DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31357 and SPBC106.13

DIOPT Version :9

Sequence 1:	NP_733044.1	Gene:	CG31357 / 326135	FlyBaseID:	FBgn0051357	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_595162.1	Gene:	SPBC106.13 / 2540173	PomBaseID:	SPBC106.13	Length:	404	Species:	Schizosaccharomyces pombe

Alignment Length:	407	Identity:	109/407 - (26%)
Similarity:	197/407 - (48%)	Gaps:	32/407 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LEHATLKVPYEMLNKRFRSAQKIIDREVDQVINVSRQVEKALEAEEGPILAEVTKLVDNVAQKLQ 71
            ||...:.:.:|.|...|:...:.::.| ..|||   .....|.::|...:.|..:.:|::..::.
pombe    11 LEKPGILLSFEQLRINFKHILRHLEHE-SHVIN---STLTTLISQENASMDEKIEKIDSLLSRVS 71

  Fly    72 VLKRKAEESINDE-LSVTQICKRKL--DHLKGITPPSSVTGDLWQGSVDQWKRIRLDRLVIEHLL 133
            .:|:|.:...:.| |.:.|...|.|  :.|:||.       |:.......|.|:||:|||.::::
pombe    72 TVKKKMKHLHDCEALFIKQTKSRLLFMNRLQGIR-------DMESADFLDWSRVRLNRLVADYMM 129

  Fly   134 RMGYYETAEELAAKSDVRHLTNLDIFQTSREVEDDLASHSTTKCVLWCIDNKSKLRKINSTIEFS 198
            ..||:..|..|...|.:.:|.:|.|::..:.:.|.:......:.:.||.::::.|:|.|||:|..
pombe   130 ANGYHGAAALLCKDSQLENLVDLGIYKRYQLIHDSILQQELKEVLSWCSEHRAILKKNNSTLELE 194

  Fly   199 LRVQEFIELVRQNQRFEAVKHSRRYFPAYEKTQLNEICHVMALLAYPADAQAEHYRKYMDPQRWQ 263
            :|:|.||||::..:..:|:..::.:|..:.......:....||||:|.......|...:...||:
pombe   195 VRLQRFIELIKSKKLCQAIAFAKAHFGTWANEHPARLQLAAALLAFPEFTNGSPYSLLLSDDRWE 259

  Fly   264 KLVLDFRQENYRLFQLSSTSVFSAAVQAGLSALKTPHCY------------AQTCRNLNCPVCQE 316
            .|...|......:..:.|..:..|.:.||||:||||.||            :||.:  .||||..
pombe   260 YLASLFTSNFTAVHNIPSVPLLHALLAAGLSSLKTPLCYLDANDDNPLALQSQTVK--QCPVCTP 322

  Fly   317 DLNRIALKLPYSHCVQSRLICRVTGLPLNEHNQPMMLPNGQIFGQMALPDITKDDGT----VTCP 377
            .||.:...|||:|..||.::..:||..|:..|.|:..|||:::|..:|....:.:||    :..|
pombe   323 CLNDLGKALPYAHITQSAIVDSLTGEGLDSDNCPVAFPNGRVYGIQSLISWNEANGTREGFLRDP 387

  Fly   378 VTNTKFSNPKVEKVFVM 394
            .:..:|....:.||:|:
pombe   388 YSGKEFPFQLLRKVYVV 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31357	NP_733044.1	LisH	119..150	CDD:128913	12/30 (40%)
		CLTH	158..300	CDD:287564	37/141 (26%)
		CTLH	158..215	CDD:128914	16/56 (29%)
		CRA	215..302	CDD:214806	22/86 (26%)
SPBC106.13	NP_595162.1	LisH	119..144	CDD:285685	9/24 (38%)
		CLTH	154..296	CDD:287564	37/141 (26%)
		CTLH	154..211	CDD:128914	16/56 (29%)
		CRA	207..298	CDD:214806	22/90 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	74	1.000	Domainoid score	I2533
eggNOG	1	0.900	-	-		E1_KOG0396
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4298
Inparanoid	1	1.050	160	1.000	Inparanoid score	I1243
OMA	1	1.010	-	-		QHG54998
OrthoFinder	1	1.000	-	-		FOG0004704
OrthoInspector	1	1.000	-	-		oto101276
orthoMCL	1	0.900	-	-		OOG6_103231
Panther	1	1.100	-	-	LDO	PTHR12170
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R462
SonicParanoid	1	1.000	-	-		X3306
TreeFam	1	0.960	-	-
	14	13.860