DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31357 and Maea

DIOPT Version :9

Sequence 1:	NP_733044.1	Gene:	CG31357 / 326135	FlyBaseID:	FBgn0051357	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_067475.2	Gene:	Maea / 59003	MGIID:	1891748	Length:	396	Species:	Mus musculus

Alignment Length:	399	Identity:	191/399 - (47%)
Similarity:	266/399 - (66%)	Gaps:	24/399 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IKALEHATLKVPYEMLNKRFRSAQKIIDREVDQVINVSRQVEKALEAEEGPILAEVTKLVDNVAQ 68
            :|..|:.|||||||.||||||:|||.||||...|..|..::||.|.:  .|.:..|..|:|.|.:
Mouse    14 LKVQEYPTLKVPYETLNKRFRAAQKNIDRETSHVTMVVAELEKTLSS--CPAVDSVVSLLDGVVE 76

  Fly    69 KLQVLKRKAEESINDELSVTQICKRKLDHLKGITPPSSVTGDLWQGSVDQ------WKRIRLDRL 127
            ||.||||||.|||..|....::|||:::|||             :.|.||      |||.|:||:
Mouse    77 KLSVLKRKAVESIQAEDESAKLCKRRIEHLK-------------EHSSDQPAAASMWKRKRMDRM 128

  Fly   128 VIEHLLRMGYYETAEELAAKSDVRHLTNLDIFQTSREVEDDLASHSTTKCVLWCIDNKSKLRKIN 192
            ::|||||.|||.||.:||.:|.:..|.|:::|.|::|||:.|....|..|:.||.||||:|||:.
Mouse   129 MVEHLLRCGYYNTAVKLARQSGIEDLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMK 193

  Fly   193 STIEFSLRVQEFIELVRQNQRFEAVKHSRRYFPAYEKTQLNEICHVMALLAYPADAQAEHYRKYM 257
            |.:|||||:||||||||||:|.:||:|:|::|...|.:||:|:..||.:||:|.|.....|:..:
Mouse   194 SCLEFSLRIQEFIELVRQNKRLDAVRHARKHFSQAEGSQLDEVRQVMGMLAFPPDTHISPYKDLL 258

  Fly   258 DPQRWQKLVLDFRQENYRLFQLSSTSVFSAAVQAGLSALKTPHCYAQ--TCRNLNCPVCQEDLNR 320
            ||.||:.|:..||.:||||.||.::|||:..:||||||:|||.||.:  :.::.:||||...||:
Mouse   259 DPARWRMLIQQFRYDNYRLHQLGNSSVFTLTLQAGLSAIKTPQCYKEDGSSKSPDCPVCSRSLNK 323

  Fly   321 IALKLPYSHCVQSRLICRVTGLPLNEHNQPMMLPNGQIFGQMALPDITKDDGTVTCPVTNTKFSN 385
            :|..||.:||..|||:|:::|..:||:|.|||||||.::|..:|..|.:|| .|.||.|...|..
Mouse   324 LAQPLPMAHCANSRLVCKISGDVMNENNPPMMLPNGYVYGYNSLLSIRQDD-KVVCPRTKEVFHF 387

  Fly   386 PKVEKVFVM 394
            .:.|||::|
Mouse   388 SQAEKVYIM 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31357	NP_733044.1	LisH	119..150	CDD:128913	19/30 (63%)
		CLTH	158..300	CDD:287564	74/141 (52%)
		CTLH	158..215	CDD:128914	34/56 (61%)
		CRA	215..302	CDD:214806	41/86 (48%)
Maea	NP_067475.2	Extracellular and involved in cell to cell contact. /evidence=ECO:0000250\|UniProtKB:Q7L5Y9	1..124		56/124 (45%)
		LisH	120..153	CDD:128913	19/32 (59%)
		CLTH	160..301	CDD:402305	74/140 (53%)
		RING-Ubox_Emp	336..383	CDD:319573	24/47 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838061
Domainoid	1	1.000	164	1.000	Domainoid score	I3931
eggNOG	1	0.900	-	-		E1_KOG0396
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4298
Inparanoid	1	1.050	378	1.000	Inparanoid score	I2052
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54998
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004704
OrthoInspector	1	1.000	-	-		oto93603
orthoMCL	1	0.900	-	-		OOG6_103231
Panther	1	1.100	-	-	LDO	PTHR12170
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R462
SonicParanoid	1	1.000	-	-		X3306
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790