DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31445 and LVRN

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_776161.3	Gene:	LVRN / 206338	HGNCID:	26904	Length:	990	Species:	Homo sapiens

Alignment Length:	920	Identity:	293/920 - (31%)
Similarity:	446/920 - (48%)	Gaps:	93/920 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DLSVANSISR------YNHYRLPTALRPQRYYLRILTLLESPDD-----LRFAGNVQIVIKALQN 67
            :|:|..:.|.      ::..|||..|.|..|.|.:...|. ||:     |.|.|.|.|.::....
Human    77 ELAVTTTPSNWRPPGPWDQLRLPPWLVPLHYDLELWPQLR-PDELPAGSLPFTGRVNITVRCTVA 140

  Fly    68 TRNITLHSKNLTIDESRITLRQISGAGNMDNCVSSTSVNPT-----HDYYIFHTCKELLAGNVYK 127
            |..:.|||  |..|..|..:|.....|..:..|....|:..     .:|.:....:.|..|:.|:
Human   141 TSRLLLHS--LFQDCERAEVRGPLSPGTGNATVGRVPVDDVWFALDTEYMVLELSEPLKPGSSYE 203

  Fly   128 LFLPFSADLTPQL-FGYYRSSYKDPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGY 191
            |.|.||..:...| .|.:.:.|.|  ..:.|.|.|:|.||:.||..|||||||..||:|.:|:.:
Human   204 LQLSFSGLVKEDLREGLFLNVYTD--QGERRALLASQLEPTFARYVFPCFDEPALKATFNITMIH 266

  Fly   192 HKQFNALSNMPVREIRPHESLANYIW--CEFQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTW 254
            |..:.||||||.......|.:....|  ..|..:..|.|||||:.:.|:.....| ..|...|.|
Human   267 HPSYVALSNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNRT-ERGKEIRIW 330

  Fly   255 ARPNAI--DQCDYAAEFGPKVLQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLL 317
            ||.:||  ...|:|......:..:.|:.|.|.|.|||.|.:|:|.|...|||||||:.:.||.||
Human   331 ARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGLMIFDESGLL 395

  Fly   318 YSPTHSSLADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRD 382
            ..|.......|..::.|::||:.||||||||||.||.::|||||||:|.....:....|:....:
Human   396 LEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFEVINYFNPKLPRNE 460

  Fly   383 KGSLTALMTAFRLDSLVSSHPISRPIQ--MVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTG 445
            ......|....|.|..:.:..::..::  ..:||:|.||..:|.||:::.||:..|:.|..|.:.
Human   461 IFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKGASMARMLSCFLNEHLFVSA 525

  Fly   446 LREYLKLYAYKNAEQNNLWESLTTAAHQNGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTA 510
            |:.|||.::|.||||::||.....|......:.....|..||||||.|:||||  ||.:.|||.
Human   526 LKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNIMDSWTHQSGFPV--ITLNVSTGV- 587

  Fly   511 EITQER-YLRN----SQIPQADRVGCWWVPLSYTTQDENDFNNTSPKAWMECSST--DEGVPTTI 568
             :.||. ||.|    :.:...|   .|.||:.:...     ..|.|..|::.||.  .|...:..
Human   588 -MKQEPFYLENIKNRTLLTSND---TWIVPILWIKN-----GTTQPLVWLDQSSKVFPEMQVSDS 643

  Fly   569 DHSAGPEEWLILNIQLSTPYKANYDARNWKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQ 633
            ||     :|:|||:.::..|:.|||...||.|...| .||.::|.||:|.|||||....:.....
Human   644 DH-----DWVILNLNMTGYYRVNYDKLGWKKLNQQL-EKDPKAIPVIHRLQLIDDAFSLSKNNYI 702

  Fly   634 DYETALQVTNYLRRERDLIPWKSALDNLKLLNRILRQTPN----FGSFKRYMQKLL--------T 686
            :.||||::|.||..|.::|.|.:.|.|  |:.|.|....|    :...|||:.|.|        |
Human   703 EIETALELTKYLAEEDEIIVWHTVLVN--LVTRDLVSEVNIYDIYSLLKRYLLKRLNLIWNIYST 765

  Fly   687 PIYEHLHGMNDTFSLMTQQDEVLLKTTVVNVACQYDVSDCVTQAQAYFRRWRAETNPDENHP--- 748
            .|.|::..:.|.:..:...:::.:      .||...:.||:..::..|.:|       .:||
Human   766 IIRENVLALQDDYLALISLEKLFV------TACWLGLEDCLQLSKELFAKW-------VDHPENE 817

  Fly   749 VPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNVASERQTILSTLGCSKEVWILQRYMEKSFHPK 813
            :|..::..|.|..|:.|::::|:.|.:.|..:....|:..:...:.|||:.|||.||||.:. ..
Human   818 IPYPIKDVVLCYGIALGSDKEWDILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAI-ST 881

  Fly   814 SAIRKQDSSLCFQAVASREVGFLLAKQYFIENVELIHKYYYPQTRVMSRLLTPLSEQVST---IN 875
            |.....:::: .:.|||.|||..:||.:.:.|.:.:.|.|..|:.:  .|:..:...|:|   |.
Human   882 SPFTSNETNI-IEVVASSEVGRYVAKDFLVNNWQAVSKRYGTQSLI--NLIYTIGRTVTTDLQIV 943

  Fly   876 DLNKFRSFAN 885
            :|.:|  |:|
Human   944 ELQQF--FSN 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	141/414 (34%)
		M1_APN_2	43..497	CDD:189008	162/470 (34%)
		ERAP1_C	578..904	CDD:288671	95/326 (29%)
LVRN	NP_776161.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..91		3/13 (23%)
		Peptidase_M1	97..506	CDD:279741	141/414 (34%)
		M1_APN_2	105..577	CDD:189008	164/477 (34%)
		Substrate binding. /evidence=ECO:0000250	379..383		2/3 (67%)
		ERAP1_C	648..951	CDD:288671	94/324 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155411
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750