DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31445 and Lta4h

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_032543.2	Gene:	Lta4h / 16993	MGIID:	96836	Length:	611	Species:	Mus musculus

Alignment Length:	614	Identity:	147/614 - (23%)
Similarity:	239/614 - (38%)	Gaps:	150/614 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 RPQRYYLRILTLLESPDDLR--FAGNVQIVIKAL-QNTRNITLHSKNLTID-------ESRITLR 88
            |.|..:||.     |.|..|  ..|...:.:::. :|.|::||.:|:|||:       |.:.||.
Mouse    18 RTQHLHLRC-----SVDFARRTLTGTAALTVQSQEENLRSLTLDTKDLTIEKVVINGQEVKYTLG 77

  Fly    89 QISGAGNMDNCVSSTSVNPTHDYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYK-DPV 152
            :..|                            ..|:..::.||.:.....::  ....|:: .|.
Mouse    78 ESQG----------------------------YKGSPMEISLPIALSKNQEI--VIEISFETSPK 112

  Fly   153 TNKTRWLSATQ---------FEPSSA---RKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVR- 204
            ::..:||:..|         |....|   |...||.|.|..|.::...:...|:..||.: .:|
Mouse   113 SSALQWLTPEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMS-AIRD 176

  Fly   205 -EIRPHESLANYIWCEFQESVPMSTYLVAYSVNDFSFK---PSTLPNGALFRTWARPNAIDQCDY 265
             |....|..:..|: .|.:.||:..||:|..|.....:   |.||       .|:....:::.
Mouse   177 GEAPDPEDPSRKIY-RFNQRVPIPCYLIALVVGALESRQIGPRTL-------VWSEKEQVEKS-- 231

  Fly   266 AAEFG--PKVLQYYEEFFGIRYPLPKIDQMAV-PDFSAGAMENWGLVKYRESTLLYSPTHSSLAD 327
            |.||.  ..:|:..|:..| .|...:.|.:.: |.|..|.|||         ..|...|.:.||.
Mouse   232 ANEFSETESMLKIAEDLGG-PYVWGQYDLLVLPPSFPYGGMEN---------PCLTFVTPTLLAG 286

  Fly   328 KQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATY----VAGLGVQEIYPEWHSRDK-GSLT 387
            .:.|:||||||::|.|.|||||.|.|...|||||...|    :.|....|.:..:|:... |.|.
Mouse   287 DKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQ 351

  Fly   388 ALMTAFRLDSLVSSHPISRPIQMVTEIEE--SFDAISYQKGSAVL-RMMHLFMGEESFRTGLREY 449
            ..:..|.     .|||.::.:..:.:::.  ::.:|.|:||.|:| .:..|..|.|.|...|:.|
Mouse   352 NTIKTFG-----ESHPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAY 411

  Fly   450 LKLYAYKNAEQNNLWESLTTAAHQNGA-LPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEIT 513
            :|.::|::...:: |:|...:..::.. |....|.||    |....|.|.:....|.:
Mouse   412 VKKFSYQSVTTDD-WKSFLYSHFKDKVDLLNQVDWNT----WLYAPGLPPVKPNYDVT------- 464

  Fly   514 QERYLRNSQIPQADRVGCWWVPLSYTTQDENDFNNTSPKAWMECSSTD---------EGVPTTID 569
                |.|:.|..:.|    ||     |..|.|.::.|.....:.||..         :..|..:.
Mouse   465 ----LTNACIALSQR----WV-----TAKEEDLSSFSIADLKDLSSHQLNEFLAQVLQKAPLPLG 516

  Fly   570 HSAGPEE---------------WLILNIQ 583
            |....:|               ||.|.||
Mouse   517 HIKRMQEVYNFNAINNSEIRFRWLRLCIQ 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	105/429 (24%)
		M1_APN_2	43..497	CDD:189008	121/493 (25%)
		ERAP1_C	578..904	CDD:288671	4/6 (67%)
Lta4h	NP_032543.2	leuko_A4_hydro	6..608	CDD:274120	147/614 (24%)
		M1_LTA4H	6..450	CDD:189006	124/497 (25%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P09960	135..137		0/1 (0%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P09960	267..272		1/4 (25%)
		Leuk-A4-hydro_C	468..607	CDD:286244	18/87 (21%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P09960	564..566
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810