGLDRVNWRNNL 936

  Fly   916 YHKFSRTIR 924
            |....:.||
  Fly   937 YFDLLKAIR 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	121/417 (29%)
		M1_APN_2	43..497	CDD:189008	139/478 (29%)
		ERAP1_C	578..904	CDD:288671	94/387 (24%)
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	143/485 (29%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	96/391 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449992
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850