DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31445 and trhde.1

DIOPT Version :9

Sequence 1:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_001345457.3	Gene:	trhde.1 / 100006808	ZFINID:	ZDB-GENE-170406-2	Length:	994	Species:	Danio rerio

Alignment Length:	967	Identity:	314/967 - (32%)
Similarity:	496/967 - (51%)	Gaps:	100/967 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFVLAIGLDLSV--------------ANSISR----------------------YNHYRLPTAL 33
            |:.|.||.:.|||              ||..|.                      :.|.|||..|
Zfish    50 LIIVTAIAITLSVSFERCAAESSGALAANGSSNSKWKQSRDGNISHRDSEDGQQPWRHLRLPATL 114

  Fly    34 RPQRYYLRILTLLESPDDLRFAGNVQIVIKALQNTRNITLHSKNLTIDESRITLRQISGAGNMDN 98
            ||:.|.||:...:|   :..|:|.|.|..:.:.:|:.|.|||..|.:|:. :.......||.|
Zfish   115 RPRHYDLRLTVHME---NFSFSGEVNIEFECVNSTKLIVLHSDRLELDKV-LVFSDSKKAGAM-- 173

  Fly    99 CVSSTSVNPTHDY-----YIFHTCKELLAGNVYKLFLPFSADLTPQLFGYYRSSYKDPVTNKTRW 158
                 .:.....|     |:....:|:.....||:.:.|:|.:..:|.|::||||.  :..:.|:
Zfish   174 -----RIQRRFHYQPKQVYVIALHREMKPLRTYKINITFTAHIEHELLGFFRSSYM--LNGERRF 231

  Fly   159 LSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLANYIWCEFQES 223
            |:.|||.|:.|||||||||||.:||:|.|:|.:...:.:||||||......|.  .::...|..:
Zfish   232 LAVTQFSPTHARKAFPCFDEPIYKATFRVSLKHESSYQSLSNMPVEATTSDED--GWVTNHFSRT 294

  Fly   224 VPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAID--QCDYAAEFGPKVLQYYEEFFGIRYP 286
            ..||||.:|::|.:|::|.:...||.|.|.:|||:||.  ..|||.....::||:|:::|.::|.
Zfish   295 PRMSTYYLAWAVCNFTYKEAVADNGVLIRLYARPDAIQSGSGDYALRITKRLLQFYQDYFKVKYS 359

  Fly   287 LPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHELAHQWFGNLVTMK 351
            |||:|.:|||.....|||||||..:.|..:|..|..||.:.:.:|..|:.||:.|||||:|||..
Zfish   360 LPKLDLLAVPKHPYSAMENWGLSVFVEQKILLDPEVSSFSYQMELTVVVVHEICHQWFGDLVTPV 424

  Fly   352 WWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLT-ALMTAFRLDSLVSSHPISRPIQMVTEIE 415
            ||.|:||.||||.|...:|...::|:|:...:..|| .|.....||.|.||||||:.:...|:|:
Zfish   425 WWEDVWLKEGFAHYFEYIGADFLFPKWNMEKQRFLTDVLHEVMLLDGLASSHPISQQVFEATDID 489

  Fly   416 ESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQNGALPGH 480
            ..||.|:|:||:|::||:...||:..|:..|.:||..:.|.||.:::||..|:.|..:.|.
Zfish   490 RVFDWIAYKKGAALIRMLANVMGQTLFQRALNDYLMTHMYGNAARDDLWNKLSEAMQREGK---- 550

  Fly   481 YDIN--TIMDSWTLQTGFPVLNITR-DYSTGTAEITQERYLRNS----QIPQA-DRVGCWWVPLS 537
             |||  .:||.||||.|:||:.|:: |....:..|:||.::.::    |.|:. ::...|.:||:
Zfish   551 -DINITQVMDRWTLQMGYPVVTISKNDSLDNSITISQEHFVYDTDAKIQNPELFNKSFQWQIPLT 614

  Fly   538 YTTQDENDFNNTSPKAWMECSSTDEGVPTTIDHSAGPEEWLILNIQLSTPYKANYDARNWKLLID 602
            ....:.:.. :|....|:    |::.....:.|..| |.||:.||..:..::.|||..||||||.
Zfish   615 LAVGNASHI-STETIIWV----TNKSEAHRVGHMVG-ETWLLGNINQTGYFRVNYDLHNWKLLIQ 673

  Fly   603 TLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDNLKLLNRI 667
            .|.|.. ..|.|.|||.|||||...|..|.......||:.:||.:|.:.:||.:|...|..|:::
Zfish   674 QLMSNP-TIISVGNRAGLIDDVFNLARAGYLPQNVPLQMISYLSQEPEFLPWHAASRALYQLDKL 737

  Fly   668 LRQTPNFGSFKRYMQKLLTPIYEHL----HGMNDTFSLMTQQDEVLLKTTVVNVACQYDVSDCVT 728
            |.:|.:...|..|:.:.:.|.|..|    ...:.:|.....|.|. |:..|:.:||.:....|..
Zfish   738 LDRTLDHSLFSDYVLRQVEPKYHKLGWPATSPDGSFMHSAYQTEE-LQREVIMLACSFGNKHCHR 801

  Fly   729 QAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNVASERQTILSTL 793
            ||.:....|   .:.::|. :|.|:|..||||.:|...|:.|.|:|.::..|...||::.:|..|
Zfish   802 QAVSLISDW---ISSNKNR-IPPNVRDIVYCTGVSLMDEDVWEFIWMKFHSSTAVSEKKVLLEAL 862

  Fly   794 GCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIENVELIHKYYYPQTR 858
            .||..:::|.|.:..|. ....:..||.......||...:|..||.:||.|..::::..|.....
Zfish   863 TCSDNIFLLNRLLNLSL-TSDLVPDQDVIDVIIHVARNPLGRHLAWRYFREKWDILNSRYGEALF 926

  Fly   859 VMSRLLTPLSEQVSTINDLNKFRSF----ANDSRHFLKGIRQAMQQSLETMLTNVQW 911
            :.|:|::.::|.::|..:||:.:.|    ..:|       ..|..:::|.:..||:|
Zfish   927 MNSKLISGVTEFLNTEAELNELKEFILTSGGES-------APAFARAVEIVQANVKW 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	154/405 (38%)
		M1_APN_2	43..497	CDD:189008	174/463 (38%)
		ERAP1_C	578..904	CDD:288671	97/333 (29%)
trhde.1	XP_001345457.3	Peptidase_M1	109..500	CDD:279741	154/405 (38%)
		M1_APN_2	118..568	CDD:189008	177/469 (38%)
		ERAP1_C	649..968	CDD:288671	97/332 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590512
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840