DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG31445 and ANPEP

DIOPT Version :9

Sequence 1:NP_001263064.1 Gene:CG31445 / 326140 FlyBaseID:FBgn0051445 Length:927 Species:Drosophila melanogaster
Sequence 2:NP_001141.2 Gene:ANPEP / 290 HGNCID:500 Length:967 Species:Homo sapiens


Alignment Length:931 Identity:339/931 - (36%)
Similarity:506/931 - (54%) Gaps:63/931 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 AIGLDLSVANSISRYNHYRLPTALRPQRYYLRILTLLESPDD---LRFAGNVQIVIKALQNTRNI 71
            |..||.|.|     :|.||||..|:|..|.:.:...| :|:|   ..|.|:..:.....:.|..|
Human    62 ATTLDQSKA-----WNRYRLPNTLKPDSYRVTLRPYL-TPNDRGLYVFKGSSTVRFTCKEATDVI 120

  Fly    72 TLHSK--NLTIDES-RITLRQISGAGNMDNCVSSTS-VNPTHDYYIFHTCKELLAGNVYKLFLPF 132
            .:|||  |.|:.:. |:.||.:.|:...|  :..|. |.|| :|.:.|....|:..:.|::...|
Human   121 IIHSKKLNYTLSQGHRVVLRGVGGSQPPD--IDKTELVEPT-EYLVVHLKGSLVKDSQYEMDSEF 182

  Fly   133 SADLTPQLFGYYRSSYKDPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNA 197
            ..:|...|.|:|||.|.:  .|..:.::.||.:.:.|||:|||||||..||.|.:||.:.|...|
Human   183 EGELADDLAGFYRSEYME--GNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTA 245

  Fly   198 LSNM-PVREIRPHESLANYIWCEFQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAI- 260
            |||| |.....|.....|:...||..:..|||||:|:.|::|.:......||.|.|.||||:|| 
Human   246 LSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIA 310

  Fly   261 -DQCDYAAEFGPKVLQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSS 324
             ...|||......:|.::...:...|||||.||:.:|||:||||||||||.|||::||:.|..||
Human   311 AGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSS 375

  Fly   325 LADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTAL 389
            .::|:.:..||||||||||||||||::||.|||||||||:||..||.....|.|:.:|...|..:
Human   376 SSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDV 440

  Fly   390 MTAFRLDSLVSSHPISRP---IQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLK 451
            .....:|:|.||||:|.|   |....:|.|.||||||.||::||||:..|:.|:.|:.||..||.
Human   441 YRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLH 505

  Fly   452 LYAYKNAEQNNLWESLTTAAHQNGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQER 516
            .:||:|....|||:.|..|.: |.::.....:..||:.||||.||||  ||.|.||||  ::||.
Human   506 TFAYQNTIYLNLWDHLQEAVN-NRSIQLPTTVRDIMNRWTLQMGFPV--ITVDTSTGT--LSQEH 565

  Fly   517 YL--RNSQIPQADRVG-CWWVPLSYTT--QDENDFNNTSPKAWMECSSTDEGVPTTIDHSAGPEE 576
            :|  .:|.:.:..... .|.||::...  :.:.|:       |:    .|......:..::| .|
Human   566 FLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDY-------WL----IDVRAQNDLFSTSG-NE 618

  Fly   577 WLILNIQLSTPYKANYDARNWKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQV 641
            |::||:.::..|:.|||..||: .|.|...:|..:|.||||||:|:|....|...:.....||..
Human   619 WVLLNLNVTGYYRVNYDEENWR-KIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNN 682

  Fly   642 TNYLRRERDLIPWKSALDNLKLLNRILRQTPNFGSFKRYMQKLLTPIYEHLHGMNDTF-----SL 701
            |.:|..||..:||::||.:|.....:..::..:|..|.|::|.:||::.|.....:.:     :|
Human   683 TLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENL 747

  Fly   702 MTQQDEVLLKTTVVNVACQYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGT 766
            |.|..||    ..::.||...|.:|.......|::|....|   |:|:..||||||||.||:||.
Human   748 MDQYSEV----NAISTACSNGVPECEEMVSGLFKQWMENPN---NNPIHPNLRSTVYCNAIAQGG 805

  Fly   767 EEDWNFLWSRYRKSNVASERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASR 831
            ||:|:|.|.::|.:.:.:|...:.:.|.||||:|||.||:..:.:| ..|||||::....::.:.
Human   806 EEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNP-DLIRKQDATSTIISITNN 869

  Fly   832 EVGFLLAKQYFIENVELIHKYYYPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRH--FLKGI 894
            .:|..|...:...|.:.:...|...:...|.|:..::.:.||..:|.:...|..|:..  |..|.
Human   870 VIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGT 934

  Fly   895 RQAMQQSLETMLTNVQWMDWN 915
            | |::|:||....|::|:..|
Human   935 R-ALEQALEKTKANIKWVKEN 954

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31445NP_001263064.1 Peptidase_M1 28..426 CDD:279741 171/410 (42%)
M1_APN_2 43..497 CDD:189008 194/466 (42%)
ERAP1_C 578..904 CDD:288671 105/332 (32%)
ANPEPNP_001141.2 Cytosolic Ser/Thr-rich junction 33..68 3/5 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 40..62 339/931 (36%)
Metalloprotease 69..967 335/924 (36%)
M1_APN-Q_like 84..545 CDD:341064 191/467 (41%)
Necessary and sufficient to mediate interaction with HCoV-229E. /evidence=ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485 288..295 0/6 (0%)
Substrate binding. /evidence=ECO:0000269|PubMed:22932899 352..356 3/3 (100%)
ERAP1_C 619..946 CDD:403137 107/336 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155434
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S2057
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 1 1.000 - - otm40365
orthoMCL 1 0.900 - - OOG6_100307
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X67
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.700

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