DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31445 and Trhde

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_666353.2	Gene:	Trhde / 237553	MGIID:	2384311	Length:	1066	Species:	Mus musculus

Alignment Length:	941	Identity:	293/941 - (31%)
Similarity:	489/941 - (51%)	Gaps:	91/941 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 YNHYRLPTALRPQRYYLRILTLLESPDDLRFAGNVQIVIKALQNTRNITLHSKNLTIDESRITLR 88
            :...||...|:|..|.|.:...:|   :..|:|.|.:.|.....||.:.||:..:.:::.::...
Mouse   178 WTQLRLSGHLKPLHYNLMLTAFME---NFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQVAED 239

  Fly    89 QISGAGNMDNCVSSTSVNPTHDYYIFHTCKELL--------AGNVYKLFLPFSADLTPQLFGYYR 145
            :..||            .|...::::...:.|:        |...|.|.:.::|.:..:|.|::|
Mouse   240 RAFGA------------VPVAGFFLYPQTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFR 292

  Fly   146 SSYKDPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHE 210
            |||  .:..:.|:|..|||.|:.|||||||||||.:||:|.:::.:...:.:||||||......|
Mouse   293 SSY--VIHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEE 355

  Fly   211 SLANYIWCEFQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAI--DQCDYAAEFGPKV 273
            .  .::...|.::..||||.:|:::.:|:::.:|..:|.:.|.:|||:||  ...|||.....::
Mouse   356 D--GWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRL 418

  Fly   274 LQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHE 338
            :::||::|.:.|.|||:|.:|||.....|||||||..:.|..:|..|:.||::...|:..||.||
Mouse   419 IEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHE 483

  Fly   339 LAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLT-ALMTAFRLDSLVSSH 402
            :.|||||:|||..||.|:||.||||.|...:|...:||.|:...:..|| .|.....||.|.|||
Mouse   484 ICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPAWNMEKQRFLTDVLHEVMLLDGLASSH 548

  Fly   403 PISRPIQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESL 467
            |:|:.:...|:|:..||.|:|:||:|::||:..|||...|:.||::||.::.|.||.:|:||.:|
Mouse   549 PVSQEVLRATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTL 613

  Fly   468 TTAAHQNGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAE----ITQERY----------- 517
            :.|..:||.   :.:|..:||.||||.|:||:.|   ....|||    |||:.:
Mouse   614 SEALRRNGK---YVNIQEVMDQWTLQMGYPVITI---LGNTTAENRILITQQHFIYDIGAKTKAL 672

  Fly   518 -LRNSQIPQADRVGCWWVPLSYTTQDENDFNNTSPKA--WMECSSTDEGVPTTIDHSAGPEEWLI 579
             |:||..       .|.:||:....:.   ::.|.:|  |:...|....: ..:|..:    |::
Mouse   673 QLQNSSY-------LWQIPLTIVVGNR---SHVSSEAIIWVSNKSEHHRI-AYLDRGS----WIL 722

  Fly   580 LNIQLSTPYKANYDARNWKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNY 644
            .||..:..::.|||.|||:||||.| .::.:.:.|.|||.||||....|..|.......|::..|
Mouse   723 GNINQTGYFRVNYDLRNWRLLIDQL-IRNHEVLSVSNRAALIDDAFSLARAGYLPQNIPLEIIRY 786

  Fly   645 LRRERDLIPWKSALDNLKLLNRILRQTPNFGSFKRYMQKLLTPIYEHLHGMNDTF--SLMT---Q 704
            |..|:|.:||.:|...|..|:::|.:..|:..|..|:.|.:...|..|....:.|  ||:.   |
Mouse   787 LSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPRNNFNGSLVQASYQ 851

  Fly   705 QDEVLLKTTVVNVACQYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEED 769
            .:|  |:..|:.:||.:....|..||......|.:    ...:.:|||:|..||||.:|...|:.
Mouse   852 HEE--LRREVIMLACSFGNKHCHQQASTLISDWIS----SNRNRIPLNVRDIVYCTGVSLLDEDV 910

  Fly   770 WNFLWSRYRKSNVASERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVG 834
            |.|:|.::..:...||::.:|..|.||.:..:|.|.:..|.: ...:..||:......||....|
Mouse   911 WEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLSRLLNLSLN-SEVVLDQDAIDVIIHVARNPHG 974

  Fly   835 FLLAKQYFIENVELIHKYYYPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRHFLKGIRQA-M 898
            ..||.::|.:..::::..|.....:.|:|::.::|.::|..:|.:.::|...    ..|:..| .
Mouse   975 RDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKS----YDGVASASF 1035

  Fly   899 QQSLETMLTNVQW----MDWNYHKFSRTIRH 925
            .:::||:..||:|    .|..:....:.:||
Mouse  1036 SRAVETVEANVRWKRFYQDELFQWLGKAMRH 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	141/408 (35%)
		M1_APN_2	43..497	CDD:189008	166/464 (36%)
		ERAP1_C	578..904	CDD:288671	92/331 (28%)
Trhde	NP_666353.2	M1_APN-Q_like	190..635	CDD:341064	164/466 (35%)
Trhde	NP_666353.2	ERAP1_C	720..1044	CDD:378732	95/335 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845831
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950