DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31445 and Psa

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster

Alignment Length:	925	Identity:	288/925 - (31%)
Similarity:	461/925 - (49%)	Gaps:	122/925 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RLPTALRPQRYYLRILTLLESPDDLRFAGNVQIVIKALQNTRNITLHSKNLTIDE-------SRI 85
            ||||.:.|:.|.|.:...|:   :..|.|...:.:...:.|..|||::.::.:|.       |::
  Fly   218 RLPTNVVPRHYELLLQPNLK---EFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVELHFECSKL 279

  Fly    86 TLRQISGAGNMDNCVSSTSVNPTHDYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYKD 150
            ...:|        ..|:.:...|.::     .:|:.|.....|.:.|:.:|..::.|:|||.|..
  Fly   280 KPEKI--------VYSAENETATLEF-----AQEIPAETQGVLHMSFTGELNDKMKGFYRSKYFG 331

  Fly   151 PVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPV----------RE 205
            | ..:.|:...||||.:.||:.|||:|||..||:|.:||...|...|||||||          |.
  Fly   332 P-NGEERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSLPDGLRR 395

  Fly   206 IRPHESLANYIWCEFQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAIDQCDYAAEFG 270
            :|            |..:..|||||||..|.::.:......:|.|.|.:......:|..:|.|..
  Fly   396 VR------------FDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGKREQGTFALEVA 448

  Fly   271 PKVLQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVI 335
            .|||.||:::|.|.|||||:|.:|:.|||||||||||||.|||:.:|..|.::||..||.:|..:
  Fly   449 TKVLPYYKDYFNIAYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTV 513

  Fly   336 AHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVS 400
            .||:|||||||||||:|||.||||||:|::|..|.|..::||:....:........|..||||.:
  Fly   514 GHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKN 578

  Fly   401 SHPISRPIQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWE 465
            ||||..|:...:||:|.||.|||.||::|:||:|.::||::||.|:..||..:.|.|....:||.
  Fly   579 SHPIEVPVGHPSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWA 643

  Fly   466 SLTTAAHQNGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRNSQI------P 524
            :|..|:.:|        ::.:|.|||...||||:::..:.::     ..:|.||..|.      .
  Fly   644 ALQEASSKN--------VSDVMTSWTQHKGFPVVSVESEQTS-----KNQRLLRLKQCKFTADGS 695

  Fly   525 QADRVGCWWVPLSYTTQDENDFNNTS-PKAWMECSSTDEGVPTTIDHSAGPEEWLILNIQLSTPY 588
            |||....|.||:|.:|..    |.|. .|.::...|:.|   .|:| :...::|:.:|......|
  Fly   696 QADENCLWVVPISVSTSK----NPTGIAKTFLLDKSSME---VTLD-NVDEDDWIKINPGTVGYY 752

  Fly   589 KANYDARNWKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIP 653
            :..|   :.::|...:.:.:...:..::|..||||:......|.......|.:.:..|.|.:...
  Fly   753 RTRY---SQEMLEQLMPAVEKMELPPLDRLGLIDDMFAMVQAGHASTADVLALVDSYRNETNYTV 814

  Fly   654 WKSALDNLKLLNRILRQTPNFGSFKRYMQKLLTPI-----YEHLHGMNDTFSLMTQQDEVLLKTT 713
            |.:..::|..|:.::..|.....|.|:.:.|..|:     :|...|.|..        :.||::.
  Fly   815 WTAITNSLTNLHILISHTDLMEDFHRFGRNLYEPVAYRLGWEPRDGENHL--------DTLLRSL 871

  Fly   714 VVNVACQYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYR 778
            |:.....:..||.:.:|:..|||   ..|..|  .:|.:||:|.|...:..|.|:.:|.:...||
  Fly   872 VLTRLVSFRSSDTIEEAKIRFRR---HVNGTE--LLPADLRTTCYKAVLQDGDEKIFNEMLDLYR 931

  Fly   779 KSNVASERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFI 843
            .:::..|:..|...|||..::.:|:|.::  |...|.:|.|||.....|||....|..:|.::|.
  Fly   932 ATDLHEEQDRISRALGCCGDLKLLRRVID--FAMSSEVRAQDSVFVIVAVAINPKGRDMAWEFFK 994

  Fly   844 E-NVELIHKYYYPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSR-----HFLK-----GIRQA 897
            | |.:|:.:  |....::|||:..|.|            :||::.|     .||:     |..:.
  Fly   995 ENNKQLLER--YQGGFLLSRLIKYLIE------------NFASEERAKEVEEFLQVNQIPGCERT 1045

  Fly   898 MQQSLETMLTNVQWM 912
            :.|::||:..|..|:
  Fly  1046 VSQAVETIRLNAAWL 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	156/414 (38%)
		M1_APN_2	43..497	CDD:189008	174/470 (37%)
		ERAP1_C	578..904	CDD:288671	80/341 (23%)
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	156/414 (38%)
		M1_APN_2	227..667	CDD:189008	176/476 (37%)
		ERAP1_C	742..1052	CDD:288671	80/341 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462109
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	8	7.850