DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31445 and erap2

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_005165525.1	Gene:	erap2 / 100144556	ZFINID:	ZDB-GENE-080402-6	Length:	935	Species:	Danio rerio

Alignment Length:	996	Identity:	301/996 - (30%)
Similarity:	469/996 - (47%)	Gaps:	138/996 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFVLAIGLD------LSVANSIS-----------RYNHYRLPTALRPQRYYLRILTLLESPDDL 52
            |||::.:.|:      .|.:||.:           .::..|||..:.|..|:|.|...|.:   |
Zfish     4 LLFLILLFLESLCYVQSSESNSPTGDNLATDGLPFPWSKVRLPNYIVPVHYHLLIHPNLTT---L 65

  Fly    53 RFAGNVQIVIKALQNTRNITLHSKNLTI------DESRITLRQISGAGNMDNCVSSTSV--NPTH 109
            .|.|:|:|.|....||..:.||||||.|      ||....|.:           .:.||  .|.|
Zfish    66 SFTGSVKIEIDVKNNTNWVVLHSKNLKIYTATVLDEHEAHLSE-----------KTLSVLEYPLH 119

  Fly   110 DYYIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYKDPVTNKTRWLSATQFEPSSARKAFP 174
            :.....:.|.|.:|..|.|:|.|.|.|:....|:|:|:|:.. :.:||.|::|.|||:|||.|.|
Zfish   120 EQIAIFSPKILTSGEKYFLYLEFGAPLSDGFHGFYKSTYRTK-SGETRVLASTHFEPTSARMALP 183

  Fly   175 CFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLANYIWCE-FQESVPMSTYLVAYSVNDF 238
            |||||.|||::.|.:.......||||||:.:.   ..::|.::.: |:.||.||:||:|:.:.||
Zfish   184 CFDEPVFKANYTVRIRRGPSHIALSNMPLEQT---VEISNGLFEDHFEASVKMSSYLLAFIICDF 245

  Fly   239 SFKPSTLPNGALFRTWARPNAIDQCDYAAEFGPKVLQYYEEFFGIRYPLPKIDQMAVPDFSAGAM 303
            .........|.....:|.|....|..||.|...::|::||::|.|.|||||:|.:|:|||.:|||
Zfish   246 KSVSGLTATGINISIYAVPEKWHQTQYALEAALRLLEFYEQYFNILYPLPKLDLIAIPDFESGAM 310

  Fly   304 ENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATYVAG 368
            |||||..|||::|||.|..||.:||..:..||.||||||||||||||.||.|:|||||||.|:..
Zfish   311 ENWGLTTYRETSLLYDPDISSASDKLWVTMVIGHELAHQWFGNLVTMDWWNDIWLNEGFARYMES 375

  Fly   369 LGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHPISRPIQMVTEIEESFDAISYQKGSAVLRMM 433
            :.|:.:|||....|. .|.....|...|||.||.|||...:..|:|:|.||.:||:||:.:|.|:
Zfish   376 VSVEAVYPELKVEDH-FLDTCFGAIGRDSLNSSRPISSLAESPTQIKEMFDTVSYEKGACILHML 439

  Fly   434 HLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQNGALPG------------------- 479
            ..|:.:|.|::|:..||:.::|.||...:||:||.....:.....|
Zfish   440 RHFLTDEGFQSGIIRYLRRFSYCNARNEDLWDSLIKTCSEEDFAAGEYCYSSAQATKNAYRFAGE 504

  Fly   480 HYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRNSQIPQADRVG--------CWWVPL 536
            |.|:..:|::||||.|.|::.:.|  ......|.|||:|:   |...|...        .|.:||
Zfish   505 HVDLKKMMNTWTLQKGIPLVTVKR--QGRKLHIGQERFLK---IVLPDDPSWHSLQDGYLWHIPL 564

  Fly   537 SYTTQDENDFNNTSPKAWMECSSTDEGVPTTIDHSAG------PEEWLILNIQLSTPYKANYDAR 595
            :|.|                 |.:|..|...:|..:.      ..:|:.||..::..|..:||..
Zfish   565 TYKT-----------------SHSDHEVKHILDKKSDVLLLDEHVDWVKLNTDMNGYYIVHYDEE 612

  Fly   596 NWKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDN 660
            .|..|.:.| ..:..::...:||.||.:.......|....:.||.:..||:.|...:|....|..
Zfish   613 GWNALTELL-KVNHTALSFKDRASLIHNAFQLVTAGRLSLDRALDLIAYLKSETHNVPLLQGLGY 676

  Fly   661 LKLLNRILRQ------TPNFGSFKRYMQKLLTPIYEHLHGMNDTFSLMTQQDEVL-----LKTTV 714
            |:...:::.:      |.|   .|.|:          |....|.....:..|:.:     |:..|
Zfish   677 LQSFYKLIEKRKIADVTHN---LKTYI----------LQYFKDVIDKQSWSDDGMVSDRRLREDV 728

  Fly   715 VNVACQYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEED--WNFLWSRY 777
            :::||..|...|:.:|:..|..|   ...:....:|.::..|||..    |.::|  |.:|..:|
Zfish   729 LSLACDLDYPPCLEKAERLFVSW---VKSNGTISLPTDVSETVYMV----GAQDDSGWVYLLRQY 786

  Fly   778 RKSNVASERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYF 842
            ..|...:|:...||.|..||:...|.|.::.... .:.|:.|:.......||...||..||..:.
Zfish   787 GVSMCETEKSKFLSALTSSKDSEKLSRLLQLGME-GTVIKTQNLPSLIYMVARNPVGHFLAWDFV 850

  Fly   843 IEN-VELIHKYYYPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRHFLKGIRQAMQQSLETML 906
            .:: .||:.|:......:...::..:: |.|:..:|.:..||....:..:..:| .:|.:.|.:.
Zfish   851 KKHWNELVEKFPLGSFGIREIIVGTVT-QFSSTEELREVESFFKSIQEQVSQLR-IIQVATENVE 913

  Fly   907 TNVQWMDWNYHKFSRTIRHHL 927
            .|:.|:..|.......::..|
Zfish   914 KNIVWLKRNLETMRTWLQRRL 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	171/406 (42%)
		M1_APN_2	43..497	CDD:189008	190/481 (40%)
		ERAP1_C	578..904	CDD:288671	73/339 (22%)
erap2	XP_005165525.1	Peptidase_M1	44..432	CDD:279741	171/406 (42%)
		M1_APN_2	52..522	CDD:189008	193/488 (40%)
		ERAP1_C	595..911	CDD:288671	73/339 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590501
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850