DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31445 and Anpep

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_032512.2	Gene:	Anpep / 16790	MGIID:	5000466	Length:	966	Species:	Mus musculus

Alignment Length:	915	Identity:	327/915 - (35%)
Similarity:	488/915 - (53%)	Gaps:	55/915 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 YNHYRLPTALRPQRYYLRILTLLESPDD---LRFAGNVQIVIKALQNTRNITLHSKNLTI---DE 82
            :|.||||..|.|..|.: ||....:|::   ..|.||..:.....|.|..|.:|||.|..   ..
Mouse    71 WNQYRLPKTLIPDSYRV-ILRPYLTPNNQGLYIFQGNSTVRFTCNQTTDVIIIHSKKLNYTLKGN 134

  Fly    83 SRITLRQISG--AGNMDNCVSSTSVNPTHDYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYR 145
            .|:.||.:.|  |.|:|    .|.:....:|.:.|....|:.|..|::...|..:|...|.|:||
Mouse   135 HRVVLRTLDGTPAPNID----KTELVERTEYLVVHLQGSLVEGRQYEMDSQFQGELADDLAGFYR 195

  Fly   146 SSYKDPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHE 210
            |.|.:....|.  ::.||.:.:.|||:|||||||..||.|.:||.|.....|||||..:|.:|:.
Mouse   196 SEYMEGDVKKV--VATTQMQAADARKSFPCFDEPAMKAMFNITLIYPNNLIALSNMLPKESKPYP 258

  Fly   211 SLANYIWCEFQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAID--QCDYAAEFGPKV 273
            ...:....||..:..|||||:||.|::|....|...||.....||||:|||  |.|||......:
Mouse   259 EDPSCTMTEFHSTPKMSTYLLAYIVSEFKNISSVSANGVQIGIWARPSAIDEGQGDYALNVTGPI 323

  Fly   274 LQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHE 338
            |.::.:.:...|||||.||:|:|||:||||||||||.||||:|::....||:::|:.:..|||||
Mouse   324 LNFFAQHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRESSLVFDSQSSSISNKERVVTVIAHE 388

  Fly   339 LAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHP 403
            |||||||||||:.||.|||||||||:||..||.....|.|:.:|...|..:.....:|:|.||||
Mouse   389 LAHQWFGNLVTVAWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHP 453

  Fly   404 ISRP---IQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWE 465
            :|.|   |:...:|.|.||:|:|.||::|:||:..|:.|:.|:.||..||..|.|.|....:|||
Mouse   454 LSSPADEIKTPDQIMELFDSITYSKGASVIRMLSSFLTEDLFKKGLSSYLHTYQYSNTVYLDLWE 518

  Fly   466 SLTTAAHQNGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRNSQ--IPQADR 528
            .|..|.:|..|:.....:.||||.|.||.||||:.:    :|.|.||:|:.:|.:|:  :.:...
Mouse   519 HLQKAVNQQTAVQPPATVRTIMDRWILQMGFPVITV----NTNTGEISQKHFLLDSKSNVTRPSE 579

  Fly   529 VGCWWV-PLSYTTQDENDFNNTSPKAWMECSSTDEGVPTTIDHSAGPEEWLILNIQLSTPYKANY 592
            ....|: |:.:....:.|      ..|::.....     :........||::|||.::..|..||
Mouse   580 FNYIWIAPIPFLKSGQED------HYWLDVEKNQ-----SAKFQTSSNEWILLNINVTGYYLVNY 633

  Fly   593 DARNWKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSA 657
            |..|||.|.:.|.: |...|.||||||:|.|....|.........||..|.:|.:|.:.:||::|
Mouse   634 DENNWKKLQNQLQT-DLSVIPVINRAQIIHDSFNLASAKMIPITLALDNTLFLVKEAEYMPWQAA 697

  Fly   658 LDNLKLLNRILRQTPNFGSFKRYMQKLLTPIYEHLHGMNDTF-----SLMTQQDEVLLKTTVVNV 717
            |.:|.....:..::..:|..|||::|.:||::.:.....:.:     :||.|.:|:    ..::.
Mouse   698 LSSLNYFTLMFDRSEVYGPMKRYLKKQVTPLFFYFQNRTNNWVNRPPTLMEQYNEI----NAIST 758

  Fly   718 ACQYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNV 782
            ||...:.:|.......:.:|....|.:..||   ||||||||.||:.|.||:|||.|.::|.:.:
Mouse   759 ACSSGLKECRDLVVELYSQWMKNPNNNTIHP---NLRSTVYCNAIAFGGEEEWNFAWEQFRNATL 820

  Fly   783 ASERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIENVE 847
            .:|...:.|.|.|||:||||.||:..:.:| ..|||||::....::||...|..|...:...|.:
Mouse   821 VNEADKLRSALACSKDVWILNRYLSYTLNP-DYIRKQDTTSTIISIASNVAGHPLVWDFVRSNWK 884

  Fly   848 LIHKYYYPQTRVMSRLLTPLSEQVSTINDLNKFRSFA--NDSRHFLKGIRQAMQQSLETMLTNVQ 910
            .:.:.|...:...:.|:..::.:.|:..:|.:...|.  |.:..|..|.| |::|:||....|:.
Mouse   885 KLFENYGGGSFSFANLIQGVTRRFSSEFELQQLEQFKADNSATGFGTGTR-ALEQALEKTRANID 948

  Fly   911 WMDWN 915
            |:..|
Mouse   949 WVKEN 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	171/410 (42%)
		M1_APN_2	43..497	CDD:189008	194/466 (42%)
		ERAP1_C	578..904	CDD:288671	104/332 (31%)
Anpep	NP_032512.2	Cytosolic Ser/Thr-rich junction	33..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..64
		Metalloprotease	69..966		327/915 (36%)
		M1_APN-Q_like	84..545	CDD:341064	193/467 (41%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	351..355		3/3 (100%)
		ERAP1_C	618..945	CDD:403137	106/336 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845887
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2057
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm42431
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.700