DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31445 and Aopep

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_008769651.1	Gene:	Aopep / 290963	RGDID:	1309592	Length:	886	Species:	Rattus norvegicus

Alignment Length:	720	Identity:	145/720 - (20%)
Similarity:	242/720 - (33%)	Gaps:	256/720 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 CKELLAGN------VYKLFLPFSADLTPQLFGYYRSSYKDPVTNKTRWLS--------ATQFEPS 167
            |.|||..:      :.|..:|.:||....:..:|::.   |......|.|        .|...|.
  Rat   279 CGELLFDSDKWSLQIRKKGVPTAADFPHAIRIWYKTK---PEGQSVTWTSDQDGRPCVYTMGSPI 340

  Fly   168 SARKAFPCFDEP----------GFKASFVVTLGYHKQFNALSNMPVREIRPHESLANYIWCEFQE 222
            :.|..|||.:.|          ...|||||.:...|   :....|:||        .|:...:..
  Rat   341 NNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGEK---SAKPTPLRE--------GYMSWHYYV 394

  Fly   223 SVPM--STYLVAYSVNDFSFKPST-------------LPNGALFRTWARPNAIDQCDYAAEFG-- 270
            ::||  ||:.:|..... ..||.|             .|:.|.||   ..|.....:|...|.
  Rat   395 TMPMPASTFTIAVGCWT-EMKPKTSPLDDLTEHTLPLRPSDADFR---YGNTCSHMEYPCRFQSA 455

  Fly   271 ------------------------------PKVLQYYEEFFGIRYPLPKIDQMAVP-DFSAGAME 304
                                          |..|.......| .:|..::|.:.|| :|.:..|.
  Rat   456 SAATQNIIPYRVFAPVCLEGACREALLWLIPSCLSAAHSVLG-THPFSRLDILIVPTNFPSLGMA 519

  Fly   305 NWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGL 369
            :..::...:|||..:   |.|...:     :.||:||.|||..:..:.||:.||:|||||::..:
  Rat   520 SPHIIFLSQSTLTGT---SHLCGTR-----LCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDI 576

  Fly   370 ---GVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHP----ISRPIQMVT--------------- 412
               ..|:: |...:.::..|.|.:...||...:.:.|    :.||.:..|
  Rat   577 FWAEAQQL-PPHEALEQQELRACLRWHRLQDELQNSPEGMQVLRPNKEKTGHVSASGASVVKNGL 640

  Fly   413 EIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQNGAL 477
            ..|:.|..:.|.||..:||.:...:|||::...||:::.|:                    :|.|
  Rat   641 NPEKGFMQVHYLKGYFLLRFLARTLGEETYFPFLRKFVHLF--------------------HGQL 685

  Fly   478 PGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRN--SQIPQADRVGCWWVPLSYTT 540
                                              |..:.:|:.  ..||:..|.|     ||.
  Rat   686 ----------------------------------ILSQDFLQMLLESIPENKRFG-----LSV-- 709

  Fly   541 QDENDFNNTSPKAWMECSSTDEGVPTTIDHSAGPEEWLILNIQLSTPYKANYDARNWKLLIDTLN 605
              ||...:     |:||    .|:|..:......::        .:|.:          |:..:.
  Rat   710 --ENIVGD-----WLEC----PGIPKALQEERKAKD--------CSPSR----------LVRQVG 745

  Fly   606 SKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDNLKLLNRILRQ 670
            |:..:.|.|..|            .|::.           ||:|:....|.:.|.:.||...|.:
  Rat   746 SEVAKWIRVNRR------------PGKRQ-----------RRKREAAFEKLSPDQIVLLLEWLLE 787

  Fly   671 TPNFGSFKRYMQKLLTPIYEHLHGMNDTFSLMTQQDEVLLKTTVVNVACQYDVSDCVTQAQAYFR 735
                       ||.|:|  :.||.:..|:.|..|..||..:.      |:..:....|:|....:
  Rat   788 -----------QKTLSP--QTLHRLQQTYHLQEQDAEVRHRW------CELVIKHKYTKAYDQVK 833

  Fly   736 RWRAE 740
            |:..|
  Rat   834 RFLQE 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	87/402 (22%)
		M1_APN_2	43..497	CDD:189008	99/473 (21%)
		ERAP1_C	578..904	CDD:288671	31/163 (19%)
Aopep	XP_008769651.1	GluZincin	250..697	CDD:301352	101/499 (20%)
Aopep	XP_008769651.1	Leuk-A4-hydro_C	743..884	CDD:286244	29/138 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349306
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740