DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31445 and AC3.5

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_001256214.1	Gene:	AC3.5 / 179447	WormBaseID:	WBGene00007071	Length:	1090	Species:	Caenorhabditis elegans

Alignment Length:	955	Identity:	209/955 - (21%)
Similarity:	366/955 - (38%)	Gaps:	191/955 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DLRFAGNVQIVIKALQNTRNITLHSKNLTIDESRITLRQISGAGN--MDNCVSSTSVNPTHDYYI 113
            |:.|..|    ::.:|.::.:|..:|......:..|.....|:|.  |....::|:...|.....
Worm   201 DIEFTRN----LEKIQLSKEVTKRAKKSVDSGTNSTSEMPEGSGEEAMATTATTTTTESTTPVSS 261

  Fly   114 FHTC---------------------KELLAGNVYKLFLPFSADLTPQLFGYYRSSYKDPVTNKTR 157
            |...                     :||..|:...|.:||::.::.. .|.....||:. ..|.:
Worm   262 FVDTGIKVTNIEFDENLEKVTLTLDQELKKGSTVVLKIPFTSKVSNN-NGLKEYKYKNS-EGKEQ 324

  Fly   158 WLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLANYIWCEFQE 222
            .:..||...|..|..||.||:..|||...:||.:.|....::|..|:.....::..:.:......
Worm   325 SMFTTQPSYSYLRHVFPSFDQEAFKAPAAITLMHSKGSIVVANTGVKTKDDGDAQTSTLNKVLDP 389

  Fly   223 SVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAIDQCDYAAEFGPKVLQYYEEFFGIRYPL 287
            ...:.. |||..||..|        |...|.|.||......:.:.::..:.:...|.....|...
Worm   390 DFVIGD-LVASEVNTTS--------GITIRIWTRPEVKHSTEQSLDYANQAIDAMEHILQSRLES 445

  Fly   288 PKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVTMKW 352
            ..:|.:|||.|..|...:...:...|..:||:...:.:..|..:|.:|::.:|.||||.:...:.
Worm   446 KSLDIVAVPGFQTGNRVSPSFIVLPEEDILYNEQSNDINQKTRIARMISNRIAAQWFGGITNPEE 510

  Fly   353 WTDLWLNEGFATYVAGLGVQEIYPEWHSRD----------KGSLTALMTAFRLDSLVSSHPISRP 407
            :...||||....::....:::|. :.:|.|          :...||.....|:.::.||..|:
Worm   511 FGTFWLNEALPRFLEVEALEKIL-DINSDDLWTYEMEKILERDATATSQPLRVKNVFSSADIA-- 572

  Fly   408 IQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAH 472
                 ||:..|..   :||:|||||:...:|...|...:|.::..|.......:.||:|...|.
Worm   573 -----EIDHEFIG---KKGAAVLRMIQKSVGVNVFNKAIRSFVSSYRSAYPYDDGLWKSFEKAL- 628

  Fly   473 QNGALPG----HYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRNSQIPQADRVGCWW 533
             .|.|.|    ..|:...:::|..|.|||::::.: ....|.|::|||:..:
Worm   629 -GGKLKGWNNEPLDVAKFVNTWVDQIGFPLVSVEK-LDDETVELSQERFKND------------- 678

  Fly   534 VPLSYTTQDENDFNNTSPKAWMECSSTDEGVPTTIDHSAGP---EEWL--------------ILN 581
                :.|:::..|.|.  |.|....     ||..: .|:||   ..||              .||
Worm   679 ----HKTKEQFKFRNA--KYWFNWE-----VPLFL-KSSGPVGNVSWLHEAFRLPLNTSDSIYLN 731

  Fly   582 IQLSTPYKANYDARNWKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLR 646
            ...:..|:.||:.:.|..:...| .|....:....||:||.||...|.:|...:||||.||:||.
Worm   732 TDSNGVYRVNYEEKRWNDIAKQL-EKSHGKLSERTRARLISDVFALANSGALPFETALNVTSYLP 795

  Fly   647 RERDLIPWKSALDNLKLLNRILRQTPNFGSFKRYMQKLLTPIYEHLHGMNDTFS----------- 700
            .|...:||..|....|.|...|...|       ...||.:.||:.:|...:..|
Worm   796 METATVPWLIATRIFKKLTERLEGAP-------IQDKLNSFIYQKIHKKFEEISSSPGEASSNYL 853

  Fly   701 ----------LMT-----QQDEVLLKTTVVN--VACQYD---VSDCVTQAQAYFRRWRAETNPDE 745
                      ||.     :.:|.|.:..|..  ..||:.   .|||
Worm   854 KNRLYANLLDLMAIVKPEKSNEKLNELFVEGFLAPCQFSGNFSSDC------------------- 899

  Fly   746 NHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNVASERQTILSTLGCSKEVWILQRYMEKSF 810
             ..||.:||..|||..:..|.:..:..:.....|....:|:..:.::|.|.::...|:|.:..:.
Worm   900 -SEVPGDLREKVYCNGVEFGNDTVFETVRELAEKEVDGAEKDLLQNSLACFRDPRALRRLILDNL 963

  Fly   811 HPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIENVELIHKYYY---PQTRVMSRLLTPLSEQVS 872
            :..|.:     :|..:.:.||.||..:|..:.|:|...:.|..:   |:|      |..:::...
Worm   964 NSTSTV-----TLLLRKMNSRPVGKEIATNWIIDNWSTVLKKKFKNDPET------LNAIADAGI 1017

  Fly   873 TIND------LNKFRSFANDSRHFLKGIRQAMQQSLETMLTNVQW 911
            .:::      :..|....:.|.|   || :::.:.:|...|::.|
Worm  1018 ILDNEREKSMIETFMEHHHKSTH---GI-ESLDKKIEEATTDIYW 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	85/407 (21%)
		M1_APN_2	43..497	CDD:189008	107/482 (22%)
		ERAP1_C	578..904	CDD:288671	81/379 (21%)
AC3.5	NP_001256214.1	Peptidase_M1	156..574	CDD:279741	82/395 (21%)
		GluZincin	165..656	CDD:301352	107/482 (22%)
		ERAP1_C	728..1052	CDD:288671	81/366 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	110	1.000	Domainoid score	I3949
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020