DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31445 and T16G12.1

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_499230.2	Gene:	T16G12.1 / 176416	WormBaseID:	WBGene00011803	Length:	1890	Species:	Caenorhabditis elegans

Alignment Length:	990	Identity:	249/990 - (25%)
Similarity:	414/990 - (41%)	Gaps:	200/990 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 YNHYRLPTALR-----PQRYYLRILTLLESPDDLRFAGNVQIVIKALQNTRNITLHSKNLTIDES 83
            :.:|:|...:.     |.::|          :::.|:....:..:.:..|.:||:::..|..|..
Worm  1002 FPYYKLDLQVNIPGSGPYQWY----------ENMTFSATSTVTFQLVSPTSSITINAHRLMFDPV 1056

  Fly    84 RITLRQ-----------ISGAGNMDNCVSSTSVNPTHDYYIFHTCKELLAGNVYKLFLPFSADLT 137
            .|.|..           |..:..|.:....|...||.:       ..:|..|.|.||:.:    |
Worm  1057 SIRLYNENDENAHTPIPIDFSKVMKDYDKGTVTIPTMN-------NTVLYPNQYSLFIEY----T 1110

  Fly   138 PQLF-----GYYRSSYKDPVTNKTRWLSATQFEPS-SARKAFPCFDEPGFKASFVVTLGYHKQFN 196
            ..:|     |...::|...:.|:..|:..|.||.. .||...||:|||.:|..|.|::.:.....
Worm  1111 GFIFQNPDEGDASNTYLGGLNNRKGWIFTTDFEGGPGARSLLPCWDEPSYKGQFEVSVFHPTDMI 1175

  Fly   197 ALSNMPVREIRPHESLANYIW--CEFQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNA 259
            ||||    |:....::.:..|  .:|..:..|||||:|..|..||...:....|.|.|.|.....
Worm  1176 ALSN----EVDIQRTIYDNGWTTTKFATTNQMSTYLLALCVGHFSNLATVTRTGVLTRVWTWSGM 1236

  Fly   260 IDQCDYAAEFGPKVLQYYEEFFGIRYPLPKIDQMAVPDF--SAGAMENWGLVKYRESTLLYSPTH 322
            ....::|.......:.:.|.:|...:||.|:|.||:|::  :|||||||||:....|..::.|.:
Worm  1237 EQYGEFALNVTAGTIDFMENYFSYDFPLKKLDVMALPEYTMNAGAMENWGLIIGEYSLFMFDPDY 1301

  Fly   323 SSLADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWH--SRDKGS 385
            ::..|..::|...|||:.|||||::||:.||.|::||||||.|....|:...:||.|  |.|...
Worm  1302 ATTRDITEVAETTAHEVVHQWFGDIVTLDWWNDIFLNEGFAQYWFANGIDNTFPEQHAYSIDYNR 1366

  Fly   386 LTALMTAFRLDSLVSSHPISRPIQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYL 450
            ......|.:.|.:..   :::|:  :::....|....|.||||:|.:::..:....|:.||..||
Worm  1367 FYMNHIALKYDCIPG---VAKPV--ISDTPPVFGIEPYYKGSALLNLLNNVLTPAVFQEGLSSYL 1426

  Fly   451 KLYAYKNAEQNNLWESLTTAAHQNGALPGH---YDINTIMDSWTLQTGFPVLNITRDYSTGTAEI 512
            ..|.|.||...|||.|||.||.::.....:   .|:::.||.:||||.:|::.:|
Worm  1427 TQYGYVNASPRNLWTSLTVAAQRHNITDWNGQPLDVSSFMDPYTLQTSYPIITLT---------- 1481

  Fly   513 TQERYLRNSQIPQADRVGC------WWVPLSYTTQDENDFN------NTSPKAWMECSSTDEGVP 565
                 ||.:...||::..|      |.|||...|....|||      ..:...|:      ..:|
Worm  1482 -----LRGTSTVQANQQSCMSDETLWNVPLFTQTPGALDFNWFVNFTGGNDATWL------RPLP 1535

  Fly   566 T--TIDHSAGPEEWLILNIQLSTPY-KANYDARNWKLLIDTLNSKDFQSIHVINRAQLIDDVLYF 627
            |  .:|::.            ||.: :.|||.::|..:...|.| :..::....||.|:||..:|
Worm  1536 TGYRVDNAG------------STSFARINYDDKSWYSIQAQLLS-NMNTMSSTTRAMLLDDANFF 1587

  Fly   628 AWTGEQDYETALQVTNYLRRERDLIPWKSALDNL-KLLNRILRQTPNFGSFKRYM----QKLLTP 687
            ..:|..:....|.:|.||..|..|.||:.|::.. ::|||...| |...:.:.|:    :..::.
Worm  1588 YQSGRWEMTKFLDLTLYLVNEDSLAPWEQAIEFFTEMLNRFQYQ-PEIDTVRNYVIQITKNAVSK 1651

  Fly   688 IYEHLHGM--ND----------TFSLMTQQDEVLLKTTVVN---VACQYDVS---DCVTQAQAYF 734
            ...:.:|:  ||          ..::..|..:|.|  |:.|   :.|:|.:|   .|
Worm  1652 FQWNTNGLWANDRIVQLLVNVNNLAVNRQSRQVAL--TLFNNFVLKCKYSLSGTGKC-------- 1706

  Fly   735 RRWRAETNPDENHPVPLNLRSTVYCTAISQGTE-EDWN-----FLWSRYRKSNVASERQTILSTL 793
                     ...||   |||...||..:.|... :|:.     :.|.......:.::...:|:.|
Worm  1707 ---------SGIHP---NLRQPTYCYGLRQSNNIDDFTTVNNLYSWFVQNAGYLQTDGSNLLNAL 1759

  Fly   794 GCSKEVWILQRYMEKSF----HPKS-----AIRKQDSSLCFQAVASREVGFLLAKQYFIENVELI 849
            ||.:.: .||:.|.:|.    :|.|     |:....|.:.:        .|||.....|.|....
Worm  1760 GCVQNL-DLQKTMLRSILSGDYPPSLLNSIAVHDDSSDVLY--------NFLLDNTQDILNAPFD 1815

  Fly   850 HKYYYPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRHFLKGIRQ--AMQQSLETMLTNVQWM 912
            ...|          :..:.:..||.|.|...:.|.|.|.:.|....|  ..:|.:.|:.:|..||
Worm  1816 FSLY----------VKAMFQNWSTSNQLELAKDFQNSSNYNLLNAAQKNIYKQGILTVNSNANWM 1870

  Fly   913 --------DWNYHKF 919
                    :|....|
Worm  1871 LIYKTPFLEWIQKNF 1885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	114/425 (27%)
		M1_APN_2	43..497	CDD:189008	140/479 (29%)
		ERAP1_C	578..904	CDD:288671	80/366 (22%)
T16G12.1	NP_499230.2	M1_APN_2	88..549	CDD:189008
		ERAP1_C	640..931	CDD:314669
		Peptidase_M1	999..1402	CDD:279741	115/429 (27%)
		ERAP1_C	1542..1839	CDD:314669	74/351 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2057
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.770