DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31445 and CG40470

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster

Alignment Length:	967	Identity:	253/967 - (26%)
Similarity:	444/967 - (45%)	Gaps:	103/967 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFVLAI-----GLDLSV--ANSISRYNHYRLPTALRPQRYYLRILTLLE-SPDDLRFAGNVQIVI 62
            ||:|.|     ||:..|  .:|:...:..|||..:.|..|.:    |:| ..|:..|.|::::.:
  Fly    23 LFILTILLTAPGLEAFVNDFSSLHVISEVRLPKEVLPLSYEV----LIEPHMDNQNFEGSIRMHL 83

  Fly    63 KALQNTRNITLHSKN-LTIDESRITLRQIS-GAGNMD-NCVSSTSVN-PTHDYYIFHTCKELLAG 123
            :.:.:::.:..|:.: |.||.|:|.|..:: |.|.:| |.:....|. |....::.:...::..|
  Fly    84 RWIGDSKKVYFHAHDTLLIDVSQINLTTLNMGDGTLDKNVIILRGVRLPRKPVFVLYLKDKIKKG 148

  Fly   124 NVYKLFLPFSADLTPQLFGYYRSSYKDPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVT 188
            :...|.:.|..:::....|.:||.|.:...:......||..:|::||:.||||||||.|..|.|:
  Fly   149 SECLLDIYFQGNISETEEGLFRSYYTNSGNDGEEIYLATNLKPNNARRLFPCFDEPGIKVPFNVS 213

  Fly   189 LGYHKQFNALSNMPVREIRPHESLANYIWCEFQESVPMSTYLVAYSV------NDFSF-KPSTLP 246
            :...|.:..|.|.|:.....|..|.:|....|..:.||||:...:.:      |:... |.|.:|
  Fly   214 IARPKGYITLFNTPLHNTINHPKLRSYSLDFFHTTAPMSTHAFGFVILKLHMWNEHKIVKSSDIP 278

  Fly   247 NGALFRTWAR----PNAIDQCDYAAEFGPKVLQYYEEFFGIRYPLPKIDQMAVPD------FSAG 301
               ....|:.    .|.:| ...........:|:   ||.|..||.|:|.:|:|.      .||.
  Fly   279 ---AINIWSNNLSSTNLLD-IQNKLNVAHTTIQH---FFNIPLPLTKLDVIAIPSLATLPFISAS 336

  Fly   302 AMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATYV 366
                 |::..|||.:|          |:|:.. |:.||.:||.|..:|.:||||..:|:...:::
  Fly   337 -----GILIARESEIL----------KKDVFE-ISRELIYQWIGIWITPEWWTDANVNKALISFI 385

  Fly   367 AGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHPISR--PIQMVTEIEESFDAISYQKGSAV 429
            |...|.||........|..:|.|.:.:        :.:|:  |...:|.|:..|.:|..|   .:
  Fly   386 ASEIVFEINGGIEFNGKYPMTILYSLY--------YELSKRYPNSHITGIKHEFASIKVQ---LI 439

  Fly   430 LRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQNGALPGHYDINTIMDSWTLQT 494
            :||:.|.:|:.:||.|::.::..|.:|..:.::.|.::||.|..:.:|.....|.:|.:||...:
  Fly   440 IRMLSLTVGKYTFRLGIQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSDLSILSIAESWLEHS 504

  Fly   495 GFPVLNITRDYSTGTAEITQERYLRN--SQIPQADRVGCWWVPLSYTTQDENDFNNTSPKAWMEC 557
            ..|::.|.|||.:.||.:.|:.|||.  ..:|..|.: .||:|::...||...|.||....||
  Fly   505 RLPLVTIIRDYDSETAIVQQKVYLRERLHDVPDQDNM-LWWIPIALKRQDSLSFVNTGSFKWM-- 566

  Fly   558 SSTDEGVPTTIDHSAGPEEWLILNIQLSTPYKANYDARNWKLLIDTLNSKD-FQSIHVINRAQLI 621
            :.|.:   ..|.:......::|:|.:...|:..|||..||.:|...|.::: .:||.|..||:|:
  Fly   567 NKTRQ---MLISNLPSKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLL 628

  Fly   622 DDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDNLKLLNRILRQTPNFGSFKRYMQKLLT 686
            .|....|:.||.::.|||.||.:|:.||:.|.|......|..:.:.|.::.....|:.|:.:||.
  Fly   629 HDAWNLAYAGELNFSTALNVTLFLKYERNHIVWSPVFTFLDQVGKRLEKSSINKKFELYIIELLA 693

  Fly   687 PIYEHL---HGMNDTFSLMTQQDEVLLKTTVVNVACQYDVSDCVTQAQAYFRRWRAETNPDENHP 748
            |:||:|   | .|:..::..      |:....:..|:.....|..:|:..|..|...:.|:...|
  Fly   694 PLYEYLGTAH-FNEDINITE------LRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFETP 751

  Fly   749 VPLNLRSTVYCTAISQGTEEDWNFLWSR---YRKSNVASERQTILSTL-GC----SKEVWILQRY 805
            ||    :...|:....|:.::|.|...|   :.||.:.|:|..:|..| ||    .|...:|:..
  Fly   752 VP----NEYICSIFKWGSMKEWMFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELA 812

  Fly   806 MEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIENVELIHKYYYPQTRVMSRLLTPLSEQ 870
            :.|:.   |.....|..|....|.||.:|:.....:...|.:.||..:|..|.:.::|::..:..
  Fly   813 ILKNI---SIFSDTDKMLIISTVTSRSIGYTTLLDFLSNNWDDIHHKFYNNTNIWTKLISSATGM 874

  Fly   871 VSTINDLNKFRSFANDSRHFLKGIRQAMQQSLETMLTNVQWMDWNYHKFSRTIRHHL 927
            .||....:..:.|.::........:..:::||..:...:||...|.......|.|:|
  Fly   875 FSTQEGYDLVKKFYDEHYGHFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEWIDHYL 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	110/421 (26%)
		M1_APN_2	43..497	CDD:189008	123/477 (26%)
		ERAP1_C	578..904	CDD:288671	86/337 (26%)
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	124/480 (26%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	84/335 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920