DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31445 and Npepps

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_032968.2	Gene:	Npepps / 19155	MGIID:	1101358	Length:	920	Species:	Mus musculus

Alignment Length:	909	Identity:	267/909 - (29%)
Similarity:	441/909 - (48%)	Gaps:	87/909 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RLPTALRPQRYYLRILTLLESPD--DLRFAGNVQIVIKALQNTRNITLHSKNLTIDESRITLRQI 90
            |||..:.|..|     :|...||  |..|.|.::...:..|.|..|.::..::.|    ||   .
Mouse    54 RLPAEVSPINY-----SLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDI----IT---A 106

  Fly    91 SGAGNMDNCVSSTSVN-PTHDYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYKDPVTN 154
            |.|...|..:.:|..| ...|..:..:....|......|.:.|..:|..::.|:|||.|..| ..
Mouse   107 SYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSRYTTP-AG 170

  Fly   155 KTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLANYIWCE 219
            :.|:.:.||||.:.||:||||:|||..||:|.::|...|...|||||.|.:.:|:....|.:..:
Mouse   171 EVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVK 235

  Fly   220 FQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAIDQCDYAAEFGPKVLQYYEEFFGIR 284
            |..:..|||||||:.|.::.|..:...:|...|.:......:|..:|.|...|.|.:|:::|.:.
Mouse   236 FARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVP 300

  Fly   285 YPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVT 349
            |||||||.:|:.||:||||||||||.|||:.||..|.:|..:.:|.:|.|:.|||||||||||||
Mouse   301 YPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVT 365

  Fly   350 MKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHPISRPIQMVTEI 414
            |:|||.||||||||:::..|.|...:||:....:........|..||:|.:||||...:...:|:
Mouse   366 MEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEV 430

  Fly   415 EESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQNGALPG 479
            :|.||||||.||::|:||:|.::|::.|:.|:..||..:..|||...:|||||.:|:.:
Mouse   431 DEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLESASGK------ 489

  Fly   480 HYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRNSQ-------------IPQADRVGC 531
              .|..:|::||.|.|||::.:..:      ::..:|.|:.||             .||
Mouse   490 --PIAAVMNTWTKQMGFPLIYVEAE------QVEDDRVLKLSQKKFCASGPYGGEDCPQ------ 540

  Fly   532 WWVPLSYTTQDENDFNNTSPKAWMECSSTDEGVPTTIDHSAGPEEWLILNIQLSTPYKANYDARN 596
            |.||::.:|.:  |.|....|..|     |:...:.:..:..|::|:.||:.....|:..|.:..
Mouse   541 WMVPITISTSE--DPNQAKLKILM-----DKPEMSVVLKNVKPDQWVKLNLGTVGFYRTQYSSAM 598

  Fly   597 WKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDNL 661
            .:.|:..:  :|. |:..::|..|.:|:...|..|.......|:|......|.:...|.....||
Mouse   599 LESLLPGI--RDL-SLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNL 660

  Fly   662 KLLNRILRQTPNFGSFKRYMQKLLTPIYEHL-------HGMNDTFSLMTQQDEVLLKTTVVNVAC 719
            .:|:.:|..|..:...:.:::.:.:||.|.|       .|..|          .||:..|:....
Mouse   661 GILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLD----------ALLRGLVLGKLG 715

  Fly   720 QYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNVAS 784
            :......:.:|:..|:.     :.:....:..:|||.||.|.:..|.....:.:...::::::..
Mouse   716 KAGHKATLEEARRRFKE-----HVEGKQILSADLRSPVYLTVLKHGDGATLDIMLKLHKQADMQE 775

  Fly   785 ERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVA-SREVGFLLAKQYFIENVEL 848
            |:..|...||.:....::|:.:  :|.....:|.||:......|| ..:.|...|.::..:|.|.
Mouse   776 EKNRIERVLGATLSPELIQKVL--TFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEE 838

  Fly   849 IHKYYYPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRHFLKGIRQAMQQSLETMLTNVQWM 912
            :|..|.... ::|||:....|..:......:.::|...  |......:.:||..|.:|.|..|:
Mouse   839 LHNRYQGGF-LISRLIKLSVEGFAVDKMAGEVKAFFES--HPAPSAERTIQQCCENILLNAAWL 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	154/400 (39%)
		M1_APN_2	43..497	CDD:189008	175/456 (38%)
		ERAP1_C	578..904	CDD:288671	64/333 (19%)
Npepps	NP_032968.2	Peptidase_M1	54..442	CDD:279741	154/400 (39%)
		M1_APN_2	62..505	CDD:189008	176/463 (38%)
		Substrate binding. /evidence=ECO:0000250	317..321		3/3 (100%)
		ERAP1_C	580..891	CDD:288671	64/333 (19%)
		Nuclear localization signal. /evidence=ECO:0000255	727..731		0/3 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820