DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31441 and ZNF568

DIOPT Version :9

Sequence 1:	NP_731558.1	Gene:	CG31441 / 326139	FlyBaseID:	FBgn0051441	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_940941.2	Gene:	ZNF568 / 374900	HGNCID:	25392	Length:	644	Species:	Homo sapiens

Alignment Length:	339	Identity:	86/339 - (25%)
Similarity:	148/339 - (43%)	Gaps:	54/339 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 FNKSNYHFISILENIT---------DMYLEFDT---------TLPHLICQCCKV--QLDRILTFR 70
            |.|..||..|.:  :|         |...:||.         ..|:...:|.|.  :.:.::|.:
Human   207 FGKPFYHCASYV--VTPFKCNQCGQDFSHKFDLIRHERIHAGEKPYECKECGKAFSRKENLITHQ 269

  Fly    71 N--------KCLEVHKSFMAANRKLLRKKAIVDEELDKPDVEKLQQDLWDHTDQEMCVAMADTAG 127
            .        ||.|..|:|:..: .|:|...|...|  ||...|   |.|.        |.:..:.
Human   270 KIHTGEKPYKCNECGKAFIQMS-NLIRHHRIHTGE--KPYACK---DCWK--------AFSQKSN 320

  Fly   128 LLREDH-NDNEK---AKDAEDATQNEKNQEEQVQVQTEEVEH-CQEQLHNMSIISKGVSARVPKR 187
            |:..:. :..||   .|:...:...::|..|..::.|.|..: |.|.....|.:|   |..:..|
Human   321 LIEHERIHTGEKPYECKECGKSFSQKQNLIEHEKIHTGEKPYACNECGRAFSRMS---SVTLHMR 382

  Fly   188 TKRNSKSWFCDQCGGVFKSSTYLKLHLQRHSGHKPFACDICQAKYYTDNEMRRHRILHTDARPYA 252
            :....|.:.|::||..|...:...:|::.|:|.||:.|..|...:...:.:..|...||..:||.
Human   383 SHTGEKPYKCNKCGKAFSQCSVFIIHMRSHTGEKPYVCSECGKAFSQSSSLTVHMRNHTAEKPYE 447

  Fly   253 CRFCSKTYRGCSSKVVHERTHTNERPFQCQHCDKAFTSTSTRQKHEMLHTNQRKYHCEICDQWFL 317
            |:.|.|.:....:.:.|::.||.|:|::|..|.|||...|...:|:.:||.::.|.|.:|.:.|.
Human   448 CKECGKAFSRKENLITHQKIHTGEKPYECSECGKAFIQMSNLIRHQRIHTGEKPYACTVCGKAFS 512

  Fly   318 RSSHLTLHQSTKLH 331
            :.|:||.|:  |:|
Human   513 QKSNLTEHE--KIH 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31441	NP_731558.1	zf-AD	7..82	CDD:285071	18/83 (22%)
		COG5048	<174..337	CDD:227381	48/158 (30%)
		C2H2 Zn finger	197..217	CDD:275370	5/19 (26%)
		C2H2 Zn finger	225..245	CDD:275368	3/19 (16%)
		C2H2 Zn finger	253..273	CDD:275368	4/19 (21%)
		zf-H2C2_2	268..290	CDD:290200	10/21 (48%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		C2H2 Zn finger	309..328	CDD:275368	7/18 (39%)
ZNF568	NP_940941.2	KRAB	48..102	CDD:214630
		KRAB	48..87	CDD:279668
		C2H2 Zn finger	224..244	CDD:275368	3/19 (16%)
		zf-H2C2_2	236..261	CDD:290200	4/24 (17%)
		COG5048	248..634	CDD:227381	77/296 (26%)
		C2H2 Zn finger	252..272	CDD:275368	3/19 (16%)
		zf-H2C2_2	264..289	CDD:290200	6/24 (25%)
		C2H2 Zn finger	280..300	CDD:275368	6/20 (30%)
		zf-H2C2_2	292..317	CDD:290200	10/37 (27%)
		C2H2 Zn finger	308..328	CDD:275368	5/30 (17%)
		zf-H2C2_2	320..345	CDD:290200	4/24 (17%)
		C2H2 Zn finger	336..356	CDD:275368	3/19 (16%)
		zf-H2C2_2	348..373	CDD:290200	6/24 (25%)
		C2H2 Zn finger	364..384	CDD:275368	6/22 (27%)
		zf-H2C2_2	380..401	CDD:290200	6/20 (30%)
		C2H2 Zn finger	392..412	CDD:275368	5/19 (26%)
		zf-H2C2_2	408..429	CDD:290200	7/20 (35%)
		C2H2 Zn finger	420..440	CDD:275368	3/19 (16%)
		zf-H2C2_2	432..457	CDD:290200	8/24 (33%)
		C2H2 Zn finger	448..468	CDD:275368	4/19 (21%)
		zf-H2C2_2	460..485	CDD:290200	10/24 (42%)
		C2H2 Zn finger	476..496	CDD:275368	7/19 (37%)
		zf-H2C2_2	488..513	CDD:290200	7/24 (29%)
		C2H2 Zn finger	504..524	CDD:275368	8/21 (38%)
		zf-H2C2_2	516..541	CDD:290200	5/11 (45%)
		C2H2 Zn finger	532..552	CDD:275368
		zf-H2C2_2	544..569	CDD:290200
		C2H2 Zn finger	560..580	CDD:275368
		zf-H2C2_2	572..597	CDD:290200
		C2H2 Zn finger	588..608	CDD:275368
		zf-H2C2_2	601..625	CDD:290200
		C2H2 Zn finger	616..636	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000