DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31445 and trhde

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_002939988.3	Gene:	trhde / 100489066	XenbaseID:	XB-GENE-1013649	Length:	1020	Species:	Xenopus tropicalis

Alignment Length:	921	Identity:	302/921 - (32%)
Similarity:	492/921 - (53%)	Gaps:	50/921 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 YNHYRLPTALRPQRYYLRILTLLESPDDLRFAGNVQIVIKALQNTRNITLHSKNLTIDESRITLR 88
            :.:.||||.|||..|.|.:...:   ::..|.|.|.:.|:.|.::|.|.:|:..||::..::...
Frog   131 WTYLRLPTHLRPLHYNLMVTAFM---NNFTFCGEVNVEIECLNSSRYIVVHAHRLTVERVQVAED 192

  Fly    89 QISGAGNMDNCVSSTSVNPTHDYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYKDPVT 153
            :::|    :..||.....|.:...:....:.|.|...|.|.:.:||.:..:|.|::||||  .:.
Frog   193 RVAG----EVKVSHYFPYPQNQVLVVVLNRSLEAQKSYNLKIIYSAIIENELLGFFRSSY--VLH 251

  Fly   154 NKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLANYIWC 218
            .:.|.|:.|||.|..|||||||||||.:||:|.:::.:...:.:|||||| |....|. ..::..
Frog   252 GERRSLAVTQFSPIHARKAFPCFDEPIYKATFKISIRHQTSYLSLSNMPV-ETSVFEE-GGWVTD 314

  Fly   219 EFQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAI--DQCDYAAEFGPKVLQYYEEFF 281
            .|.::..||||.:|::|.:|:||.:...:|.:.|.:|||:||  ...|||.....::|::||::|
Frog   315 HFSQTPLMSTYYLAWAVCNFTFKEAVTQSGVVVRLYARPDAIRRGSGDYALNITKRLLEFYEDYF 379

  Fly   282 GIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGN 346
            .:.|.|||:|.:|||.....|||||||..:.|..:|..|:.||::...|:..||.||:.|||||:
Frog   380 RVPYSLPKLDLLAVPKHPYAAMENWGLSVFVEQRILLDPSISSISYLLDVTMVIVHEICHQWFGD 444

  Fly   347 LVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLT-ALMTAFRLDSLVSSHPISRPIQM 410
            |||..||.|:||.||.|.|...:|...:||.|:...:..|| .|.....||.|.||||:|:.:..
Frog   445 LVTPIWWEDVWLKEGLAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLK 509

  Fly   411 VTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQNG 475
            .|:|:..||.|:|:||:|::||:..|||.:.|:.||::||..:.|.||.:|:||.:||......|
Frog   510 ATDIDRVFDWIAYKKGAALIRMLANFMGHKVFQRGLQDYLTTHKYGNAARNDLWNTLTKVLKNEG 574

  Fly   476 ALPGHYDINTIMDSWTLQTGFPVLNITR-DYSTGTAEITQERYLRNSQIPQAD-----RVGCWWV 534
            .|   .:|..:||.||||.|:||:.|.| |.:.....||||.:|.|......|     :...|.:
Frog   575 KL---LNIREVMDQWTLQMGYPVITILRNDTTDDIITITQEHFLYNIDKRTRDKEFRNKSSLWQI 636

  Fly   535 PLSYTTQDENDFNNTSPKA--WMECSSTDEGVPTTIDHSAGPEEWLILNIQLSTPYKANYDARNW 597
            ||:...   .:.::.||:|  |:...|....:| ::|.|    .|::.|:.....::.|||.|||
Frog   637 PLTIAV---GNTSHISPQAIIWVSNKSEYHRIP-SLDES----NWVLGNLDQIGYFRVNYDVRNW 693

  Fly   598 KLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDNLK 662
            :||.|.| .::.:.|.|.|||.||||....|..|.......|::..||..|:|.:||.:|...|.
Frog   694 RLLTDQL-MRNSEVISVSNRAALIDDAFNLARAGYLTQNIPLEIIRYLSEEKDFLPWHAASRALY 757

  Fly   663 LLNRILRQTPNFGSFKRYMQKLLTPIYEHL----HGMNDTFSLMTQQDEVLLKTTVVNVACQYDV 723
            .|:::|.:|.::..|..|:.|.::.:|..|    :|.|.:....:.|.|. |:..|:.:||.:..
Frog   758 PLDKLLDRTEDYSIFSEYILKQVSTMYFRLGWPTNGQNGSAVPTSYQTEE-LRREVIMLACSFGN 821

  Fly   724 SDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNVASERQT 788
            ..|..:|......|.:    ...:.:|.|:|..||||.:|...|:.|.|:|.::..|...||::.
Frog   822 KQCHQKAATMISDWIS----SNRNRIPPNVRDIVYCTGVSLMDEDVWEFIWMKFHSSTAVSEKKI 882

  Fly   789 ILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIENVELIHKYY 853
            :|..|.||....:|.|.:..|.: ...:..||:......||....|..||.::|.:..::::..|
Frog   883 LLEALTCSDNRNLLNRLLNLSLN-SEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNARY 946

  Fly   854 YPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRHFLKGIRQAMQQSLETMLTNVQWM----DW 914
            .....:.|:|::.::|.::|..:||:.:.|.  .:|.......::.::.||:..||:|.    |.
Frog   947 GEALFMNSKLISGVTEFLNTEEELNELKDFI--QQHKGGSAVASLSRATETVDANVRWQHLYRDE 1009

  Fly   915 NYHKFSRTIRH 925
            .:....:|::|
Frog  1010 LFQWLRKTVKH 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	150/400 (38%)
		M1_APN_2	43..497	CDD:189008	172/456 (38%)
		ERAP1_C	578..904	CDD:288671	89/329 (27%)
trhde	XP_002939988.3	M1_APN-Q_like	143..588	CDD:341064	170/458 (37%)
trhde	XP_002939988.3	ERAP1_C	673..998	CDD:403137	92/333 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6063
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.020