DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31445 and lnpep

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_002933474.1	Gene:	lnpep / 100216271	XenbaseID:	XB-GENE-950921	Length:	1024	Species:	Xenopus tropicalis

Alignment Length:	920	Identity:	297/920 - (32%)
Similarity:	469/920 - (50%)	Gaps:	105/920 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RLPTALRPQRYYLRILTLLESPDDLRFAGNVQIVIKALQNTRNITLHSKNLTIDESRITLRQISG 92
            |||.:::|..|   :|||......:.|||.|||.:....::.||.|||..|.|.::.::   ::.
Frog   166 RLPNSIKPVHY---VLTLHPDMTTMYFAGTVQIKLNITASSNNIVLHSSGLRIIKAHVS---VTE 224

  Fly    93 AGNMDNCVSSTSVNPTHDYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYKDPVTNKTR 157
            ...||   :.....||.:.......:.|..|....|.:.::::.:...:|:|:..|.:. .|| |
Frog   225 GTTMD---AEVLEYPTFEEIAIILPESLPKGKECLLTIQYTSNFSSTYYGFYKIDYMEK-GNK-R 284

  Fly   158 WLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLANYIWCEFQE 222
            .|:||||||.:|||.|||||||.||::|.:.:..::...:|||||  :.:........:..|:..
Frog   285 SLAATQFEPLAARKVFPCFDEPAFKSTFQINIIRNQSMISLSNMP--KAKTSTMSDGLLLDEYST 347

  Fly   223 SVPMSTYLVAYSVNDFSFKPSTL-PNGALFRTWARPNAIDQCDYAAEFGPKVLQYYEEFFGIRYP 286
            ||.|||||||:.|.|  .|.:|. .|..|...:|.|..:||..||.:...|:|.:|..::.|.||
Frog   348 SVNMSTYLVAFIVGD--IKNTTQETNDTLVSVYAVPEKMDQVKYALDSAMKLLYFYSNYYNIAYP 410

  Fly   287 LPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVTMK 351
            |.|:|.:|:|||.|||||||||:.:||:.|||....||:||||.:..|||||||||||||||||:
Frog   411 LKKLDLVAIPDFQAGAMENWGLITFRETALLYKEDSSSVADKQSITKVIAHELAHQWFGNLVTME 475

  Fly   352 WWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHPISRPIQMVTEIEE 416
            ||.|||||||||||:..:.:..::||.:| :...|....||.:.|||.:|||||..||...:|||
Frog   476 WWNDLWLNEGFATYMEYVSMSSLFPELNS-ENSFLKMRFTALQKDSLNASHPISTDIQSPEQIEE 539

  Fly   417 SFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQNGALPGHY 481
            .||.:||.||:::|.|:..|:.|:.|...:.|||:.:.|.:...::||:|:....::|.
Frog   540 MFDDLSYIKGASILLMLQAFLSEDVFHHCIMEYLQAHQYGSTTSDSLWDSMNVVTNKNP------ 598

  Fly   482 DINTIMDSWTLQTGFPVLNITRDYSTGTAEIT--QERYLRNSQIPQADRVG-CWWVPLSYTTQDE 543
            ::..:|.:||.:.|:|::...|.    ..|||  |||:||......|.... .|.:||:|.|:
Frog   599 NVKNMMKTWTQKAGYPLVTALRK----GEEITVQQERFLRTPSPDHATNASTVWHIPLTYVTR-- 657

  Fly   544 NDFNNTSPKAWMECSSTDEGVPTTIDH--------------SAGPEEWLILNIQLSTPYKANYDA 594
                        :||    |:....|:              |..|  |:..|:.::..|..:|.|
Frog   658 ------------KCS----GIEPQCDNIYLLKEVTGRINVSSEFP--WVKFNVNMTGYYIVDYGA 704

  Fly   595 RNWKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALD 659
            ..|..||..| .:|...:|..:||.||.|:...|..|:.....|.::..||..|.:..|...||:
Frog   705 DGWDALIKQL-LRDHTVLHSSDRANLIHDIFMLAGVGKVPLAKAFELLGYLANETNSAPITQALN 768

  Fly   660 NLKLLNRILRQTPNFGSFKRYMQKLLTPIYEHLHGMNDTFSLMTQ--QDEVL-----LKTTVVNV 717
            ....::.||        .||.:.:|...:.|  .|:....:|:.|  :||..     |::::::.
Frog   769 QFYHIHGIL--------LKRGLDELSDKVME--RGLKLLSNLINQTWEDEGTLAERELRSSLLDF 823

  Fly   718 ACQYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNV 782
            ||...:..||.:|...|..||.     .|..:|.::...|:  .:...|.|.|.|||.:|..|..
Frog   824 ACSSGLQSCVDKAMELFNIWRL-----NNTRIPTDVMKVVF--KVGAKTAEGWAFLWDKYTTSLY 881

  Fly   783 ASERQTILSTLGCS----KEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFI 843
            .:|::.||..|..:    |..|::|..::...     ||.|:.......::....|:|||.::..
Frog   882 ETEKRKILEALASTDNGRKLQWLMQESLDGGL-----IRSQELPAVLGFISKGSPGYLLAWEFAK 941

  Fly   844 ENVELIHKYYYPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRHFLKGIRQAM---QQSLETM 905
            :|.:||.:.:.|.:..:..:::..:...||...||:..:|.|.:    ||..:.|   ::::||:
Frog   942 QNWDLITQKFMPGSFPIQSIVSTTTYHFSTDTHLNEVIAFFNST----KGKSREMWCVKEAVETI 1002

  Fly   906 LTNVQWMDWN 915
            ..|::||..|
Frog  1003 KFNIEWMKNN 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	167/398 (42%)
		M1_APN_2	43..497	CDD:189008	181/454 (40%)
		ERAP1_C	578..904	CDD:288671	82/339 (24%)
lnpep	XP_002933474.1	M1_APN-Q_like	174..609	CDD:341064	180/456 (39%)
lnpep	XP_002933474.1	ERAP1_C	687..1003	CDD:378732	85/342 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020