DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31445 and Trhde

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_001102461.1	Gene:	Trhde / 366894	RGDID:	728895	Length:	1066	Species:	Rattus norvegicus

Alignment Length:	941	Identity:	292/941 - (31%)
Similarity:	490/941 - (52%)	Gaps:	91/941 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 YNHYRLPTALRPQRYYLRILTLLESPDDLRFAGNVQIVIKALQNTRNITLHSKNLTIDESRITLR 88
            :...||...|:|..|.|.:...:|   :..|:|.|.:.|.....||.:.||:..:.:::.::...
  Rat   178 WTQLRLSGHLKPLHYNLMLTAFME---NFTFSGEVNVEIACQNATRYVVLHASRVAVEKVQVAED 239

  Fly    89 QISGAGNMDNCVSSTSVNPTHDYYIFHTCKELL--------AGNVYKLFLPFSADLTPQLFGYYR 145
            :..||            .|...::::...:.|:        |...|.|.:.::|.:..:|.|::|
  Rat   240 RAFGA------------VPVAGFFLYPQTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFR 292

  Fly   146 SSYKDPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHE 210
            |||  .:..:.|:|..|||.|:.|||||||||||.:||:|.:::.:...:.:||||||......|
  Rat   293 SSY--VIHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEE 355

  Fly   211 SLANYIWCEFQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAI--DQCDYAAEFGPKV 273
            .  .::...|.::..||||.:|:::.:|:::.:|..:|.:.|.:|||:||  ...|||.....::
  Rat   356 D--GWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRL 418

  Fly   274 LQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHE 338
            :::||::|.:.|.|||:|.:|||.....|||||||..:.|..:|..|:.||::...|:..||.||
  Rat   419 IEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHE 483

  Fly   339 LAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLT-ALMTAFRLDSLVSSH 402
            :.|||||:|||..||.|:||.||||.|...:|...:||.|:...:..|| .|.....||.|.|||
  Rat   484 ICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPSWNMEKQRFLTDVLHEVMLLDGLASSH 548

  Fly   403 PISRPIQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESL 467
            |:|:.:...|:|::.||.|:|:||:|::||:..|||...|:.||::||.::.|.||.:|:||.:|
  Rat   549 PVSQEVLRATDIDKVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTL 613

  Fly   468 TTAAHQNGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAE----ITQERY----------- 517
            :.|..:||.   :.:|..:||.||||.|:||:.|..:.   |||    |||:.:
  Rat   614 SEALKRNGK---YVNIQEVMDQWTLQMGYPVITILGNM---TAENRILITQQHFIYDIGAKTKAL 672

  Fly   518 -LRNSQIPQADRVGCWWVPLSYTTQDENDFNNTSPKA--WMECSSTDEGVPTTIDHSAGPEEWLI 579
             |:||..       .|.:||:....:.   ::.|.:|  |:...|....: |.:|..:    |::
  Rat   673 QLQNSSY-------LWQIPLTIVVGNR---SHVSSEAIIWVSNKSEHHRI-TYLDKGS----WIL 722

  Fly   580 LNIQLSTPYKANYDARNWKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNY 644
            .||..:..::.|||.|||:||||.| .::.:.:.|.|||.||||....|..|.......|::..|
  Rat   723 GNINQTGYFRVNYDLRNWRLLIDQL-IRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRY 786

  Fly   645 LRRERDLIPWKSALDNLKLLNRILRQTPNFGSFKRYMQKLLTPIYEHLHGMNDTFS-----LMTQ 704
            |..|:|.:||.:|...|..|:::|.:..|:..|..|:.|.:...|..|....:.|:     ...|
  Rat   787 LSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYSKLGWPKNNFNGSVVQASYQ 851

  Fly   705 QDEVLLKTTVVNVACQYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEED 769
            .:|  |:..|:.:||.:....|..||......|.:    ...:.:|||:|..||||.:|...|:.
  Rat   852 HEE--LRREVIMLACSFGNKHCHQQASTLISDWIS----SNRNRIPLNVRDIVYCTGVSLLDEDV 910

  Fly   770 WNFLWSRYRKSNVASERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVG 834
            |.|:|.::..:...||::.:|..|.||.:..:|.|.:..|.: ...:..||:......||....|
  Rat   911 WEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLSRLLNLSLN-SEVVLDQDAIDVIIHVARNPHG 974

  Fly   835 FLLAKQYFIENVELIHKYYYPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRHFLKGIRQA-M 898
            ..||.::|.:..::::..|.....:.|:|::.::|.::|..:|.:.::|...    ..|:..| .
  Rat   975 RDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKS----YDGVASASF 1035

  Fly   899 QQSLETMLTNVQW----MDWNYHKFSRTIRH 925
            .:::||:..||:|    .|..:....:.:||
  Rat  1036 SRAVETVEANVRWKRLYQDELFQWLGKAMRH 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	141/408 (35%)
		M1_APN_2	43..497	CDD:189008	166/464 (36%)
		ERAP1_C	578..904	CDD:288671	90/331 (27%)
Trhde	NP_001102461.1	M1_APN-Q_like	190..635	CDD:341064	164/466 (35%)
Trhde	NP_001102461.1	ERAP1_C	720..1044	CDD:403137	93/335 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349250
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850