DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31445 and lvrn

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_031748993.1	Gene:	lvrn / 100496094	XenbaseID:	XB-GENE-980447	Length:	990	Species:	Xenopus tropicalis

Alignment Length:	969	Identity:	290/969 - (29%)
Similarity:	453/969 - (46%)	Gaps:	133/969 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 YNHYRLPTALRPQRYYLRILTLLESPDD--LRFAGNVQIVIKALQNTRNITLHS----------- 75
            :|:.|||..|.|..|.|.:...:|..::  ..|:|.|.|.|..:::|..:.|||
Frog    67 WNNLRLPHNLVPLHYDLELWPRMEEDEEGNYPFSGQVNITISCVEDTDVVLLHSIQLNFSDVGLR 131

  Fly    76 ----------------KNLTIDESRITLR------QISGAGNMDNCVSSTSVNPTHDYYIFHTCK 118
                            |:..:.|.|...|      .|.| ||:.  :::......|.|.:....:
Frog   132 LLGNKTIMYQSMEKDGKHNALQEGRAYKRLQDPTYDIHG-GNVS--INNVWTFEDHSYVVLELNE 193

  Fly   119 ELLAGNVYKLFLPFSADLTPQLFGYYRSS-------YKDPVTNKTRWLSATQFEPSSARKAFPCF 176
            .|:|||:|.|.|.::        |:.|.:       |||  .|..:.:.|:..||..||..:|||
Frog   194 RLVAGNLYLLELNYT--------GFIRQNTALFITHYKD--FNIDKAVVASLLEPEYARAVYPCF 248

  Fly   177 DEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLANYIW--CEFQESVPMSTYLVAYSVNDFS 239
            |||..||:|.:.|.::..:.||||||...:...|.:...||  ..|..:..||||:.|:.:.||.
Frog   249 DEPALKATFKIRLVHNSSYVALSNMPAVAVSEREDIDGSIWTVTTFDTTPKMSTYITAFVICDFD 313

  Fly   240 FKPSTLPNGALFRTWARPNAIDQ--CDYAAEFGPKVLQYYEEFFGIRYPLPKIDQMAVPDFSAGA 302
            :...| ..|...|.|||...:.:  ...|......:|.|.|:.|.:.|||.|.|.:|:||....|
Frog   314 YVNIT-ERGNEIRVWARKEVVQKGFASLALSIAGPLLSYMEDLFNVSYPLQKTDFVALPDLDVEA 377

  Fly   303 MENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATYVA 367
            ||||||:.:.|..|:|.|...|...|...:.:::||:||||||||||||||||||||||||||:.
Frog   378 MENWGLITFIEEALIYDPRQKSSNSKFRTSLIVSHEIAHQWFGNLVTMKWWTDLWLNEGFATYME 442

  Fly   368 GLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHPISRPIQMVTEIEES--FDAISYQKGSAVL 430
            ..|:..:..:....:..::..|...|..|....:..:|...:.:.|.:.|  |:..:|.||||::
Frog   443 YFGITFLDSKLELNELFTMHNLQPIFERDVGAHAKTVSMKEEELYEADSSHMFNEFTYDKGSALV 507

  Fly   431 RMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTT-AAHQNGA-LPGHYDINTIMDSWTLQ 493
            ||:..|:.|:.|..|:..|||.:::.|.:|::||..|.. ..||:.. ||  ..:..||.|||.|
Frog   508 RMLSSFLTEKLFIKGISSYLKTFSFSNVDQDDLWNHLQMFIDHQDEVRLP--TTLRHIMQSWTWQ 570

  Fly   494 TGFPVLNITRDYSTGTAEITQERY-LRNSQIPQADRVGCWWVPLSYTTQDENDFNNTSP-KAWME 556
            .|.|:|.:    .|.|.|:.:|.: ..|:....:|....|.||:::..      |.|.. ..|::
Frog   571 RGIPLLTL----DTTTGELAEELFKTDNTDNITSDSNHTWIVPVTWMK------NGTKQISLWLD 625

  Fly   557 CSSTDEGVPTTIDHSAGPEEWLILNIQLSTPYKANYDARNWKLLIDTLNSKDFQSIHVINRAQLI 621
            ..|....|.||     ..:||::|||.::..|:.||:..||..|...|.:.. :.:..:||.|||
Frog   626 SKSKVFPVLTT-----AADEWIVLNINVTGYYRTNYNKENWNRLAKQLEANP-KVVPTVNRIQLI 684

  Fly   622 DDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDNLKLLNRILRQTPNFGSFKRYMQKLLT 686
            :|....|..|..|:.|||.:|.||.:|.::..|.:.|.::...:..|....||..||:|:.|.::
Frog   685 EDAFILARYGYTDHGTALSLTKYLEKEEEINVWYTVLKHVTSSDYPLITYTNFPLFKKYILKRIS 749

  Fly   687 PIYEHL---------HGMNDTFSLMTQQDEVLLKTTVVNVACQYDVSDCVTQAQAYFRRWRAETN 742
            |||:..         ...:|.|  :....|::|||     ||.:.:.||:..|...:..|....:
Frog   750 PIYQRFANSIRRNFDEAADDYF--IQVHIELILKT-----ACSFGLQDCLQLAHQLYATWMKNCS 807

  Fly   743 PDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNVASERQTILSTLGCSKEVWILQRYME 807
               .:.:|.::|:.:.|.||:.|.|::|.|.|....||. ..||..:...|.|:||.|:|.||:|
Frog   808 ---GNVIPESIRNPICCYAIANGGEKEWEFAWKMVNKSE-EIERDLLFYALSCTKEPWLLHRYLE 868

  Fly   808 KSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIENVELIHKYYYPQTRV----------MSR 862
            .|..    :.|..:...|..|...|:|..:|.::..||.:.||..:.|:..|          .|:
Frog   869 YSLE----MYKSSAFTIFLDVIKNEIGRHIAWEFLKENWQRIHDIFGPRDTVDFYTVLLPTFASK 929

  Fly   863 LLTPLSEQV------STINDLNKFRSFANDSRHFLKGIRQAMQQSLE-TMLTNVQWMDW 914
            ..:.|..|.      :|||:        |.....|:.:....::||. |...|.:.:.|
Frog   930 AASDLQFQEIQLFINTTINE--------NQRERILEQVENKWRKSLGWTSKINDEILTW 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	141/445 (32%)
		M1_APN_2	43..497	CDD:189008	163/503 (32%)
		ERAP1_C	578..904	CDD:288671	96/351 (27%)
lvrn	XP_031748993.1	M1_APN-Q_like	79..568	CDD:341064	161/504 (32%)
lvrn	XP_031748993.1	ERAP1_C	641..945	CDD:403137	90/319 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010