DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31357 and maea

DIOPT Version :9

Sequence 1:	NP_733044.1	Gene:	CG31357 / 326135	FlyBaseID:	FBgn0051357	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	XP_012815800.1	Gene:	maea / 493335	XenbaseID:	XB-GENE-483832	Length:	425	Species:	Xenopus tropicalis

Alignment Length:	428	Identity:	190/428 - (44%)
Similarity:	267/428 - (62%)	Gaps:	53/428 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IKALEHATLKVPYEMLNKRFRSAQKIIDREVDQVINVSRQVEKALEAEEGPILAEVTKLVDNVAQ 68
            :|..|:.|||||||.||||||:|||.||||...|..|..::||.|.:...  :..|..|:|.|.:
Frog    14 LKVQEYPTLKVPYETLNKRFRAAQKNIDRETSHVTMVVAELEKTLSSCSA--VDSVVSLLDGVVE 76

  Fly    69 KLQVLKR-----------------------------KAEESINDELSVTQICKRKLDHLKGITPP 104
            ||.||||                             ||.|||..|....::|||:::|||
Frog    77 KLSVLKRKAVIQPHSHIPSPSTMESKVPESITPQWNKAVESIQAEDESAKLCKRRIEHLK----- 136

  Fly   105 SSVTGDLWQGSVDQ------WKRIRLDRLVIEHLLRMGYYETAEELAAKSDVRHLTNLDIFQTSR 163
                    :.|.||      ||:.|:||:::|||||.|||.||.:||.:|.:..|.|:::|.|::
Frog   137 --------EHSNDQVAAINMWKKKRMDRMMVEHLLRCGYYNTAVKLARQSGIEDLVNIEMFLTAK 193

  Fly   164 EVEDDLASHSTTKCVLWCIDNKSKLRKINSTIEFSLRVQEFIELVRQNQRFEAVKHSRRYFPAYE 228
            |||:.|....|..|:.||.||||:|||:.|.:|||||:||||||:|||:|.:||:|:|::|...|
Frog   194 EVEESLERQETMTCLAWCHDNKSRLRKMKSCLEFSLRIQEFIELIRQNKRLDAVRHARKHFSQAE 258

  Fly   229 KTQLNEICHVMALLAYPADAQAEHYRKYMDPQRWQKLVLDFRQENYRLFQLSSTSVFSAAVQAGL 293
            .:||:|:..||.:||:|:|.....|:..:||.||:.|:..||.:||||.||.:.|||:..:||||
Frog   259 GSQLDEVRQVMGMLAFPSDTHISPYKDLLDPARWRMLIQQFRYDNYRLHQLGNNSVFTITLQAGL 323

  Fly   294 SALKTPHCYAQ--TCRNLNCPVCQEDLNRIALKLPYSHCVQSRLICRVTGLPLNEHNQPMMLPNG 356
            ||:|||.||.:  |.:|.:||||.:.||::|..||.:||..|||:|:::|..:||:|.|||||||
Frog   324 SAIKTPQCYKEDGTSKNPDCPVCSKSLNKLAQPLPMAHCANSRLVCKISGDVMNENNPPMMLPNG 388

  Fly   357 QIFGQMALPDITKDDGTVTCPVTNTKFSNPKVEKVFVM 394
            .::|..:|..|.:|| .|.||.|...|:..:.|||::|
Frog   389 YVYGYNSLLSIRQDD-KVVCPRTKEVFNFSQAEKVYIM 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31357	NP_733044.1	LisH	119..150	CDD:128913	18/30 (60%)
		CLTH	158..300	CDD:287564	73/141 (52%)
		CTLH	158..215	CDD:128914	33/56 (59%)
		CRA	215..302	CDD:214806	41/86 (48%)
maea	XP_012815800.1	LisH	149..182	CDD:128913	18/32 (56%)
		CLTH	189..330	CDD:371161	73/140 (52%)
		RING-Ubox_Emp	365..412	CDD:319573	24/47 (51%)
		U-box domain, a modified RING finger	369..410	CDD:319573	20/41 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	164	1.000	Domainoid score	I3907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4298
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2142
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1087488at2759
OrthoFinder	1	1.000	-	-		FOG0004704
OrthoInspector	1	1.000	-	-		oto103833
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R462
SonicParanoid	1	1.000	-	-		X3306
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.090