DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31445 and CG3502

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_611781.3	Gene:	CG3502 / 37695	FlyBaseID:	FBgn0046253	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	931	Identity:	320/931 - (34%)
Similarity:	506/931 - (54%)	Gaps:	35/931 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WFLLFVLAIGLDLSVANSISRYNHYRLPTALRPQRYYLRILTLLESPDDLRFAGNVQIVIKALQN 67
            |::..:|       |.:..:.|..||||.::.|..|.|||||.|.|.|. ||.|:|.|.:.|.:.
  Fly    11 WWIFLIL-------VPSIRAVYEDYRLPRSVEPLHYNLRILTHLNSTDQ-RFEGSVTIDLLARET 67

  Fly    68 TRNITLHSKNLTIDESRITLRQISGAGNMDNCVSSTSVNPTHDYYIFHTCKELLAGNVYKLFLPF 132
            |:|||||:..|.|||:|.::  :||.....  |:...||..|::||.|..:||:...:|||.:.|
  Fly    68 TKNITLHAAYLKIDENRTSV--VSGQEKFG--VNRIEVNEVHNFYILHLGRELVKDQIYKLEMHF 128

  Fly   133 SADLTPQLFGYYRSSYKDPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNA 197
            .|.|.....|||:|:|.|.||.:...|:.|||.|:.||:||||||||.:||:|.:||||||::..
  Fly   129 KAGLNDSQSGYYKSNYTDIVTKEVHHLAVTQFSPTFARQAFPCFDEPSWKATFNITLGYHKKYMG 193

  Fly   198 LSNMPVREIRPHESLANYIWCEFQESVPMSTYLVAYSVNDF---SFKPSTLPNGALFRTWARPNA 259
            ||.|||...:.|:||.||:||:....:..||||||::|:|.   :.:.|...|..:||.|.:|..
  Fly   194 LSGMPVLRCQDHDSLTNYVWCDHDTLLRTSTYLVAFAVHDLENAATEESKTSNRVIFRNWMQPKL 258

  Fly   260 IDQCDYAAEFGPKVLQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSS 324
            :.|...:.|..||:|.:||..|.|.:||.|:||:.||.....||||||||.|.|..|..:.....
  Fly   259 LGQEMISMEIAPKLLSFYENLFQINFPLAKVDQLTVPTHRFTAMENWGLVTYNEERLPQNQGDYP 323

  Fly   325 LADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTAL 389
            ...|...|..:|||.|||||||||||.||.||||.||.:||...|.:..:.|||...::.....|
  Fly   324 QKQKDSTAFTVAHEYAHQWFGNLVTMNWWNDLWLKEGPSTYFGYLALDSLQPEWRRGERFISRDL 388

  Fly   390 MTAFRLDSLVSSHPISRPIQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYA 454
            ...|..||..:...||:.::...|:...|....|:|||..:||:|..:|||:|..|:|.:|:.::
  Fly   389 ANFFSKDSNATVPAISKDVKNPAEVLGQFTEYVYEKGSLTIRMLHKLVGEEAFFHGIRSFLERFS 453

  Fly   455 YKNAEQNNLWESLTTAAHQNGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLR 519
            :.|..|.:||.||..||.:|..:...::::..|||||||.|:|::.:.|:|.||...:.|.|:.:
  Fly   454 FGNVAQADLWNSLQMAALKNQVISSDFNLSRAMDSWTLQGGYPLVTLIRNYKTGEVTLNQSRFFQ 518

  Fly   520 NSQIPQADRVGCWWVPLSYTTQDENDFNNTSPKAWMECSSTDEGVPTTIDHSAGPEEWLILNIQL 584
            ...|.:|.  .||||||.:..|:..|||.|:|:.|:||....: |....|| ...:||:|||.|:
  Fly   519 EHGIEKAS--SCWWVPLRFVRQNLPDFNQTTPQFWLECPLNTK-VLKLPDH-LSTDEWVILNPQV 579

  Fly   585 STPYKANYDARNWKLLIDTL-NSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRE 648
            :|.::.|||..||:|:|::| |..:...||.:|:|||:||::..|......|:.|..:..||::|
  Fly   580 ATIFRVNYDEHNWRLIIESLRNDPNSGGIHKLNKAQLLDDLMALAAVRLHKYDKAFDLLEYLKKE 644

  Fly   649 RDLIPWKSALDNLKLLNRI--LRQTPNFGSFKRYMQKLLTPIYEHLHGMNDTFSLMTQQDEVLLK 711
            :|.:||:.|:.   :|||:  |........||.||||||.|:|.....::..........::...
  Fly   645 QDFLPWQRAIG---ILNRLGALLNVAEANKFKNYMQKLLLPLYNRFPKLSGIREAKPAIKDIPFA 706

  Fly   712 TTVVNVACQYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSR 776
            ....:.||:|.|:||..||:......|.|...:    :|.:.:...||:.:.:|.:.::..::..
  Fly   707 HFAYSQACRYHVADCTDQAKILAITHRTEGQLE----LPSDFQKVAYCSLLDEGGDAEFLEVFGL 767

  Fly   777 YRKSNVASERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQY 841
            ::.|...|:|:.:.|.|||.:.....::::..:......:......|..::..:||........|
  Fly   768 FQNSTNGSQRRILASALGCVRNFGNFEQFLNYTLESDEKLLGDCYMLAVKSALNREPLVSPTANY 832

  Fly   842 FIENVELIHKYYYPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRHFLKGIRQAMQQSLETML 906
            .|.:.:.:.:.:  :.:.::.||..|::.:.:..::::.::...|.:.|.:.:::|:.|.    .
  Fly   833 IISHAKKLGEKF--KKKELTGLLLSLAQNLRSTEEIDRLKAQLEDLKEFEEPLKKALYQG----K 891

  Fly   907 TNVQWMDWNYHKFSRTIRHHL 927
            .|.:|.......|...|..||
  Fly   892 MNQKWQKDCSSDFIEAIEKHL 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	171/400 (43%)
		M1_APN_2	43..497	CDD:189008	193/456 (42%)
		ERAP1_C	578..904	CDD:288671	79/328 (24%)
CG3502	NP_611781.3	Peptidase_M1	29..425	CDD:279741	171/400 (43%)
		M1_APN_2	37..496	CDD:189008	197/463 (43%)
		ERAP1_C	573..890	CDD:288671	78/325 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449978
Domainoid	1	1.000	114	1.000	Domainoid score	I6014
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm40365
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	9	8.850