DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31357 and maea

DIOPT Version :9

Sequence 1:	NP_733044.1	Gene:	CG31357 / 326135	FlyBaseID:	FBgn0051357	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_955843.2	Gene:	maea / 321575	ZFINID:	ZDB-GENE-030131-294	Length:	396	Species:	Danio rerio

Alignment Length:	393	Identity:	189/393 - (48%)
Similarity:	267/393 - (67%)	Gaps:	12/393 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IKALEHATLKVPYEMLNKRFRSAQKIIDREVDQVINVSRQVEKALEAEEGPILAEVTKLVDNVAQ 68
            :|..|:.|||||||.||||||:|||.||||...|..|..::||.|.:  .|::..|..|:|.|.:
Zfish    14 LKVQEYPTLKVPYETLNKRFRAAQKNIDRETSHVTMVVAELEKTLSS--FPVVDTVVSLLDGVVE 76

  Fly    69 KLQVLKRKAEESINDELSVTQICKRKLDHLKGITPPSSVTGDLWQGSVDQWKRIRLDRLVIEHLL 133
            ||..|||||.|||..|....::|||:::|||..:...       ..||:.||:.|:||:::||||
Zfish    77 KLSALKRKAAESIQAEDESAKLCKRRIEHLKEHSSDQ-------PASVNVWKKKRMDRMMVEHLL 134

  Fly   134 RMGYYETAEELAAKSDVRHLTNLDIFQTSREVEDDLASHSTTKCVLWCIDNKSKLRKINSTIEFS 198
            |.|||.||.:||.:|.:..|.|:::|.|::|||:.|....|..|:.||.||||:|||:.|.:|||
Zfish   135 RCGYYNTAVKLARQSGIEDLVNIEMFLTAKEVEESLERQETATCLAWCHDNKSRLRKMKSCLEFS 199

  Fly   199 LRVQEFIELVRQNQRFEAVKHSRRYFPAYEKTQLNEICHVMALLAYPADAQAEHYRKYMDPQRWQ 263
            ||:||||||:|||:|.:||:|:|::|...|..||:|:..||.:||:|:|.....|:..:||.||:
Zfish   200 LRIQEFIELIRQNKRMDAVRHARKHFSQAEGGQLDEVRQVMGMLAFPSDTHISPYKDLLDPARWK 264

  Fly   264 KLVLDFRQENYRLFQLSSTSVFSAAVQAGLSALKTPHCYAQ--TCRNLNCPVCQEDLNRIALKLP 326
            .|:..||.:||||.||.:.|||:..:||||||:|||.||.:  |.:|.:||||.:.||::|..||
Zfish   265 MLIQQFRYDNYRLHQLGNNSVFTITLQAGLSAIKTPQCYKEDGTSKNPDCPVCSKSLNKLAQPLP 329

  Fly   327 YSHCVQSRLICRVTGLPLNEHNQPMMLPNGQIFGQMALPDITKDDGTVTCPVTNTKFSNPKVEKV 391
            .:||..|||:|:::|..:||:|.|||||||.::|..:|..|.:|| .|.||.|...|:..:.|||
Zfish   330 MAHCANSRLVCKISGEVMNENNPPMMLPNGYVYGYNSLLSIRQDD-KVICPRTKEVFNFSQAEKV 393

  Fly   392 FVM 394
            ::|
Zfish   394 YIM 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31357	NP_733044.1	LisH	119..150	CDD:128913	18/30 (60%)
		CLTH	158..300	CDD:287564	73/141 (52%)
		CTLH	158..215	CDD:128914	33/56 (59%)
		CRA	215..302	CDD:214806	41/86 (48%)
maea	NP_955843.2	LisH	120..153	CDD:128913	18/32 (56%)
		CTLH	159..216	CDD:128914	33/56 (59%)
		CLTH	160..301	CDD:287564	73/140 (52%)
		CRA	212..304	CDD:214806	44/91 (48%)
		zf-RING_UBOX	340..379	CDD:290181	18/39 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581865
Domainoid	1	1.000	163	1.000	Domainoid score	I3931
eggNOG	1	0.900	-	-		E1_KOG0396
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4298
Inparanoid	1	1.050	382	1.000	Inparanoid score	I2010
OMA	1	1.010	-	-		QHG54998
OrthoDB	1	1.010	-	-		D1087488at2759
OrthoFinder	1	1.000	-	-		FOG0004704
OrthoInspector	1	1.000	-	-		oto41774
orthoMCL	1	0.900	-	-		OOG6_103231
Panther	1	1.100	-	-	LDO	PTHR12170
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R462
SonicParanoid	1	1.000	-	-		X3306
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800