DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31445 and CG31343

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster

Alignment Length:	937	Identity:	275/937 - (29%)
Similarity:	461/937 - (49%)	Gaps:	117/937 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 HYRLPTALRPQRYYLRILTLLESPDDLRFAGNVQIVIKALQNTRNITLHSKNLTIDESRITLRQI 90
            :||||....|:.|.:.:.|.:.: .|..|.|.|.|.|:.|..|.|||||.:..:..|:.|..|.:
  Fly    55 NYRLPNTTEPESYNVELWTNVHN-GDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDV 118

  Fly    91 SGAGNMDNCVSSTSVNPT------HDYYIF--HTCKELLAGNV-YKLFLPFSADLTPQLFGYYRS 146
            :         :.|::..|      .::.:.  .|..|....|. :.:.:.::......:.|:|.|
  Fly   119 A---------TPTAIPLTVTPELQREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYIS 174

  Fly   147 SYKDPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHES 211
            ||.|. ..:..:|:.||||.::||.||||:|||..:|:|.:|:.:...:.|:|||||........
  Fly   175 SYTDD-DGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPVNTAATSSG 238

  Fly   212 LANYIWCEFQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAIDQCDYAAEFGPKVLQY 276
            :.     .||.:..|||||||:.|:||......| ||...|.::|....||.::|...|..|...
  Fly   239 VT-----AFQTTPKMSTYLVAFIVSDFESTTGEL-NGIRQRVFSRKGKQDQQEWALWSGLLVESS 297

  Fly   277 YEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAH 341
            ...:||:.:.|||:||..:|||||||||||||..|||..:.::..:|::..|.::||:|.||.||
  Fly   298 LASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAH 362

  Fly   342 QWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEW------HSRDKGSLTALMTAFRLDSLVS 400
            .|||:||::||||.|||.|||||..:.......:|.|      |..|..|  ||:.    |:|.|
  Fly   363 MWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNS--ALLN----DALAS 421

  Fly   401 SHPISRPIQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWE 465
            :.|::..:|..:||...::..||.|.::||.|......::.|||||.:||....|.:.::.:|:.
  Fly   422 AVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFA 486

  Fly   466 SLTTAAHQNG-ALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRNSQIPQADRV 529
            |...:|.:.| .||.  .::.|..||:.|.|:|:|.:||:|:.||..|||:||:.|.....:
  Fly   487 SFQESADELGFTLPA--SVDDIFSSWSHQAGYPLLTVTRNYNAGTITITQKRYVANKTDTNS--- 546

  Fly   530 GCWWVPLSYTTQDENDFNNTSPKAWMECSSTDEGVPTTI--DHSAGPEEWLILNIQLSTPYKANY 592
            ..|:|||::.|.::.|:.:||...::      ..|..|:  |..|..::|:|:|||.|..|:..|
  Fly   547 ATWYVPLNFATANKYDYRDTSATHYL------LNVTETVISDVEASSDDWIIVNIQNSGYYRTLY 605

  Fly   593 DARNWKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSA 657
            |.:|:.|:...|.|:.:: .|..|||||:.|...|..|....:...|::..||..|:...||.:|
  Fly   606 DTQNYGLITAALKSQPWR-FHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTA 669

  Fly   658 LDNLKLLNRILRQTPNFGSFKRYMQKLLTPIYEHL--------HGMNDTFSLMTQQDEVLLKTTV 714
            ...|.:.:|.||...::.:|:.::::|:.||::.:        |.:|:           .|:..:
  Fly   670 NTILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKIGVNEIPGEHYLNN-----------YLRIVL 723

  Fly   715 VNVACQYDVSDCVTQA----QAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWS 775
            |::|||....||..|:    ..|.....|         :...|::..||..:...|.|.::.:.|
  Fly   724 VSLACQVGSDDCYNQSANKLSEYLYNGTA---------IEATLKTQAYCAGLRSTTNEIYSRVQS 779

  Fly   776 RYRKSNVASERQTILSTLGCSKEVWILQRYMEKSFHPKSAIR-KQDSSLCFQAVASREVGFLLAK 839
            ....|:.:::|...:|:||||.....|..::..|....:::. .:.:||...|.:..|:|...:.
  Fly   780 DLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTASL 844

  Fly   840 QYFIENVELIHKYYYPQTRVMSRLLTPLSEQVST--INDLNKFR-------------SFANDSRH 889
            ::...|.|.     |......::.|......::|  :::..|.|             |:.||.
  Fly   845 EFLESNWEA-----YANLSDSAKPLDAALRGIATYVVSEKQKTRLNALVDVVEADGPSYINDD-- 902

  Fly   890 FLKGIRQAMQQSLETMLT-NVQWMDWN 915
                    :..::::.:| |..|::.|
  Fly   903 --------LSTTIDSRITSNFAWLEVN 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	143/412 (35%)
		M1_APN_2	43..497	CDD:189008	161/469 (34%)
		ERAP1_C	578..904	CDD:288671	78/353 (22%)
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	143/411 (35%)
		M1_APN_2	65..517	CDD:189008	162/476 (34%)
		ERAP1_C	591..886	CDD:288671	75/320 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462094
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	8	7.850