DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31445 and R03G8.6

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_510175.1	Gene:	R03G8.6 / 181438	WormBaseID:	WBGene00011000	Length:	747	Species:	Caenorhabditis elegans

Alignment Length:	752	Identity:	209/752 - (27%)
Similarity:	331/752 - (44%)	Gaps:	129/752 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFVLAI------GLDLSVANSISRYNHYRLPTALRPQRYYLRILTLL------ESPDDLRFAGN 57
            |:|:|||      .||..:|:..|    ||||..:.|..|.:.|.|.|      ...:.:.|.||
Worm     6 LVFILAIIKPFASELDARIADVAS----YRLPRHVSPSHYDIHIKTYLPGYGWKADENKITFEGN 66

  Fly    58 VQIVIKALQNTRNITLHSKNLTI-------DESRITLRQISGAGNMDNCVSSTSVNPTHDYYIFH 115
            |.|::...:.|..:.|||.:|.|       ||..::             :|..:|.....:..|:
Worm    67 VNILLDIKETTDKLVLHSSSLNIISATFQSDEQNVS-------------ISHWNVQTESQFLTFY 118

  Fly   116 TCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYKDPVTNKTR------WLSATQFEPSSARKAFP 174
            ....:...:...:.:.|...:.....|.:       .||.||      ...|||||...||...|
Worm   119 LNNTVKVQSSAGIQINFQGKVRTDGLGLF-------ATNSTREDGTVMTNFATQFETIFARNMIP 176

  Fly   175 CFDEPGFKASFVVTLGYHKQFNALSN-MPVREIRPHESLANYIW--CEFQESVPMSTYLVAYSVN 236
            |||||.|||::.|:|.:.....|||| :.|      ||..|..|  ..:::::.||:|::|..:.
Worm   177 CFDEPEFKATWNVSLEHPTGSTALSNGIEV------ESKVNDDWKTTTYKKTLKMSSYILALFIG 235

  Fly   237 DFSFKPSTLPNGALFRTWARPNAIDQCDYAAEFGPKVLQYYEEFFGIRYPLPKIDQMAVPDFSAG 301
            |..||.:.|.||...|.:..|..||:.|:|......||:.:|..||||||:.|:|.::|.:|..|
Worm   236 DIQFKETILNNGVRIRVYTDPVNIDRVDHALNISRIVLEGFERQFGIRYPMEKLDFVSVQNFKFG 300

  Fly   302 AMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATYV 366
            ||||||||.:.        .:|.:.|..|:..::.||:||||||||||||:|..:|||||||:|:
Worm   301 AMENWGLVIHN--------AYSLIGDPMDVTEIVIHEIAHQWFGNLVTMKYWDHIWLNEGFASYM 357

  Fly   367 AGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHPISRPIQMVTEIEESFDAISYQKGSAVLR 431
            ...|:..:.|: :.||...|.........|..||.: ..:.:..|.    :..|..|.||.:.:|
Worm   358 TSYGLTFLDPD-YQRDTFYLNCQFNPQINDGGVSLN-FGKNLSSVM----NNAATVYMKGCSFVR 416

  Fly   432 MMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQNGALPGHYDINTIMDSWTLQTGF 496
            |:....|.|.|...::.||:...|.|.:.|:|:|:..|::.........:||......||.|.||
Worm   417 MLENIFGTEYFNEAIKFYLEKNQYDNVDDNDLYEAFRTSSETLDTNGKPFDIEKFARCWTHQNGF 481

  Fly   497 PVLNITRDYSTGTAEITQERYLRNSQIPQADRVGC---WWVPLSYTTQDENDFNNTSPKAWMECS 558
            |.:.::.|  .|.|.:||.....    ||.....|   |.:|:.|....|....    .||:..:
Worm   482 PTIQVSND--NGIATLTQSHLYE----PQLMLNECDYKWDIPIWYQEPGEARVQ----MAWLNRN 536

  Fly   559 STDEGVPTTIDHSAGPEEWLILNIQLSTPYKANYDARNWKLLID--TLNSKDFQSIHVINRAQLI 621
            ||  .:....|.|      :|:|......|:..|..:.::.:.:  .:|...: |::.:.|.  :
Worm   537 ST--SLELVADDS------VIINANSIGYYEVLYSDKMYEKIAEQVAINVSRY-SVNSLRRT--L 590

  Fly   622 DDVLYFAWTGEQDYETALQVTNYL-RRERDLIPWKSAL---------DNLKLLNR--------IL 668
            .||..::..|...:..|..:...| ..|.:::..:|.|         :|..::|.        ::
Worm   591 HDVFRYSRDGLTPFHNAFIIAYVLVFGENEILRHESVLYLVDAVYNTNNKSIVNSKDIETVKGLV 655

  Fly   669 RQTPNFGSFKRYMQKLLTPIYEHLHGMNDTFSLMTQQ 705
            .|..||..|.:.:|             :.|||...|:
Worm   656 NQIENFELFPKCVQ-------------SQTFSSCYQK 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	132/419 (32%)
		M1_APN_2	43..497	CDD:189008	147/475 (31%)
		ERAP1_C	578..904	CDD:288671	26/148 (18%)
R03G8.6	NP_510175.1	Peptidase_M1	31..389	CDD:279741	127/392 (32%)
		M1_APN_2	39..482	CDD:189008	149/482 (31%)
		ERAP1_C	548..>622	CDD:288671	13/76 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164035
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850