DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31445 and lnpep

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_021331684.1	Gene:	lnpep / 322814	ZFINID:	ZDB-GENE-030131-1534	Length:	1026	Species:	Danio rerio

Alignment Length:	929	Identity:	298/929 - (32%)
Similarity:	476/929 - (51%)	Gaps:	102/929 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LSVANSISRYNHYRLPTALRPQRYYLRILTLLESPD--DLRFAGNVQIVIKALQNTRNITLHSKN 77
            :|.:..:..:...|||.::.|..|.:.:     .||  .:.|.|||.||:..:..|:||.|||.:
Zfish   164 ISTSGELFPWTDLRLPVSVHPVHYNISL-----HPDLNSMTFQGNVSIVVLVMHETKNIILHSSD 223

  Fly    78 LTIDESRITLRQISGAGNMDNCVSSTSVNPTHD--YYIFHTCK----------ELLAGNVYKLFL 130
            :.|                        :..|.|  .|.|...|          |.|....|.|..
Zfish   224 MNI------------------------IKVTFDDKEYRFLEYKPWQQIAIKFPEDLKKGQYVLKF 264

  Fly   131 PFSADLTPQLFGYYRSSYKDPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQF 195
            .:.|:|:....|:|.|||.|....| |.|:||||||.:|||||||||||.||::|||.:....::
Zfish   265 SYKANLSNSYDGFYNSSYVDTAGTK-RVLAATQFEPLAARKAFPCFDEPAFKSTFVVKMTREAKY 328

  Fly   196 NALSNMPVREIRPHESLANYIW-CEFQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNA 259
            .:|||||  :|:..:...|.:. .||:.||.|||||||:.|.:||.....:....: ..:|.|:.
Zfish   329 ISLSNMP--KIKTTDLNENGLQEDEFESSVKMSTYLVAFIVAEFSSHSKNVSKTTV-SVYAVPDK 390

  Fly   260 IDQCDYAAEFGPKVLQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSS 324
            .||..||.|...|:|::|..||.|.|||.|:|.:|:|||.|||||||||:.:||:|||.. ..||
Zfish   391 KDQVHYALETACKLLKFYNTFFEIEYPLSKLDLVAIPDFLAGAMENWGLITFRETTLLVG-NQSS 454

  Fly   325 LADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTAL 389
            ..|||.:.:|||||||||||||||||:||.|||||||||||:..:.::.::|:. ..|...|...
Zfish   455 RFDKQLVTSVIAHELAHQWFGNLVTMRWWNDLWLNEGFATYMQYMSIENVFPDL-DIDIEFLNVR 518

  Fly   390 MTAFRLDSLVSSHPISRPIQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYA 454
            ..|...|:|.||||:|..:....::||.||::||:||:::|.|::..:.:..|..|:.|||:.|.
Zfish   519 FKALAKDALNSSHPVSTFVSTPEQVEEMFDSVSYEKGASILLMLNATLRDGEFHKGVIEYLQNYN 583

  Fly   455 YKNAEQNNLWESLTTAAHQNGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLR 519
            ..|.|..:||.||:..:.|:      .:::.:|::||:..|||::.:.|:....|  ::||.:|.
Zfish   584 LSNTESKDLWNSLSQVSKQS------LNVSEMMNTWTVHKGFPLVTVKRNGPQVT--LSQEHFLL 640

  Fly   520 NSQIPQADRVGCWWVPLSYTTQDENDFNNTSPKAWMECSST----DEGVPTTIDHSAGPEEWLIL 580
            |:: ...|....|.:||:|.        |.|......|...    |:.....:   .|..:||..
Zfish   641 NAE-NGTDDSSLWHIPLTYV--------NDSCSVLRSCKQVFHLKDKEATLQL---PGQVKWLKF 693

  Fly   581 NIQLSTPYKANYDARNWKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYL 645
            |.:....|..:||.:.|..||..| ..|...:...::|.||:::...:..|:..:...|.:.:|:
Zfish   694 NFRSDGFYIVHYDEQGWSDLISAL-KVDVNVLPSEDKAALINNIFALSRLGKVSFRQVLNLMDYI 757

  Fly   646 RRERDLIPWKSALDNLKLLNRIL--RQTPNFGSFKRYMQKLLTPIYEHLHGM--NDTFSLMTQQD 706
            |.|.:..|...||..|..:.|:|  |...|..|      .:.|.|..|...:  :.::.:.|...
Zfish   758 RNETETAPLTEALSQLGQIYRLLDKRSDLNLAS------SMTTYIESHFGSLMESQSWEVETSVS 816

  Fly   707 EVLLKTTVVNVACQYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWN 771
            ::.|::.::..||..:..:|.|||:..|.:|.|.   ::...:|.:|..||:  .::..|:|.|:
Zfish   817 KMTLRSALLETACALNRPNCTTQARRLFDQWLAS---NKTLQIPSDLMRTVF--KVAAKTDEGWS 876

  Fly   772 FLWSRYRKSNVASERQTILSTLGCSKEV----WILQRYMEKSFHPKSAIRKQDSSLCFQAVASRE 832
            .|...|:.|...:|::.:|..|..:::|    |:||:.::     .|.|:.|:..|....|....
Zfish   877 KLLGSYKHSIYDTEKRKMLEALASTQDVRKIIWVLQKSLD-----GSEIQNQEFPLVIHTVCRDF 936

  Fly   833 VGFLLAKQYFIENVELIHKYYYPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRHFLKGIR-Q 896
            .|:|.|..:..||.|.|.:.:...:..:..::|..:.|.||...|.:.::|.  |....||.: :
Zfish   937 AGYLYAWDFMKENWEKITQKFPIGSFAIQSIITSTTSQFSTKTHLAEVQNFF--SSLGAKGSQMR 999

  Fly   897 AMQQSLETMLTNVQWMDWN 915
            .:|:::||:..|::||:.|
Zfish  1000 IVQEAIETIKHNMRWMEKN 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	171/412 (42%)
		M1_APN_2	43..497	CDD:189008	187/468 (40%)
		ERAP1_C	578..904	CDD:288671	80/334 (24%)
lnpep	XP_021331684.1	M1_APN_2	185..620	CDD:189008	188/475 (40%)
lnpep	XP_021331684.1	ERAP1_C	690..1009	CDD:314669	83/337 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590556
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850